FlyBase Gene Report: Dmel\brv1

General Information

Symbol

Dmel\brv1

Species

D. melanogaster

Name

brivido-1

Annotation Symbol

CG9472

Feature Type

protein_coding_gene

FlyBase ID

FBgn0036874

Gene Model Status

Current

Stock Availability

5 publicly available

Gene Summary

cation channel that mediates the mechanotransduction of class III dendritic arborization neurons of the PNS (Interactive Fly, brv1 )

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

76B3-76B3

Sequence location

3L:19,483,826..19,486,498 [-]

Recombination map

3-45

RefSeq locus

NT_037436 REGION:19483826..19486498

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables stretch-activated, monoatomic cation-selective, calcium channel activity

inferred from direct assay

(Zhang et al., 2018)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables calcium channel activity

inferred from biological aspect of ancestor with PANTHER:PTN000093539

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity

(Littleton and Ganetzky, 2000)

enables calcium ion binding

inferred from electronic annotation with InterPro:IPR003915

(InterPro Project Members, 2004-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in cellular response to cold

inferred from mutant phenotype

(Gallio et al., 2011)

involved_in detection of mechanical stimulus involved in sensory perception of touch

inferred from mutant phenotype

(Zhang et al., 2018)

involved_in detection of temperature stimulus involved in thermoception

inferred from mutant phenotype

(Gallio et al., 2011)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in calcium ion transport

inferred from sequence or structural similarity

(Littleton and Ganetzky, 2000)

involved_in detection of mechanical stimulus

inferred from biological aspect of ancestor with PANTHER:PTN000093539

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in membrane

inferred from biological aspect of ancestor with PANTHER:PTN000093539

(GO Reference Genome Project, 2011-)

located_in membrane

inferred from electronic annotation with InterPro:IPR003915

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

TRANSIENT RECEPTOR POTENTIAL ION CHANNELS

MECHANOSENSITIVE TRANSIENT RECEPTOR POTENTIAL ION CHANNELS

POLYCYSTIN CATION CHANNEL FAMILY

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

TRANSIENT RECEPTOR POTENTIAL ION CHANNELS -: The Transient Receptor Potential (TRP) channel family are cation channels conserved from invertebrates to humans. TRP channels respond to diverse stimuli and are involved in a number of environmental sensory pathways. (Adapted from FBrf0220930 and FBrf0225477).
MECHANOSENSITIVE TRANSIENT RECEPTOR POTENTIAL ION CHANNELS -: The Transient Receptor Potential (TRP) ion channels are cation channels. Some members of the TRP family have been shown to be gated by mechanical stimulation (Adapted from FBrf0248531.)
POLYCYSTIN CATION CHANNEL FAMILY -: Polycystin-related proteins are a family of proteins, some of which have been shown to be able to form cation-conducting transmembrane channels. In mammals, the polycystin complex is a heteromeric complex of the polycystin proteins, PKD1 (PC-1) and PKD2 (PC-2/TRPP1) that can act as a cation channel. Some members are also members of the Transient Receptor Potential (TRP) channel superfamily. (Adapted from FBrf0253843 and the Transporter Classification Database.)

Summary (Interactive Fly)

cation channel that mediates the mechanotransduction of class III dendritic arborization neurons of the PNS

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\brv1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VVZ8)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

brv1-RA

FBtr0074982

NM_140859

2673

728

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

brv1-PA

FBpp0074750

84.9

728

7.60

Q9VVZ8

NP_649116

AAF49157

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VVZ8

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\brv1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

brv1_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

4.47

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{GawB}NP4486

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

aristal sensory neuron VP3

(Ni et al., 2013, Gallio et al., 2011)

mechanosensory neuron | subset of second segment of antenna

(Gallio et al., 2011)

neuron of sacculus | subset

(Gallio et al., 2011)

antennal lobe glomerulus VP3

(Gallio et al., 2011)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\brv1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\brv1

View exonic expression by tissue for Dmel\brv1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40116/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0036874

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0036874

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0036874

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CR33940

Flygut - An atlas of the Drosophila adult midgut

FBgn0036874

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 3 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of brv1

Transgenic constructs containing regulatory region of brv1

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(3L)Exel9007

(Gallio et al., 2011, Ryder, 2004.4.26)

Df(3L)Exel9008

(Ryder, 2004.4.26)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

brv1^L563STOP

viable, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

brv1^GD2731

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

brv1^GD2731

viable, with Scer\GAL4^Mef2.PR

brv1^GD2731

viable, with Scer\GAL4^pnr-MD237

brv1^GD2731

viable, with Scer\GAL4^tin.CΔ4

brv1^GD2731

Other Phenotypes

Allele

abnormal cold stress response

brv1^NP4486

abnormal cold stress response (with Df(3L)Exel9007)

brv1^L563STOP

abnormal cold stress response | recessive

brv1^L563STOP

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (15)

Hsap\PKD1L3

4 of 14

Yes

Hsap\PKDREJ

4 of 14

Yes

Hsap\PKD1

3 of 14

Yes

Hsap\PKD1L1

3 of 14

Yes

Hsap\PKD1L2

3 of 14

Yes

3 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\TRPA1

1 of 14

Hsap\TRPC3

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (10)

Rnor\Pkdrej

4 of 14

Yes

Rnor\Pkd1l2

3 of 14

Yes

Rnor\Pkd1l3

3 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

Rnor\Trpa1

1 of 14

Mus musculus (laboratory mouse) (11)

Mmus\Pkdrej

4 of 14

Yes

Mmus\Pkd1l1

3 of 14

Yes

Mmus\Pkd1l2

3 of 14

Yes

Mmus\Pkd1l3

3 of 14

Yes

Mmus\Pkd1

3 of 14

Yes

3 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Yes

Mmus\Trpa1

1 of 14

Xenopus tropicalis (Western clawed frog) (8)

Xtro\pkd1l2

3 of 13

Yes

Xtro\LOC100496797

1 of 13

Xtro\nrp1

1 of 13

Yes

Xtro\pitpnc1l

1 of 13

Xtro\pkd1l1

1 of 13

Xtro\pkd1l3

1 of 13

Yes

Xtro\pkd1

1 of 13

Xtro\reep6

1 of 13

Danio rerio (Zebrafish) (10)

Drer\pkd1a

3 of 14

Yes

Drer\pkd1b

3 of 14

Yes

Drer\pkd1l2a

3 of 14

Yes

Drer\pkd1l2b

3 of 14

Yes

Drer\pkd2l1

3 of 14

Yes

Drer\pkd2

2 of 14

Drer\cacna1ba

1 of 14

Drer\loxhd1b

1 of 14

Yes

Drer\pkd1l1

1 of 14

Yes

Drer\pkd1l3

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (3)

Cele\lov-1

4 of 14

Yes

Cele\pkd-2

3 of 14

Cele\F27C1.11

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP004707

1 of 12

Yes

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:brv1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (11)

7 of 13

7 of 13

4 of 13

1 of 13

cac

1 of 13

CG30048

1 of 13

CG42685

1 of 13

para

1 of 13

PRY

1 of 13

TrpA1

1 of 13

trpl

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

PKD1; polycystin 1, transient receptor potential channel interacting

model of polycystic kidney disease 1

IEA

(FlyBase, 2019-)

PKD1L1; polycystin 1 like 1, transient receptor potential channel interacting

model of visceral heterotaxy 8

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PKD1L3; polycystin 1 like 3, transient receptor potential channel interacting

4 of 14

607895

PKDREJ; polycystin family receptor for egg jelly

4 of 14

604670

PKD1; polycystin 1, transient receptor potential channel interacting

3 of 14

601313

POLYCYSTIC KIDNEY DISEASE 1 WITH OR WITHOUT POLYCYSTIC LIVER DISEASE; PKD1

polycystic kidney disease 1

PKD1L1; polycystin 1 like 1, transient receptor potential channel interacting

3 of 14

609721

HETEROTAXY, VISCERAL, 8, AUTOSOMAL; HTX8

visceral heterotaxy 8

PKD1L2; polycystin 1 like 2 (gene/pseudogene)

3 of 14

607894

PKD2L1; polycystin 2 like 1, transient receptor potential cation channel

3 of 14

604532

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

65387

DroID - A comprehensive database of gene and protein interactions.

FBgn0036874

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

VxPx cargo-targeting to cilium

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-45

Cytogenetic map

76B3-76B3

Sequence location

3L:19,483,826..19,486,498 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

76B3-76B3

Limits computationally determined from genome sequence between P{EP}MESR6^EP3142 and P{lacW}l(3)L3809^L3809

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-45

(FlyBase, 2016)

3-42.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (5)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

31496

y¹ v¹; P{TRiP.JF02078}attP2

31506

y¹ v¹; P{TRiP.JF01061}attP2

31507

y¹ v¹; P{TRiP.JF01062}attP2

Kyoto

104694

y^* w^*; P{GawB}NP4486 / TM6, P{UAS-lacZ.UW23-1}UW23-1

VDRC

v8424

w¹¹¹⁸; P{GD2731}v8424

Genomic Clones (10)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (1)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

MIP06652

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0036874

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0036874

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: brv1 CG9472

(Gallio et al., 2011)

Nomenclature comments

Etymology

'brivido' is Italian for shiver, and mutants are deficient in sensing cold temperature.

(Gallio et al., 2011)

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

Brivido 1

(George and Stanewsky, 2021)

Brivido1

(Xiao and Xu, 2021)

Brv

(Suito and Tominaga, 2024)

Brv-1

(Su et al., 2018)

Brv1

(Suito and Tominaga, 2024, Liu and Zhang, 2022, Hehlert et al., 2021, Montell, 2021, Barbagallo and Garrity, 2015)

CG9472

(Tsubouchi et al., 2012, Gallio et al., 2011, Cooper et al., 2010, Ni et al., 2008)

CT26822

(Littleton and Ganetzky, 2000)

brv

(Neckameyer and Argue, 2013)

brv1

(Andreatta et al., 2025, Budelli et al., 2019, Zhang et al., 2018, Li and Gong, 2017, Ni et al., 2016, Gallio et al., 2011)

Name Synonyms

Brivido-1

(Bellemer, 2015)

brivido

(Neckameyer and Argue, 2013)

brivido-1

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 28 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40116

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

AAF49157

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VVZ8

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9VVZ8

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VVZ8

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40116/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0036874

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0036874

FlyMine - An integrated database for Drosophila genomics

FBgn0036874

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG9472

MARRVEL_MODEL - MARRVEL (model organism gene)

40116

Linkouts

BioGRID - A database of protein and genetic interactions.

65387

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0036874

DroID - A comprehensive database of gene and protein interactions.

FBgn0036874

DRSC - Results frm RNAi screens

FBgn0036874

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

brv1_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0036874

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0036874

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CR33940

Flygut - An atlas of the Drosophila adult midgut

FBgn0036874

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

VxPx cargo-targeting to cilium

References (40)

The following external sites may use different assemblies or annotations than FlyBase.

4.47

Report Sections