FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Trpγ
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General Information
Symbol
Dmel\Trpγ
Species
D. melanogaster
Name
Transient receptor potential cation channel γ
Annotation Symbol
CG5996
Feature Type
protein_coding_gene
FlyBase ID
FBgn0032593
Gene Model Status
Current
Stock Availability
16 publicly available
Gene Summary
A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction (By similarity). Forms a regulated cation channel when heteromultimerized with trpl. (UniProt, Q9VJJ7)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

trp-γ

Key Links
Genomic Location
Cytogenetic map
36A9-36A10
Sequence location
Recombination map
2-52
RefSeq locus
NT_033779 REGION:16663454..16676701
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (23 terms)
Molecular Function (7 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
enables mechanosensitive monoatomic ion channel activity
inferred from direct assay
(Akitake et al., 2015)
enables monoatomic cation channel activity
inferred from direct assay
(Jors et al., 2006, Xu et al., 2000)
enables protein binding
inferred from physical interaction with UniProtKB:P19334
(Xu et al., 2000)
inferred from physical interaction with UniProtKB:P48994
(Xu et al., 2000)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables calcium channel activity
inferred from electronic annotation with InterPro:IPR002153
(InterPro Project Members, 2004-)
inferred from sequence or structural similarity with UniProtKB:P19334
(Xu et al., 2000)
enables inositol 1,4,5 trisphosphate binding
inferred from biological aspect of ancestor with PANTHER:PTN000012230
(GO Reference Genome Project, 2011-)
enables monoatomic ion channel activity
inferred from electronic annotation with InterPro:IPR005821
(InterPro Project Members, 2004-)
enables store-operated calcium channel activity
inferred from biological aspect of ancestor with PANTHER:PTN000012230
(GO Reference Genome Project, 2011-)
Biological Process (10 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in adult walking behavior
inferred from mutant phenotype
(Akitake et al., 2015)
involved_in monoatomic cation transport
inferred from direct assay
(Xu et al., 2000)
involved_in neuromuscular process controlling posture
inferred from mutant phenotype
(Akitake et al., 2015)
Terms Based on Predictions or Assertions (7 terms)
CV Term
Evidence
References
involved_in calcium ion transmembrane transport
inferred from electronic annotation with InterPro:IPR002153
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000012230
(GO Reference Genome Project, 2011-)
involved_in calcium ion transport
inferred from sequence or structural similarity with UniProtKB:P19334
(Xu et al., 2000)
involved_in detection of light stimulus involved in visual perception
inferred from sequence or structural similarity with UniProtKB:P19334
(Xu et al., 2000)
involved_in monoatomic ion transport
inferred from electronic annotation with InterPro:IPR005821
(InterPro Project Members, 2004-)
involved_in regulation of cytosolic calcium ion concentration
inferred from biological aspect of ancestor with PANTHER:PTN000012230
(GO Reference Genome Project, 2011-)
involved_in response to light stimulus
traceable author statement
(Voets and Nilius, 2003)
inferred from sequence or structural similarity with UniProtKB:P19334
(Xu et al., 2000)
involved_in transmembrane transport
inferred from electronic annotation with InterPro:IPR005821
(InterPro Project Members, 2004-)
Cellular Component (6 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
part_of cation channel complex
inferred from physical interaction with FLYBASE:trpl; FB:FBgn0005614
(Xu et al., 2000)
located_in neuronal cell body
inferred from direct assay
(Akitake et al., 2015)
located_in proximal dendrite
inferred from direct assay
(Akitake et al., 2015)
located_in rhabdomere
inferred from direct assay
(Xu et al., 2000)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
part_of cation channel complex
inferred from biological aspect of ancestor with PANTHER:PTN000012230
(GO Reference Genome Project, 2011-)
located_in membrane
inferred from electronic annotation with InterPro:IPR002153, InterPro:IPR005821
(InterPro Project Members, 2004-)
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000012230
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. (Q9VJJ7)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
TRANSIENT RECEPTOR POTENTIAL ION CHANNELS -
The Transient Receptor Potential (TRP) channel family are cation channels conserved from invertebrates to humans. TRP channels respond to diverse stimuli and are involved in a number of environmental sensory pathways. (Adapted from FBrf0220930 and FBrf0225477).
MECHANOSENSITIVE TRANSIENT RECEPTOR POTENTIAL ION CHANNELS -
The Transient Receptor Potential (TRP) ion channels are cation channels. Some members of the TRP family have been shown to be gated by mechanical stimulation (Adapted from FBrf0248531.)
Protein Function (UniProtKB)
A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction (By similarity). Forms a regulated cation channel when heteromultimerized with trpl.
(UniProt, Q9VJJ7)
Summary (Interactive Fly)

Ca++ channel protein activated by polyunsaturated fatty acids generated in a phospholipase C- and phospholipase A2-dependent manner - motor coordination - olfactory sensitivity - Malpighian tubule fluid transport - photoresponse

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Trpγ for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VJJ7)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.47

Low-frequency RNA-Seq exon junction(s) not annotated.

Unconventional translation start (CUG) postulated; FBrf0218597 (FlyBase analysis); additional N-terminal aa sequence conserved in Drosophila species.

Gene model reviewed during 5.56

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Trpγ-RA
FBtr0080945
NM_135958
4232
1128
Trpγ-RB
FBtr0080946
NM_165169
4189
1128
Trpγ-RD
FBtr0335144
NM_001144358
5274
1188
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Trpγ-PA
FBpp0080498
127.1
1128
8.01
Q9VJJ7
NP_609802
AAF53548
Trpγ-PB
FBpp0080499
127.1
1128
8.01
Q9VJJ7
NP_723983
AAN10950
Trpγ-PD
FBpp0307143
133.5
1188
8.57
B7YZW4
NP_001137830
ACL83036
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1128 aa isoforms: Trpγ-PA, Trpγ-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts preferentially with trpl and interacts to a lower extent with trp.

(UniProt, Q9VJJ7)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Trpγ using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.26

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
scolopidial dendrite | subset of femoral chordotonal organ
(Akitake et al., 2015)
mechanosensory neuron of femoral chordotonal organ
(Akitake et al., 2015)
mechanosensory neuron of femoral chordotonal organ
(Akitake et al., 2015)
femoral chordotonal organ scolopale cell
(Akitake et al., 2015)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood | male -- day 7 of adulthood | male
spermatozoon
(Wasbrough et al., 2010)
Additional Descriptive Data

Trpγ-protein is expressed in scolopidial neurons where it labels cell bodies and proximal dendrites including the scolopidial cilium. Labeling is also detected in scolopale cells.

(Akitake et al., 2015)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of cation channel complex
inferred from physical interaction with FLYBASE:trpl; FB:FBgn0005614
(Xu et al., 2000)
located_in neuronal cell body
inferred from direct assay
(Akitake et al., 2015)
located_in proximal dendrite
inferred from direct assay
(Akitake et al., 2015)
located_in rhabdomere
inferred from direct assay
(Xu et al., 2000)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Trpγ in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Trpγ
Transgenic constructs containing regulatory region of Trpγ
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(2L)Exel7066
(Ryder, 2004.4.26)
Inferred from location ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Dcr-2UAS.cDa, Scer\GAL4e22c, Scer\GAL4sqh.PW
partially lethal, with Scer\GAL4tin.CΔ4
partially lethal - majority die, with Scer\GAL4pnr-MD237
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4e22c, Scer\GAL4sqh.PW
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal locomotor behavior | adult stage
abnormal neurophysiology | recessive, with Scer\GAL4Gr63a.PF
abnormal smell perception, with Scer\GAL4Gr63a.PF
short lived, with Scer\GAL4Ugt36A1.PK
some die during pupal stage, with Scer\GAL4pnr-MD237
uncoordinated | adult stage
uncoordinated | adult stage, with Scer\GAL4elav.PU
uncoordinated | adult stage, with Scer\GAL4iav.PU
uncoordinated | adult stage, with Scer\GAL4nan.PK
uncoordinated | adult stage, with Scer\GAL4nompA.cK
uncoordinated | adult stage, with Scer\GAL4Trpγ-G4, TrpγG4
uncoordinated | adult stage, with Scer\GAL4Trpγ-G4, TrpγKK107656
uncoordinated | adult stage (with Df(2L)ED1109)
uncoordinated | adult stage (with Trpγ1)
uncoordinated | adult stage (with TrpγG4)
Phenotype manifest in
Allele
adult pericardial cell, with Scer\GAL4Ugt36A1.PK
scolopale cell
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (14)
Hsap\TRPC4
13 of 14
Yes
Yes
Hsap\TRPC5
12 of 14
No
Yes
Hsap\TRPC1
7 of 14
No
Yes
Hsap\TRPC3
3 of 14
No
Yes
Hsap\TRPC6
3 of 14
No
Yes
Hsap\TRPC7
3 of 14
No
Yes
Hsap\PKD2L1
1 of 14
No
No
1  
Hsap\TRPM1
1 of 14
No
No
3  
Hsap\TRPM2
1 of 14
No
No
Hsap\TRPM3
1 of 14
No
No
Hsap\TRPM5
1 of 14
No
No
Hsap\TRPM6
1 of 14
No
No
3  
Hsap\TRPM7
1 of 14
No
No
2  
Hsap\TRPM8
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (17)
Rnor\Trpc4
13 of 14
Yes
Yes
Rnor\Trpc5
12 of 14
No
Yes
Rnor\Trpc1
6 of 14
No
Yes
Rnor\Trpc3
3 of 14
No
Yes
Rnor\Trpc6
3 of 14
No
Yes
Rnor\Trpc7
3 of 14
No
Yes
Rnor\Trpc2
2 of 14
No
Yes
Rnor\Xndc1
2 of 14
No
Yes
Rnor\Pkd2l1
1 of 14
No
No
Rnor\Trpm1
1 of 14
No
No
Rnor\Trpm2
1 of 14
No
No
Rnor\Trpm3
1 of 14
No
No
Rnor\Trpm5
1 of 14
No
No
Rnor\Trpm6
1 of 14
No
No
Rnor\Trpm7
1 of 14
No
No
Rnor\Trpm8
1 of 14
No
No
Rnor\Trpv1
1 of 14
No
No
Mus musculus (laboratory mouse) (16)
Mmus\Trpc4
12 of 14
Yes
Yes
Mmus\Trpc5
12 of 14
Yes
Yes
Mmus\Trpc1
7 of 14
No
Yes
Mmus\Trpc2
3 of 14
No
Yes
Mmus\Trpc3
3 of 14
No
Yes
Mmus\Trpc6
3 of 14
No
Yes
Mmus\Trpc7
3 of 14
No
Yes
Mmus\Pkd2l1
1 of 14
No
No
Mmus\Trpm1
1 of 14
No
No
Mmus\Trpm2
1 of 14
No
No
Mmus\Trpm3
1 of 14
No
No
Mmus\Trpm5
1 of 14
No
No
Mmus\Trpm6
1 of 14
No
No
Mmus\Trpm7
1 of 14
No
No
Mmus\Trpm8
1 of 14
No
No
Mmus\Xntrpc
1 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (16)
Xtro\trpc4
10 of 13
Yes
Yes
Xtro\trpc5
7 of 13
No
Yes
Xtro\trpc1
4 of 13
No
Yes
Xtro\reep6
3 of 13
No
No
Xtro\pitpnc1l
2 of 13
No
No
Xtro\ankrd10
1 of 13
No
Yes
Xtro\coa7
1 of 13
No
No
Xtro\ing1
1 of 13
No
No
Xtro\nopchap1
1 of 13
No
Yes
Xtro\slc12a3
1 of 13
No
No
Xtro\trpc2
1 of 13
No
Yes
Xtro\trpm3
1 of 13
No
No
Xtro\trpm6
1 of 13
No
No
Xtro\trpm8b
1 of 13
No
No
Xtro\trpm8
1 of 13
No
No
Xtro\XB5892783
1 of 13
No
No
Danio rerio (Zebrafish) (24)
Drer\trpc4a
12 of 14
Yes
Yes
Drer\trpc4b
11 of 14
No
Yes
Drer\trpc5a
11 of 14
No
Yes
Drer\trpc1
6 of 14
No
Yes
Drer\trpc5b
6 of 14
No
Yes
Drer\trpc2b
3 of 14
No
Yes
Drer\trpc6a
3 of 14
No
Yes
Drer\trpc2a
2 of 14
No
Yes
Drer\trpc3
2 of 14
No
Yes
Drer\trpc6b
2 of 14
No
Yes
Drer\trpc7a
2 of 14
No
Yes
Drer\trpc7b
2 of 14
No
Yes
Drer\LOC103910003
1 of 14
No
Yes
Drer\pkd2l1
1 of 14
No
No
Drer\trpm1a
1 of 14
No
No
Drer\trpm1b
1 of 14
No
No
Drer\trpm2
1 of 14
No
No
Drer\trpm3
1 of 14
No
No
Drer\trpm4a
1 of 14
No
No
Drer\trpm4b3
1 of 14
No
No
Drer\trpm4b.2
1 of 14
No
No
Drer\trpm6
1 of 14
No
No
Drer\trpn1
1 of 14
No
No
Drer\zgc:110224
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\trp-2
13 of 14
Yes
Yes
Cele\trp-1
3 of 14
No
Yes
Cele\spe-41
2 of 14
No
Yes
Cele\trp-4
2 of 14
No
No
Cele\trpa-1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (5)
Agam\AgaP_AGAP008435
12 of 12
Yes
Yes
Agam\AgaP_AGAP000348
5 of 12
No
No
Agam\AgaP_AGAP010630
5 of 12
No
No
Agam\AgaP_AGAP006825
1 of 12
No
No
Agam\AgaP_AGAP008559
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\YVC1
1 of 13
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Trpγ. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (4)
trpl
11 of 13
trp
11 of 13
nompC
2 of 13
Trpm
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 3 )
Potential Models Based on Orthology ( 2 )
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
TRPC4; transient receptor potential cation channel subfamily C member 4
13 of 14
603651
      TRPC5; transient receptor potential cation channel subfamily C member 5
      12 of 14
      300334
          TRPC1; transient receptor potential cation channel subfamily C member 1
          7 of 14
          602343
              TRPC3; transient receptor potential cation channel subfamily C member 3
              3 of 14
              602345
              TRPC6; transient receptor potential cation channel subfamily C member 6
              3 of 14
              603652
              TRPC7; transient receptor potential cation channel subfamily C member 7
              3 of 14
                  Functional Complementation Data
                  Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                  Interactions
                  Summary of Physical Interactions
                  Interaction Browsers
                  Summary of Genetic Interactions
                  Interaction Browsers
                  View in FlyBase Interactions Browser   View in MIST tool (external link)
                  Please look at the allele data for full details of the genetic interactions
                  Starting gene(s)
                  Interaction type
                  Interacting gene(s)
                  Reference
                  Trpγ
                  suppressible
                  Calx
                  (Akitake et al., 2015)
                  Starting gene(s)
                  Interaction type
                  Interacting gene(s)
                  Reference
                  Calx
                  suppressible
                  Trpγ
                  (Akitake et al., 2015)
                  External Data
                  Subunit Structure (UniProtKB)
                  Interacts preferentially with trpl and interacts to a lower extent with trp.
                  (UniProt, Q9VJJ7 )
                  Linkouts
                  DroID - A comprehensive database of gene and protein interactions.
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Pathways
                  Signaling Pathways (FlyBase)
                  Metabolic Pathways
                  FlyBase
                  External Links
                  External Data
                  Linkouts
                  KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                  Class of Gene
                  Genomic Location and Detailed Mapping Data
                  Chromosome (arm)
                  2L
                  Recombination map
                  2-52
                  Cytogenetic map
                  36A9-36A10
                  Sequence location
                  FlyBase Computed Cytological Location
                  Cytogenetic map
                  Evidence for location
                  36A9-36A10
                  Limits computationally determined from genome sequence between P{PZ}dacP and P{EP}grpEP921&P{lacW}l(2)k13905k13905
                  Experimentally Determined Cytological Location
                  Cytogenetic map
                  Notes
                  References
                  Experimentally Determined Recombination Data
                  Location

                  2-52

                  (FlyBase, 2016)

                  2-50.7

                  (Comeron et al., 2012)
                  Left of (cM)
                  Right of (cM)
                  Notes
                  Stocks and Reagents
                  Stocks (16)
                  Genomic Clones (24)
                  cDNA Clones (2)
                   

                  Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                  cDNA clones, fully sequenced
                  BDGP DGC clones
                    Other clones
                      Drosophila Genomics Resource Center cDNA clones

                      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                      cDNA Clones, End Sequenced (ESTs)
                      BDGP DGC clones
                        Other clones
                          RNAi and Array Information
                          Linkouts
                          DRSC - Results frm RNAi screens
                          Antibody Information
                          Laboratory Generated Antibodies
                           

                          polyclonal

                          (Akitake et al., 2015)
                          Commercially Available Antibodies
                           
                          Cell Line Information
                          Publicly Available Cell Lines
                           
                            Other Stable Cell Lines
                             
                              Other Comments

                              Trpγ is required for fine motor control.

                              (Akitake et al., 2015)

                              trpγ forms a receptor-activated outwardly rectifying cation channel which is activated by various polyunsaturated fatty acids generated in a phospholipase C- and phospholipase A2-dependent manner.

                              (Jors et al., 2006)

                              trpγ forms a regulated cation channel with trpl.

                              (Xu et al., 2000)

                              trpγ-trpl heteromultimers contribute to the photoresponse.

                              (Xu et al., 2000)
                              Relationship to Other Genes
                              Source for database merge of
                              Additional comments

                              Source for identity of trpγ CG5996 was sequence comparison ( date:000721 ).

                              (FlyBase, 1996-)
                              Nomenclature History
                              Source for database identify of

                              Source for identity of: trpγ CG5996

                              (FlyBase, 1996-)

                              Source for identity of: Trpγ trpγ

                              (FlyBase, 2009-)
                              Nomenclature comments
                              Etymology
                              Synonyms and Secondary IDs (15)
                              Reported As
                              Symbol Synonym
                              CG5996
                              (National Institute of Genetics Fly Stocks, 2022-, Chatterjee et al., 2014, Kanamori et al., 2013, Tsubouchi et al., 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Ni et al., 2009, Ni et al., 2008, Hollien and Weissman, 2006)
                              DmTRPgamma
                              (Matsuura et al., 2009)
                              TRPgamma
                              (Riehle et al., 2018, Ni et al., 2009, Delmas et al., 2004)
                              TRPγ
                              (Montell, 2021, Su et al., 2018, Venkatachalam et al., 2014, Fowler and Montell, 2013, Jors et al., 2006, Montell, 2005, Zelhof et al., 2003, Xu et al., 2000, Montell, 1999)
                              Trp-gamma
                              (Zhang et al., 2013)
                              Trp-γ
                              (Aggarwal et al., 2019)
                              Trpgamma
                              (National Institute of Genetics Fly Stocks, 2022-, Yan et al., 2018, Fu et al., 2017, Menuz et al., 2014, Shieh and Bonini, 2011)
                              Trpγ
                              (Bajar et al., 2022, Liu et al., 2022, Hehlert et al., 2021, Moon et al., 2021, Fujisawa et al., 2020)
                              dTRPg
                              (Voets and Nilius, 2003)
                              dTRPγ
                              (Wicher et al., 2006)
                              trp-gamma
                              (Roos et al., 2005)
                              trp-γ
                              (Hardie, 2001, Hardie and Raghu, 2001)
                              trpgamma
                              (Wasbrough et al., 2010, Hollien and Weissman, 2006)
                              trpγ
                              (Nath et al., 2025, Sang and Lee, 2024, Palacios-Muñoz et al., 2022, Tian et al., 2022, Jacobs and Sehgal, 2020, Ma and Freeman, 2020, Huang et al., 2019, Rimal and Lee, 2019, Zhang et al., 2016, Akitake et al., 2015, Wong et al., 2014, Kanamori et al., 2013, Zhang et al., 2013, Tsubouchi et al., 2012, Kain et al., 2010, Kim et al., 2010, Kwon et al., 2010, Kwon et al., 2010, Kwon et al., 2008, Montell, 2005, Nelson et al., 2005)
                              Name Synonyms
                              Transient receptor potential cation channel γ
                              Trpgamma
                              (Guo et al., 2020)
                              Trpγ
                              (Nakayama et al., 2014)
                              trpgamma
                              (Georlette et al., 2007)
                              trpγ
                              (Kwon et al., 2008)
                              Secondary FlyBase IDs
                                Datasets (0)
                                Study focus (0)
                                Experimental Role
                                Project
                                Project Type
                                Title
                                Study result (0)
                                Result
                                Result Type
                                Title
                                External Crossreferences and Linkouts ( 45 )
                                Sequence Crossreferences
                                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                Other crossreferences
                                AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                FlyMine - An integrated database for Drosophila genomics
                                InterPro - A database of protein families, domains and functional sites
                                KEGG Genes - Molecular building blocks of life in the genomic space.
                                MARRVEL_MODEL - MARRVEL (model organism gene)
                                Linkouts
                                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                DroID - A comprehensive database of gene and protein interactions.
                                DRSC - Results frm RNAi screens
                                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                Flygut - An atlas of the Drosophila adult midgut
                                FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                                KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                MIST (protein-protein) - An integrated Molecular Interaction Database
                                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                                References (92)