FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\matsroo
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General Information
Symbol
Dmel\matsroo
Species
D. melanogaster
Name
FlyBase ID
FBal0178932
Feature type
allele
Associated gene
Dmel\mats
Associated Insertion(s)
roo{}matsroo
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
transposable element activity
(Lai et al., 2005)
Progenitor genotype
Associated Insertion(s)
roo{}matsroo
Cytology
Description

The roo sequence is inserted behind codon 84 to cause a premature termination.

(Lai et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Occasional matsroo/+ mutant flies are observed to develop tumors.

      Some flies expressing mats2236.T:Avic\GFP in a homozygous matsroo mutant background exhibit small tumors.

      Some flies expressing mats2236.T:Avic\GFP in a matsroo/matse235 mutant background exhibit small tumors.

      (Yang et al., 2008)

      When matsroo mutant clones are made, large tumors can be induced in many organs, including the head, notum, eye wing, antenna and halteres. The tumor cells form unpatterned tissues with many folds on the surface, the mutant cells clearly overproliferating. Cell size is not significantly different from wild-type. When clones are made in the larval eye discs, photoreceptors and cone cells appear to be specified normally, however they fail to fully differentiate to generate ommatidia in adults.

      (Lai et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      matsroo allows recovery of Df(1)su(s)R194/+ clones in the adult eye in animals with mosaic eyes containing two genotypes of cells with respect to RpL36; cells which are Df(1)su(s)R194/+ and cells in which the haplo-insufficiency of Df(1)su(s)R194/+ for RpL36 has been rescued by RpL36+t4 (in a wild-type background the Df(1)su(s)R194/+ clones are eliminated by cell competition and are not seen in the adult eye in these animals). matsroo does not prevent loss of Df(1)su(s)R194/+ clones in the wing disc.

      (Tyler et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      matsroo is rescued by matsUAS.cLa/Scer\GAL4arm.PS

      (Lai et al., 2005)
      Partially rescued by

      matsroo is partially rescued by mats2236.GFP

      (Yang et al., 2008)

      matsroo/matse235 is partially rescued by mats2236.GFP

      (Yang et al., 2008)

      matsroo is partially rescued by matsUAS.cLa/Scer\GAL4αTub84B.PL

      (Lai et al., 2005)
      Not rescued by

      matsroo is not rescued by matsΔ5.GFP

      (Yang et al., 2008)

      matsroo is not rescued by matsΔ3.GFP

      (Yang et al., 2008)
      Comments

      matse17 fails to complement the tissue overgrowth seen in matsroo.

      matse17 complements the lethality associated with matsroo.

      Expression of mats2236.T:Avic\GFP partially rescues the second instar larval lethality seen in homozygous matsroo mutant flies. 60% of flies survive to the pupal stage and 25% reach the adult stage.

      Expression of mats2236.T:Avic\GFP partially rescues the second instar larval lethality seen in homozygous matsroo/matse235 mutant flies. Many flies survive to the pupal stage with some reaching the adult stage.

      matsΔ5.T:Avic\GFP is unable to rescue the second instar larval lethality seen in homozygous matsroo mutant flies.

      matsΔ3.T:Avic\GFP is unable to rescue the second instar larval lethality seen in homozygous matsroo mutant flies.

      (Yang et al., 2008)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      matsroo
      (Kulaberoglu et al., 2017, Yang et al., 2008, Tyler et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)