FlyBase Gene Report: Dmel\PRY

General Information

Symbol

Dmel\PRY

Species

D. melanogaster

Name

polycystine-related-Y

Annotation Symbol

CG45787

Feature Type

protein_coding_gene

FlyBase ID

FBgn0267489

Gene Model Status

Current

Stock Availability

4 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

Sequence location

Y:146,092..192,020 [-]

Recombination map

Y-

RefSeq locus

NC_024512 REGION:146092..192020

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

NCBI

UCSC

Ensembl

Function

Gene Ontology (GO) Annotations (0 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

POLYCYSTIN CATION CHANNEL FAMILY

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

POLYCYSTIN CATION CHANNEL FAMILY -: Polycystin-related proteins are a family of proteins, some of which have been shown to be able to form cation-conducting transmembrane channels. In mammals, the polycystin complex is a heteromeric complex of the polycystin proteins, PKD1 (PC-1) and PKD2 (PC-2/TRPP1) that can act as a cation channel. Some members are also members of the Transient Receptor Potential (TRP) channel superfamily. (Adapted from FBrf0253843 and the Transporter Classification Database.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\PRY for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 6.02

Low-frequency RNA-Seq exon junction(s) not annotated.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

PRY-RA

FBtr0346773

NM_001110656

3744

1247

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

PRY-PA

FBpp0312368

145.2

1247

7.70

A8QI68

NP_001104126

EDP27898

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

A8QI68

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\PRY using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

NA

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\PRY in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\PRY

View exonic expression by tissue for Dmel\PRY

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

26067055/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0267489

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0267489

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG45787
PRY

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 7 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 1 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of PRY

Transgenic constructs containing regulatory region of PRY

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Sterility

Allele

male fertile

male fertile, with Scer\GAL4^VP16.bam

PRY^HMJ22255

male semi-fertile

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (7)

Hsap\PKDREJ

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

Hsap\LOXHD1

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (6)

Rnor\Pkdrej

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

Mus musculus (laboratory mouse) (6)

Mmus\Pkdrej

3 of 14

Yes

Mmus\Pkd1l1

2 of 14

Mmus\Pkd1l2

2 of 14

Mmus\Loxhd1

1 of 14

Yes

Mmus\Pkd1l3

1 of 14

Mmus\Pkd1

1 of 14

Xenopus tropicalis (Western clawed frog) (7)

Xtro\LOC100496797

2 of 13

Yes

Xtro\pkd1l2

2 of 13

Yes

Xtro\loxhd1

1 of 13

Yes

Xtro\pkd1l1

1 of 13

Xtro\pkd1l3

1 of 13

Yes

Xtro\pkd1

1 of 13

Xtro\rp1

1 of 13

Yes

Danio rerio (Zebrafish) (8)

Drer\pkd1l2a

2 of 14

Yes

Drer\loxhd1a

1 of 14

Yes

Drer\loxhd1b

1 of 14

Yes

Drer\pkd1a

1 of 14

Drer\pkd1b

1 of 14

Drer\pkd1l1

1 of 14

Yes

Drer\pkd1l2b

1 of 14

Drer\pkd1l3

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\lov-1

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (0)

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:PRY. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (5)

5 of 13

4 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PKDREJ; polycystin family receptor for egg jelly

3 of 14

604670

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0267489

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene

nuclear_gene

(FlyBase Genome Annotators, 2009, Drosophila Heterochromatin Genome Project, 2007)

protein_coding_gene

(FlyBase Genome Annotators, 2009, Drosophila Heterochromatin Genome Project, 2007)

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

Y-

Cytogenetic map

Sequence location

Y:146,092..192,020 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Located in the kl-3 to kl-5 region.

(de Carvalho et al., 2000)

Experimentally Determined Recombination Data

Location

Y-

(de Carvalho et al., 2000)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (4)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

602712

PRY^G54.1

602713

PRY^G54.7

58235

y¹ v¹; P{TRiP.HMJ22255}attP40

NIG-Fly

HMJ22255

y¹ v¹; P{TRiP.HMJ22255}attP40/CyO

Genomic Clones (2)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (8)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

New annotation (CG42619) in release 5.21 of the genome annotation.

(FlyBase Genome Annotators, 2009)

New annotation (CG40930) in release 5.2 of the genome annotation.

(Drosophila Heterochromatin Genome Project, 2007)

New annotation (CG41367) in release 5.2 of the genome annotation.

(Drosophila Heterochromatin Genome Project, 2007)

Relationship to Other Genes

Source for database merge of

Source for merge of:CG41367 CG42619 CG40930

(FlyBase Genome Annotators, 2014)

Source for merge of:PRY CG45787

(FlyBase, 1996-)

Additional comments

Annotations CG41367, CG42619 and CG40930 merged as CG45787 in release 6.02 of the genome annotation. This gene is no longer fragmented in the release 6 genome assembly.

(FlyBase Genome Annotators, 2014)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Name Synonyms

polycystine-related-Y

(Hoskins et al., 2015)

Secondary FlyBase IDs

FBgn0044023
FBan0040930
FBgn0085538
FBgn0261334
FBan0041367
FBgn0085633
FBgn0267434

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 22 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

26067055

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

A8QI68

Other crossreferences

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

26067055/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0267489

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0267489

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG45787

MARRVEL_MODEL - MARRVEL (model organism gene)

26067055

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0267489

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0267489

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG45787
PRY

References (30)

The following external sites may use different assemblies or annotations than FlyBase.

NA

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