FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
trpl
FlyBase ID
FBig0000099154
Interaction Network
Interactions Browser links
trpl network
Reported Interactions
FBrf0097895-11.PD.A
Reference
Xu et al., 1997
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
trpl 

TRPL

bait

GST tag

trpl 

TRPL

prey

[35]S label

trpl 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
trpl 
N-terminal interaction domain residues 1-338
sufficient binding region
aa 1-338

coordinates relative to trpl-PA

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; bait produced as a recombinant fusion protein in bacterial system; prey produced and labeled by in vitro translation.

(Xu et al., 1997)
FBrf0097895-5.Y2H
Reference
Xu et al., 1997
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
trpl 

TRPL

bait

fused to GAL4 DNA-binding domain

trpl 

TRP

prey

fused to GAL4 activation domain

trpl 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
trpl 
N-terminal interaction domain residues 1-338
sufficient binding region
aa 1-338

coordinates relative to trpl-PA

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was yeast cell line; bait produced as transgenic fusion protein; prey produced as transgenic fusion protein (prey was previously cloned reagent).

(Xu et al., 1997)

Two-hybrid system: yeast GAL4-BD/VP16-AD

(Xu et al., 1997)
FBrf0222115-2.coIP.WB
Reference
Katz et al., 2013
Description
physical association
Assay
Collection
Source/Stage
adult head / adult stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
trpl 

TRPL

bait

GFP tag

trpl 

TRPL

prey
trpl 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
trpl 
C-terminal region
sufficient binding region
aa 681-1124
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

trpl forms homomultimers. trpl does not interact with trp.

(Katz et al., 2013)

Transgenic trpl expressed in photoreceptor cells. Anti-GFP antibody used for immunoprecipitation.

(Katz et al., 2013)

Source was adult heads of transgenic fly line; bait produced from tagged transgenic construct; prey produced from endogenous gene.

(Katz et al., 2013)

In trp::trpl chimeric proteins, a trpl derived C-terminal intracellular region is sufficient for interaction with endogenous trpl.

(Katz et al., 2013)
FBrf0243518-1.coIP.WB
Reference
Schopf et al., 2019
Description
physical association
Assay
Collection
Source/Stage
head / adult stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
trpl 

TRPL

bait

SNAP tag

trpl 

TRPL

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Co-immunoprecipitation of tagged and endogenous trpl was taken as evidence of homo-oligomerization.

(Schopf et al., 2019)

Source was adult heads of transgenic fly line; bait produced from tagged transgenic construct; prey produced from endogenous gene.

(Schopf et al., 2019)
External Crossreferences and Linkouts ( 0 )
References (3)