FlyBase Gene Report: Dmel\mats

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Gene: Dmel\mats

General Information

Symbol

Dmel\mats

Species

D. melanogaster

Name

mob as tumor suppressor

Annotation Symbol

CG13852

Feature Type

protein_coding_gene

FlyBase ID

FBgn0038965

Gene Model Status

Stock Availability

10 publicly available

Gene Summary

Coactivator of Warts (Wts) kinase in the Hippo/SWH (Sav/Wts/Hpo)signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki)oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Mats is essential for early development and is required for proper chromosomal segregation in developing embryos. (UniProt, Q95RA8)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Pathway
UniProtKB
Interactive Fly

Also Known As

Mob

Key Links

Genomic Location

Cytogenetic map

Sequence location

3R:22,421,161..22,423,302 [+]

Recombination map

3-74

RefSeq locus

NT_033777 REGION:22421161..22423302

Sequence

Get Decorated FASTA

Genomic Maps

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (14 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables protein binding

inferred from physical interaction with UniProtKB:Q9VA38

(Lai et al., 2005)

inferred from physical interaction with UniProtKB:Q9NBK5

(He et al., 2005)

enables protein kinase activator activity

inferred from genetic interaction with FLYBASE:wts; FB:FBgn0011739

(Vrabioiu and Struhl, 2015)

inferred from direct assay

(Wei et al., 2007, Lai et al., 2005)

enables protein kinase binding

inferred from physical interaction with FLYBASE:trc; FB:FBgn0003744

(He et al., 2005)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables protein kinase activator activity

inferred from biological aspect of ancestor with PANTHER:PTN000502949

(GO Reference Genome Project, 2011-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in apoptotic process

inferred from mutant phenotype

(Lai et al., 2005)

involved_in chromosome segregation

inferred from mutant phenotype

(Shimizu et al., 2008)

involved_in follicle cell of egg chamber development

inferred from mutant phenotype

(Jia et al., 2015)

involved_in hippo signaling

inferred from mutant phenotype

(Ho et al., 2010)

inferred from genetic interaction with FLYBASE:hpo; FB:FBgn0261456

(Wei et al., 2007, Lai et al., 2005)

involved_in negative regulation of cell population proliferation

inferred from mutant phenotype

(Lai et al., 2005)

inferred from mutant phenotype

(Ho et al., 2010)

involved_in signal transduction

inferred from mutant phenotype

(He et al., 2005)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in hippo signaling

inferred from biological aspect of ancestor with PANTHER:PTN000503077

(GO Reference Genome Project, 2011-)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

located_in centrosome

inferred from direct assay

(Shimizu et al., 2008)

located_in cytosol

inferred from direct assay

(Shimizu et al., 2008)

located_in nucleus

inferred from direct assay

(Shimizu et al., 2008)

located_in plasma membrane

inferred from direct assay

(Ho et al., 2010)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000502948

(GO Reference Genome Project, 2011-)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000502949

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Pathway (FlyBase)

HIPPO SIGNALING PATHWAY CORE COMPONENTS

Protein Family (UniProt)

Belongs to the MOB1/phocein family. (Q95RA8)

Protein Signatures (InterPro)

Summaries

Pathway (FlyBase)

HIPPO SIGNALING PATHWAY CORE COMPONENTS -: The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Activation of the Hippo pathway results in the down-regulation of cell proliferation and up-regulation of apoptosis, limiting tissue size. (Adapted from FBrf0224870).

Protein Function (UniProtKB)

Coactivator of Warts (Wts) kinase in the Hippo/SWH (Sav/Wts/Hpo)signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki)oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Mats is essential for early development and is required for proper chromosomal segregation in developing embryos.

(UniProt, Q95RA8)

Summary (Interactive Fly)

physically associates with cell cycle regulator Warts to stimulate its catalytic activity and associates with tissue polarity factor Tricornered to regulate denticle development - activated by Hippo kinase for growth inhibition in Drosophila

Interactive Fly

Gene Model and Products

Number of Transcripts

3

Number of Unique Polypeptides

1

Please see the JBrowse view of Dmel\mats for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q95RA8)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.48

Gene model reviewed during 5.55

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0084229

1260

219

FBtr0337044

1716

219

FBtr0345205

1096

219

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0083624

25.2

219

6.60

FBpp0307973

25.2

219

6.60

FBpp0311400

25.2

219

6.60

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

219 aa isoforms: mats-PA, mats-PB, mats-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts with and activates trc and wts.

(UniProt, Q95RA8)

Post Translational Modification

Phosphorylated by wts/mats kinase complex. Activated by phosphorylation by Hippo (Hpo) kinase which increases its affinity and its ability to activate Warts (Wts) kinase.

(UniProt, Q95RA8)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mats using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

mats_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.08

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | ubiquitous

(Fisher et al., 2012)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Yang et al., 2008)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic/larval anterior midgut

(Yang et al., 2008)

embryonic/larval salivary gland

(Ho et al., 2010)

third instar larval stage

wing disc | ubiquitous

(Shimizu et al., 2008)

eye disc | ubiquitous

(Shimizu et al., 2008)

leg disc | ubiquitous

(Shimizu et al., 2008)

• plasma membrane

(Ho et al., 2010)

(Ho et al., 2010)

Additional Descriptive Data

mats is expressed ubiquitously at a low level in third instar larval imaginal discs.

(Shimizu et al., 2008)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in centrosome

inferred from direct assay

(Shimizu et al., 2008)

located_in cytosol

inferred from direct assay

(Shimizu et al., 2008)

located_in nucleus

inferred from direct assay

(Shimizu et al., 2008)

located_in plasma membrane

inferred from direct assay

(Ho et al., 2010)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\mats in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\mats

View exonic expression by tissue for Dmel\mats

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0038965

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42634/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0038965

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0038965

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0038965

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG13852

Flygut - An atlas of the Drosophila adult midgut

FBgn0038965

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\mats

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 11 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 17 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of mats

Transgenic constructs containing regulatory region of mats

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

(Ryder, 2004.4.26)

Df(3R)mats^e325

(Lai et al., 2005)

Gene partially disrupted in

Df(3R)mats^e325

(Lai et al., 2005)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^Mef2.PR

mats^GD8136

lethal (with Df(3R)Exel6191)

mats^e03077

lethal (with mats^e235)

mats^e03077

lethal (with mats^e03077)

mats^e235

lethal - all die before end of second instar larval stage

mats^roo

lethal - all die before end of second instar larval stage (with mats^e235)

mats^roo

lethal - all die before end of second instar larval stage (with mats^roo)

mats^e235

lethal - all die before end of second instar larval stage | recessive

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

mats^GD8136

viable, with Scer\GAL4^ey.PH

mats^UAS.cLa

viable, with Scer\GAL4^pnr-MD237

mats^GD8136

viable, with Scer\GAL4^tin.CΔ4

mats^GD8136

viable (with mats^A33)

mats^e235

viable (with mats^e235)

mats^A33

Other Phenotypes

Allele

abnormal body color, with Scer\GAL4^pnr-MD237

mats^GD8136

abnormal body color | somatic clone

mats^e03077

abnormal immune response | adult stage (with mats^A33)

mats^e235

abnormal immune response | adult stage (with mats^e235)

mats^A33

abnormal mitotic cell cycle | somatic clone

mats^e235

abnormal neuroanatomy | embryonic stage

mats^e03077

abnormal neuroanatomy | somatic clone

mats^unspecified

increased cell number | larval stage | somatic clone

mats^roo

increased size | adult stage, with Scer\GAL4^en-e16E

mats^KK100140

increased size | adult stage, with Scer\GAL4^ptc.PU

mats^HMS00475

neoplasia | adult stage, with mats^2236.GFP

mats^roo

neoplasia | adult stage, with mats^roo

mats^2236.GFP

neoplasia | adult stage, with mats^roo/mats^e235

mats^2236.GFP

neoplasia | adult stage (with mats^e17)

mats^e235

neoplasia | adult stage (with mats^e235)

mats^e17

neoplasia | adult stage (with mats^e235), with mats^2236.GFP

mats^roo

neoplasia | adult stage (with mats^roo), with mats^2236.GFP

mats^e235

neoplasia | adult stage | dominant

neoplasia | somatic clone

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

mats^GD8136

some die during second instar larval stage

mats^roo

some die during second instar larval stage (with mats^e235)

mats^roo

some die during second instar larval stage (with mats^roo)

mats^e235

some die during second instar larval stage | recessive

visible, with Scer\GAL4^pnr-MD237

mats^GD8136

visible | adult stage, with Scer\GAL4^en-e16E

mats^KK100140

visible | adult stage, with Scer\GAL4^ptc.PU

mats^HMS00475

visible | somatic clone

mats^e03077

wild-type, with Scer\GAL4^ey.PH

mats^UAS.cLa

Phenotype manifest in

Allele

adult mushroom body | somatic clone

mats^unspecified

anepisternum (with mats^e17)

mats^e235

anepisternum (with mats^e235)

mats^e17

mats^e03077

mats^unspecified

larval RP2 motor neuron | embryonic stage

mats^e03077

mesonotum, with Scer\GAL4^pnr-MD237

mats^GD8136

posterior crossvein, with Scer\GAL4^en-e16E

mats^KK100140

postpronotum (with mats^e17)

mats^e235

postpronotum (with mats^e235)

mats^e17

trichogen cell, with Scer\GAL4^pnr-MD237

mats^GD8136

wing, with Scer\GAL4^en-e16E

mats^KK100140

wing, with Scer\GAL4^ptc.PU

mats^HMS00475

wing | somatic clone

mats^e03077

wing hair | somatic clone

mats^e03077

wing hair | somatic clone | increased number

mats^e03077

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (7)

14 of 14

Yes

Yes

13 of 14

No

Yes

5

6 of 14

No

No

6 of 14

No

No

6 of 14

No

No

3 of 14

No

No

1 of 14

No

No

1

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (7)

14 of 14

Yes

Yes

12 of 14

No

Yes

6 of 14

No

No

6 of 14

No

No

5 of 14

No

No

3 of 14

No

No

1 of 14

No

No

Mus musculus (laboratory mouse) (7)

14 of 14

Yes

Yes

13 of 14

No

Yes

6 of 14

No

No

6 of 14

No

No

5 of 14

No

No

3 of 14

No

No

1 of 14

No

No

Xenopus tropicalis (Western clawed frog) (8)

11 of 13

Yes

Yes

10 of 13

No

Yes

5 of 13

No

No

5 of 13

No

No

3 of 13

No

No

2 of 13

No

No

1 of 13

No

No

1 of 13

No

No

Danio rerio (Zebrafish) (9)

14 of 14

Yes

Yes

13 of 14

No

Yes

12 of 14

No

Yes

6 of 14

No

No

5 of 14

No

No

3 of 14

No

Yes

3 of 14

No

No

3 of 14

No

No

1 of 14

No

No

Caenorhabditis elegans (Nematode, roundworm) (4)

7 of 14

Yes

Yes

6 of 14

No

No

2 of 14

No

No

1 of 14

No

No

Anopheles gambiae (African malaria mosquito) (4)

Agam\AgaP_AGAP002066

12 of 12

Yes

Yes

Agam\AgaP_AGAP007872

6 of 12

No

No

Agam\AgaP_AGAP010841

3 of 12

No

No

Agam\AgaP_AGAP007306

1 of 12

No

No

Arabidopsis thaliana (thale-cress) (5)

13 of 13

Yes

Yes

13 of 13

Yes

Yes

8 of 13

No

Yes

4 of 13

No

Yes

1 of 13

No

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

12 of 13

Yes

Yes

3 of 13

No

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

11 of 12

Yes

Yes

3 of 12

No

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:mats. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (3)

10 of 13

4 of 13

3 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

MOB1B; MOB kinase activator 1B

14 of 14

MOB1A; MOB kinase activator 1A

13 of 14

MOB3A; MOB kinase activator 3A

6 of 14

MOB3B; MOB kinase activator 3B

6 of 14

MOB3C; MOB kinase activator 3C

6 of 14

MOB2; MOB kinase activator 2

3 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Dmel gene

Ortholog showing functional complementation

Supporting References

(Lai et al., 2005)

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-RNA

Physical Interaction

Assay

References

luminiscence technology, quantitative reverse transcription pcr

(Truscott et al., 2011)

protein-protein

Physical Interaction

Assay

References

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

pull down, western blot, enzymatic study, autoradiography

(Zheng et al., 2017, Zheng et al., 2015, Jin et al., 2012)

enzymatic study, western blot

(Zheng et al., 2015)

mats - l(1)G0289

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

(He et al., 2005)

anti tag coimmunoprecipitation, peptide massfingerprinting, anti tag western blot, enzymatic study, western blot, two hybrid, pull down

(Ding et al., 2021, Kwon et al., 2013, Yin et al., 2013, Ho et al., 2010, Wei et al., 2007, He et al., 2005, Lai et al., 2005)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Mok and Choi, 2022)

enhanceable

(Keder et al., 2015)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Lai et al., 2005)

suppressible

(Li et al., 2024)

enhanceable

(He et al., 2005)

suppressible

(He et al., 2005)

suppressible

(Lai et al., 2005)

enhanceable

(Lai et al., 2005)

External Data

Subunit Structure (UniProtKB)

Interacts with and activates trc and wts.

(UniProt, Q95RA8 )

Linkouts

BioGRID - A database of protein and genetic interactions.

67590

DroID - A comprehensive database of gene and protein interactions.

FBgn0038965

MIST (genetic) - An integrated Molecular Interaction Database

42634

MIST (protein-protein) - An integrated Molecular Interaction Database

42634

Pathways

Signaling Pathways (FlyBase)

HIPPO SIGNALING PATHWAY CORE COMPONENTS

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

3R

Recombination map

3-74

Cytogenetic map

Sequence location

3R:22,421,161..22,423,302 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

94A12-94A12

Limits computationally determined from genome sequence between P{PZ}l(3)rQ178^rQ178 and P{lacW}Dph5^L4910

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-74

(FlyBase, 2016)

3-77.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

32095

w^*; P{UAS-mats.L}3a P{UAS-mats.L}3b

29567

y¹ v¹; P{TRiP.JF03246}attP2

18115

w¹¹¹⁸; PBac{RB}mats^e03077/TM6B, Tb¹

34959

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00475}attP2

600524

w^*; sna^Sco/CyO; P{neoFRT}82B mats^roo/TM6B, Tb¹

39753

y^* w^*; P{lacW}mats^S113416/TM3, Sb¹ Ser¹

v108080

P{KK100140}VIE-260B

v17716

w¹¹¹⁸; P{GD8136}v17716

v318727

PBac{fTRG01023.sfGFP-TVPTBF}VK00002

v341744

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00864}attP40/CyO-GFP

Genomic Clones (2)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (21)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD47553

Other clones

DPiM_LD47553

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0038965

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0038965

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Area matching Drosophila EST AA201430.

(Davies, 2001.3.15)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG13852 anon-WO0118547.303

(FlyBase, 1996-)

Additional comments

Source for merge of CG13852 anon-WO0118547.303 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: CG13852 mats

(Lai et al., 2005)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (15)

Reported As

Symbol Synonym

CG13852

(Hosono et al., 2015, Ni et al., 2011.7.19, Schulte et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, He et al., 2005, Giot et al., 2003, Davies et al., 2001, O'Farrell, 2001.9.11, Robertson, 2001.7.7)

DMob1

(Domingues et al., 2005)

Dmob1

(He et al., 2005)

MATS

(Mirzoyan et al., 2019, Grifoni et al., 2013, Harvey and Hariharan, 2012)

Mats

(Gou et al., 2023, Kim et al., 2023, Cho and Jiang, 2021, Ding et al., 2021, Gogia et al., 2021, Chen et al., 2020, Cui et al., 2020, Gou et al., 2020, Sahu and Mondal, 2020, van Soldt and Cardoso, 2020, Gokhale and Pfleger, 2019, Bae and Luo, 2018, Enomoto et al., 2018, Fulford et al., 2018, Hergovich, 2017, Richardson and Portela, 2017, Tue et al., 2017, Zheng et al., 2017, Fallahi et al., 2016, Hergovich, 2016, Meng et al., 2016, Cao et al., 2015, Dong et al., 2015, Irvine and Harvey, 2015, Zheng et al., 2015, Sadeqzadeh et al., 2014, Andersen et al., 2013, Enderle and McNeill, 2013, Huang et al., 2013, Johnston, 2013, Kwon et al., 2013, Levayer and Moreno, 2013, Matsui and Lai, 2013, Rister et al., 2013, Yang and Hata, 2013, Yin et al., 2013, Yu and Guan, 2013, Fausti et al., 2012, Hergovich and Hemmings, 2012, Jin et al., 2012, Liu et al., 2012, Genevet and Tapon, 2011, Halder and Johnson, 2011, Laprise, 2011, Zhao et al., 2011, Ren et al., 2010, Hariharan, 2006, Polesello et al., 2006, Bateman and McNeill, 2005)

Mob

(van Soldt and Cardoso, 2020, Mirzoyan et al., 2019)

Mob1

(Schulte et al., 2010)

Mob1A/B

(van Soldt and Cardoso, 2020)

anon-WO0118547.303

dmob1

(Wainman et al., 2004)

mats

(He et al., 2025, Kroeger et al., 2024, Li et al., 2024, Sun et al., 2024, Zhang et al., 2023, Sang et al., 2021, Tokamov et al., 2021, Baker, 2020, Chang et al., 2019, Snigdha et al., 2019, Albert et al., 2018, Gene Disruption Project members, 2018-, Gou et al., 2018, Jia et al., 2018, Anderson et al., 2017, Baker, 2017, Kulaberoglu et al., 2017, Liu et al., 2016, Sarov et al., 2016, Jia et al., 2015, Keder et al., 2015, Ni et al., 2015, Sun et al., 2015, Vrabioiu and Struhl, 2015, Wang and Baker, 2015, Robbins et al., 2014, Kwon et al., 2013, Kwon et al., 2013, Lucas et al., 2013, Wehr et al., 2013, Zhang and Lai, 2013, Ye et al., 2012, Bao et al., 2011, Fernández et al., 2011, Jukam and Desplan, 2011, Rauskolb et al., 2011, Truscott et al., 2011, Zhang et al., 2011, Fang and Adler, 2010, Ho et al., 2010, Kong et al., 2010, Kong et al., 2010, Schulte et al., 2010, Dutta and Baehrecke, 2008, Oh and Irvine, 2008, Schuldiner et al., 2008, Shimizu et al., 2008, Sun et al., 2008, Yang et al., 2008, Fang and Adler, 2007, Menut et al., 2007, Polesello and Tapon, 2007, Tyler et al., 2007, Wei et al., 2007, Wei et al., 2007, Cho et al., 2006, He et al., 2005)

Name Synonyms

Mats

(Mohajan et al., 2021, Moon et al., 2018, Thompson and Sahai, 2015, Bao et al., 2011)

Mob as tumor suppresso

(Zhang and Lai, 2013)

Mob as tumor suppressor

(Kwon et al., 2013, Fausti et al., 2012, Halder and Johnson, 2011, Ho et al., 2010, Wei et al., 2007, Colombani et al., 2006)

Mob-as-tumor-supressor

(Sadeqzadeh et al., 2014)

mats

(Harvey et al., 2013, Xu and Bergmann, 2008)

mob as tumor suppressor

(Mummery-Widmer et al., 2009, Shimizu et al., 2008, Sun et al., 2008, Yang et al., 2008, Cho et al., 2006, Edgar, 2006, Lai et al., 2005)

Secondary FlyBase IDs

FBgn0062109

Datasets (1)

Study focus (1)

Experimental Role

Project

Project Type

Title

bait_protein

Hippo_Pathway_interaction_map

interactome

Interaction map generated by purification of Hippo pathway factors, with identification of copurifying proteins by mass spectrometry.

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 51 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42634

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q95RA8

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q95RA8

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

A0A0B4KGK3

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q95RA8

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0038965

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42634/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0038965

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0038965

FlyMine - An integrated database for Drosophila genomics

FBgn0038965

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG13852

MARRVEL_MODEL - MARRVEL (model organism gene)

42634

Linkouts

BioGRID - A database of protein and genetic interactions.

67590

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0038965

DroID - A comprehensive database of gene and protein interactions.

FBgn0038965

DRSC - Results frm RNAi screens

FBgn0038965

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

mats_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0038965

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0038965

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG13852

Flygut - An atlas of the Drosophila adult midgut

FBgn0038965

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC004387

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (genetic) - An integrated Molecular Interaction Database

42634

MIST (protein-protein) - An integrated Molecular Interaction Database

42634

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (168)