FlyBase Allele Report: Dmel\Trpγ[KK107656]

General Information

Symbol

Dmel\Trpγ^KK107656

Species

D. melanogaster

Name

FlyBase ID

FBal0235075

Feature type

allele

Associated gene

Dmel\Trpγ

Associated Insertion(s)

Carried in Construct

P{KK107656}

Also Known As

UAS-trpγRNAi, Trpγ-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK107656}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK107656

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of autism spectrum disorder

CEA

(Palacios-Muñoz et al., 2022)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

(Tsubouchi et al., 2012)

uncoordinated | adult stage, with Scer\GAL4^elav.PU

(Akitake et al., 2015)

uncoordinated | adult stage, with Scer\GAL4^iav.PU

(Akitake et al., 2015)

uncoordinated | adult stage, with Scer\GAL4^nan.PK

(Akitake et al., 2015)

uncoordinated | adult stage, with Scer\GAL4^nompA.cK

(Akitake et al., 2015)

uncoordinated | adult stage, with Scer\GAL4^Trpγ-G4, Trpγ^G4

(Akitake et al., 2015)

Phenotype Manifest In

Detailed Description

Statement

Reference

Trpγ^G4/+ flies expressing Trpγ^KK107656 under the control of Scer\GAL4^Trpγ-G4 have a reduced ability to successfully traverse large gaps of 3.5mm compared to Trpγ^G4/+ controls.

Flies expressing Trpγ^KK107656 under the control of any one of Scer\GAL4^elav.PU, Scer\GAL4^nan.PK or Scer\GAL4^iav.PU (neuronal drivers) have a significantly reduced ability to successfully traverse large gaps of 3.5mm compared to controls. This defect is also seen when Trpγ^KK107656 is expressed under the control of Scer\GAL4^nompA.cK, although the severity of the phenotype is less than that seen for any of the neuronal drivers.

Flies expressing Trpγ^KK107656 under the control of any one of Scer\GAL4^pyx.PS or Scer\GAL4^ato.PU show normal ability to successfully traverse large gaps of 3.5mm.

(Akitake et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v105280

P{KK107656}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Trpγ^KK107656

trpγ^KK107656

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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