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Vasiliauskas, D., Mazzoni, E.O., Sprecher, S.G., Brodetskiy, K., Johnston, R.J., Lidder, P., Vogt, N., Celik, A., Desplan, C. (2011). Feedback from rhodopsin controls rhodopsin exclusion in Drosophila photoreceptors.  Nature 479(7371): 108--112.
FlyBase ID
FBrf0216554
Publication Type
Research paper
Abstract

Sensory systems with high discriminatory power use neurons that express only one of several alternative sensory receptor proteins. This exclusive receptor gene expression restricts the sensitivity spectrum of neurons and is coordinated with the choice of their synaptic targets. However, little is known about how it is maintained throughout the life of a neuron. Here we show that the green-light sensing receptor rhodopsin 6 (Rh6) acts to exclude an alternative blue-sensitive rhodopsin 5 (Rh5) from a subset of Drosophila R8 photoreceptor neurons. Loss of Rh6 leads to a gradual expansion of Rh5 expression into all R8 photoreceptors of the ageing adult retina. The Rh6 feedback signal results in repression of the rh5 promoter and can be mimicked by other Drosophila rhodopsins; it is partly dependent on activation of rhodopsin by light, and relies on G(αq) activity, but not on the subsequent steps of the phototransduction cascade. Our observations reveal a thus far unappreciated spectral plasticity of R8 photoreceptors, and identify rhodopsin feedback as an exclusion mechanism.

PubMed ID
PubMed Central ID
PMC3208777 (PMC) (EuropePMC)
Related Publication(s)
Personal communication to FlyBase

Location data for Rh3[1] and Rh4[1] mutations.
Vasiliauskas D. and Desplan C., 2013.10.03, Location data for Rh3[1] and Rh4[1] mutations. [FBrf0222868]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nature
    Title
    Nature
    Publication Year
    1869-
    ISBN/ISSN
    0028-0836
    Data From Reference