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FB2026_01
,
released March 12, 2026
trp-like, trp-l, DmTRPL
Please see the JBrowse view of Dmel\trpl for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.48
4.0 (northern blot)
1124 (aa); 128 (kD predicted)
Forms heteromultimers with Trpgamma and, to a lower extent, with trp. Interacts with Fkbp59 in vivo and is found in the inaD signaling complex.
Binding of calmodulin to binding site 1 is Ca(2+) dependent, whereas binding of calmodulin to site 2 is Ca(2+) independent.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\trpl using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Eye-enriched transcripts determined by ratio of expression level in wild-type heads. versus expression level in so heads.
JBrowse - Visual display of RNA-Seq signals
View Dmel\trpl in JBrowse2-61
2-59.9
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
New stable cell line derived from S2-unspecified : S2 cells carrying an inducible trpl-EGFP transgene (gift from B. Minke) were used.
Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days.
The biophysical properties of trpl channels expressed in a stably transfected cell line are compared to those of trp. Results show that, for a wide range of properties, the native and expressed channels are functionally equivalent lending strong support to the proposal that channels encoded by trpl can completely account for the component of the light-sensitive conductance remaining in the trp mutant.
trpl expression is associated with the appearance of an outwardly rectifying, Ca2+ permeable, nonselective cation current that is constitutively active under nonstimulating conditions, giving rise to large increases in basal Ca2+.
trpl activity is masked by functional trp channels and together trp and trpl are essential components of the light-activated conductance. trp and trpl need not form heteromeric channels because trpl mutants only contain trp protein and trp mutants only have trpl protein. Since trp and trpl mutants respond to light activation then each channel on its own must be capable of sensing the intracellular messenger that gates the light activated conductance. Activation of one does not require prior activation of the other.
The C-terminal domain of the trpl protein contains two calmodulin-binding sites.
trpl expressed in Sf9 cells can be activated by hormonal factors after coinjection with recombinant viruses coding for various heptahelical, G-protein-coupled receptors.
Activity of recombinant trpl in Sf9 cells is studied.
trpl expression in Sf9 cells is associated with appearance of Ca2+ permeable, non-selective cation channels.
The calmodulin-binding and ankyrin-repeats have been investigated in vitro using fusion proteins.
A trpl cDNA has been cloned and sequenced.
Source for merge of: trpl CG18345
Source for merge of trpl CG18345 was sequence comparison ( date:001104 ).
