dgq, Gqα, Gα49B, Gq, Galpha49B
Stage-specific extension of 3' UTRs observed during embryogenesis (FBrf0215804); all variants may not be annotated.
5' UTR contains an ORF described as a putative conserved uORF (FBrf0204849); potential peptide 31aa in length.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.46
Gene model reviewed during 5.54
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gαq using the Feature Mapper tool.
RT-PCR analysis shows that the isoforms -RA, -RB, -RC, -RE, -RG and -RH of G-iα65A are expressed in the adult head, third segment of the antenna and maxillary palps. The isoform Gα49B-RD is only detected in the adult head.
Gα49B protein is localized to the photoreceptor cells of the retina. It is also detected in the lamina and the medulla, presumably in axons of the photoreceptor cells that project to these optic ganglia.
In adult head sections, this Gα49B protein isoform localizes to the third antennal segment, the maxillary palps, the tip of the proboscis, and the lamina. A subset of the staining detected in the third antennal segment localizes to olfactory neurons.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Gαq in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Alternative splicing of Gα49B RNA and the distribution of the various isoforms has been analysed.
Gα49B is essential for photoreceptor cell function, and functions as a molecular switch, reporting activity upstream in the signalling pathway.