FlyBase Allele Report: Dmel\Atpα[01453a]

General Information

Symbol

Dmel\Atpα^01453a

Species

D. melanogaster

Name

FlyBase ID

FBal0009413

Feature type

allele

Associated gene

Dmel\Atpα

Associated Insertion(s)

P{PZ}Atpα^01453a

Carried in Construct

Also Known As

l(3)01453

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Feng et al., 1997)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

Insertion of a P{PZ} element into the first intron, approximately 3.1kb upstream of the intron 1-exon 2 border. The P{PZ} element is inserted in reverse orientation compared to the Atpα gene.

(Feng et al., 1997)

Insertion components

P{PZ}Atpα^01453a

Product class / Tool use(s)

Encoded product / tool

Tagged with

nuclear protein localization tag

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

lethal | recessive

(Palladino et al., 2003, Spradling et al., 1999, Schwarz and Benzer, 1997)

lethal - all die during embryonic stage (with Atpα^DTS1R1)

(Palladino et al., 2003)

lethal - all die during embryonic stage (with Atpα^DTS1R2)

(Palladino et al., 2003)

lethal - all die during embryonic stage (with Atpα^DTS2)

(Palladino et al., 2003)

lethal - all die during embryonic stage (with Atpα^DTS2R1)

(Palladino et al., 2003)

lethal - all die during embryonic stage (with Atpα^DTS2R2)

(Palladino et al., 2003)

lethal - all die during embryonic stage (with Atpα^DTS2R3)

(Palladino et al., 2003)

lethal - all die during embryonic stage (with Atpα^H64)

(Palladino et al., 2003)

lethal - all die during embryonic stage | recessive

(Feng et al., 1997)

paralytic | heat sensitive (with Atpα^DTS1)

(Palladino et al., 2003)

partially lethal - majority die (with Atpα^DTS1)

(Palladino et al., 2003)

partially lethal - majority live (with Atpα²²⁰⁶)

(Palladino et al., 2003)

some die during embryonic stage (with Atpα^DTS1R1)

(Palladino et al., 2003)

some die during embryonic stage (with Atpα^DTS1R2)

(Palladino et al., 2003)

some die during embryonic stage (with Atpα^DTS2)

(Palladino et al., 2003)

some die during embryonic stage (with Atpα^DTS2R1)

(Palladino et al., 2003)

some die during embryonic stage (with Atpα^DTS2R2)

(Palladino et al., 2003)

some die during embryonic stage (with Atpα^DTS2R3)

(Palladino et al., 2003)

some die during embryonic stage (with Atpα^H64)

(Palladino et al., 2003)

some die during embryonic stage | recessive

(Feng et al., 1997)

Phenotype Manifest In

septate junction

(Genova and Fehon, 2003)

Detailed Description

Statement

Reference

In Atpα^01453a homozygous mutants the adherens junction remains intact, with the regular spacing of plasma membranes maintained. However, the septae normally located between these membranes are reduced in number or absent.

(Genova and Fehon, 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions