FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term protein serine/threonine/tyrosine kinase activity ID (Ontology) GO:0004712 (Gene Ontology)
Definition Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
Also Known As"dual-specificity kinase activity" ; "dual-specificity protein kinase"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 protein serine/threonine/tyrosine kinase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | protein serine/threonine/tyrosine kinase activity       --
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kinase activity_________________________________________
phosphotransferase activity, alcohol group as acceptor__|
catalytic activity, acting on a protein_________________|
                                                        protein kinase activity
                                                         |__protein serine/threonine/tyrosine kinase activity  11 rec.
                                                             |__MAP kinase kinase activity 5 rec.
                                                                 |__JUN kinase kinase activity 1 rec.
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Is a protein kinase activity
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Synonyms
  • "dual-specificity kinase activity" EXACT[ EC:2 ]
    "dual-specificity protein kinase" EXACT
    "protein threonine/tyrosine kinase activity" NARROW
Secondary IDs
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EC:2.7.12.1
Reactome:R-HSA-5672969 "Phosphorylation of RAF"
Reactome:R-HSA-5674373 "MAP2Ks phosphorylate MAPK at the Golgi membrane"
Reactome:R-HSA-6802910 "Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants"
Reactome:R-HSA-6802916 "RAF is phosphorylated downstream of moderate kinase activity BRAF mutants"
Reactome:R-HSA-6802918 "Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants"
Reactome:R-HSA-6802921 "Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants"
Reactome:R-HSA-6802922 "Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS"
Reactome:R-HSA-6802924 "RAF is phosphorylated downstream of oncogenic RAS"
Reactome:R-HSA-6802927 "BRAF and RAF fusion mutant dimers are phosphorylated"
Reactome:R-HSA-6802941 "RAF is paradoxically phosphorylated downstream of kinase-inactive RAF"
Reactome:R-HSA-9656212 "Phosphorylation of RAF1 mutants"