FB2026_02 , released June 18, 2026
Gene Group: DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION REGULATED KINASES
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General Information
Name
DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION REGULATED KINASES
Species
D. melanogaster
Symbol
DYRK
FlyBase ID
FBgg0000219
Date last reviewed
2015-03-25
Number of members
5
Description
Description
The DYRK (Dual-specificity tyrosine phosphorylation-regulated kinase) family kinases phosphorylate serine/threonine on other proteins (trans-phosphorylation), but can also autophosphorylate on tyrosine. Autophosphorylation within the activation loop occurs while still attached to the ribosome. (Adapted from PMID:15960979).
Notes on Group
Source Material
The DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION REGULATED KINASES Gene Group has been compiled using the following publication(s): Sopko et al., 2014, Kinstrie et al., 2010, Manning et al., 2002, and Morrison et al., 2000 .
Key Gene Ontology (GO) terms
Molecular Function
protein serine/threonine/tyrosine kinase activity
Biological Process
protein phosphorylation
Cellular Component
Enzymatic activity
Enzyme name (EC)
dual-specificity kinase (2.7.12.1)
Related Gene Groups
Parent group(s)
CMGC KINASES
Members (5)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
DYRK
DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION REGULATED KINASES
Dual-specificity Y Regulated Kinases
Dual-specificity tyrosine phosphorylation kinases
MNB/DYRK subfamily
MNB
Secondary FlyBase ID(s)
References (5)