FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Atpα00462
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General Information
Symbol
Dmel\Atpα00462
Species
D. melanogaster
Name
FlyBase ID
FBal0043635
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Progenitor genotype
Associated Insertion(s)
Cytology
Description

Insertion of a P{PZ} element into the first intron, approximately 8kb downstream of the exon 1-intron 1 border. The P{PZ} element is inserted in the same orientation as the Atpα gene.

Allele components
Component
Use(s)
Inserted element
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

No homozygous adult flies are recovered at 18-27oC, however, at 29-30oC homozygous adults are obtained. These homozygous flies can then be maintained at 29oC or 27oC and have a comparable viability to the parent strain at these temperatures. Matings between first generation homozygotes generally fail to produce any adult progeny at 20oC, but after a few generations of growing at 27oC, mating between homozygotes generates a few viable offspring at 20oC. The temperature-sensitive period is between early embryogenesis and the third larval instar stage. Adult homozygotes reared at 29-30oC, and then maintained at 27oC show severe defects in movement and phototactic behaviour, and are bang sensitive. These flies show defects in negative geotactic behaviour, with the severity of the phenotype increasing as the temperature decreases. Homozygotes show increased tolerance to high temperature compared to wild-type.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

A. Spradling.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Atpα00462
l(3)0145300462
Name Synonyms
Secondary FlyBase IDs
    References (3)