FB2026_03 , released September 17, 2026
CV Term Report
Help Close All Open All
General Information
Term hippo signaling ID (Ontology) GO:0035329 (Gene Ontology)
Definition An intracellular signaling cascade that starts with the activation of hippo (STK4/MST1 and STK3/MST2 in mammals and hpo kinase in Drosophila). Hippo then phosphorylates LATS1/2, which in turn phosphoylates the transcriptional co-activator YAP1 (yki in Drosophila), leading to its cytosolic retention and/or degradation.[ PubMed:17318211 PubMed:18328423 PubMed:36347846 ]
Also Known As"hippo signal transduction" ; "hippo signaling pathway"
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS

Choose a record type to view annotations for this term and its child terms. Direct annotations and full annotation statements below also provide HitList buttons.

    • Results list data from multiple species. Choose a record type above to open its HitList.
Direct annotations: records annotated with this exact term (child terms are NOT included)
Data ClassFieldDirect annotations
Genes (FBgn)GO_BIOLOGICAL_PROCESS
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 hippo signaling (all annotations which use CV term, excluding "NOT" statements)
     involved_in | hippo signaling       --
Spanning Tree (Parents/Children)
Only view relationship:
Vocabulary search 
  signal transduction
   |__intracellular signal transduction
       |__hippo signaling  100 rec.
           |__regulation of hippo signaling 93 rec.
               |__negative regulation of hippo signaling 51 rec.
               |__positive regulation of hippo signaling 43 rec.
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a intracellular signal transduction
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "hippo signal transduction" EXACT
    "hippo signaling cascade" RELATED
    "hippo signaling pathway" EXACT
    "hippo signalling cascade" RELATED
    "Salvador-Warts-Hippo signaling pathway" NARROW
    "SWH pathway" NARROW
Secondary IDs
hide External Crossreferences & Linkouts
Reactome:R-HSA-2028269 "Signaling by Hippo"