FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Gαq
Open Close
General Information
Symbol
Dmel\Gαq
Species
D. melanogaster
Name
G protein alpha subunit q
Annotation Symbol
CG17759
Feature Type
protein_coding_gene
FlyBase ID
FBgn0004435
Gene Model Status
Current
Stock Availability
30 publicly available
Enzyme Name (EC)
Gene Summary
G protein α q subunit (Gαq) encodes an alpha subunit of a heterotrimeric G-protein that functions downstream of GPCR signaling. It contributes to neuronal development, olfaction, flight, learning and memory. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

dgq, Gqα, Gq, Gα49B, Galpha49B

Key Links
Genomic Location
Cytogenetic map
49B8-49B9
Sequence location
Recombination map
2-67
RefSeq locus
NT_033778 REGION:12612740..12623197
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (27 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables G protein activity
inferred from mutant phenotype
(Lee et al., 1994)
enables phospholipase activator activity
inferred from physical interaction with FLYBASE:norpA; FB:FBgn0262738
(Bahner et al., 2000)
inferred from genetic interaction with FLYBASE:rdgB; FB:FBgn0003218
(Lee et al., 1994)
inferred from genetic interaction with FLYBASE:norpA; FB:FBgn0262738
(Lee et al., 1994)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables G protein-coupled receptor binding
inferred from biological aspect of ancestor with PANTHER:PTN000026392
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR000654
(InterPro Project Members, 2004-)
enables G-protein beta/gamma-subunit complex binding
inferred from biological aspect of ancestor with PANTHER:PTN000026392
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR001019
(InterPro Project Members, 2004-)
enables GTPase activity
inferred from electronic annotation with InterPro:IPR000654, InterPro:IPR001019
(InterPro Project Members, 2004-)
inferred from sequence or structural similarity with MGI:MGI:95776
(Strathmann and Simon, 1990)
inferred from biological aspect of ancestor with PANTHER:PTN000026392
(GO Reference Genome Project, 2011-)
enables guanyl nucleotide binding
inferred from electronic annotation with InterPro:IPR001019
(InterPro Project Members, 2004-)
Biological Process (16 terms)
Terms Based on Experimental Evidence (12 terms)
CV Term
Evidence
References
involved_in axon midline choice point recognition
inferred from mutant phenotype
(Ratnaparkhi et al., 2002)
involved_in cellular response to carbon dioxide
inferred from mutant phenotype
(Yao and Carlson, 2010)
involved_in flight behavior
inferred from genetic interaction with FLYBASE:Itpr; FB:FBgn0010051
(Banerjee et al., 2006)
involved_in mucosal immune response
inferred from mutant phenotype
(Ha et al., 2009)
involved_in negative regulation of compound eye retinal cell programmed cell death
inferred from mutant phenotype
(Iakhine et al., 2004)
involved_in negative regulation of phospholipase C-activating phototransduction signaling pathway
inferred from mutant phenotype
(Hu et al., 2012)
involved_in neuron cellular homeostasis
inferred from genetic interaction with FLYBASE:GluRIIC; FB:FBgn0046113
(Brusich et al., 2015)
involved_in phospholipase C-activating opsin-mediated signaling pathway
inferred from mutant phenotype
(Cao et al., 2018, Han et al., 2007, Lee et al., 1994)
inferred from direct assay
(Elia et al., 2005)
involved_in regulation of neuromuscular synaptic transmission
inferred from genetic interaction with FLYBASE:GluRIIC; FB:FBgn0046113
(Brusich et al., 2015)
involved_in sensory perception of smell
inferred from mutant phenotype
(Kain et al., 2008)
involved_in stabilization of membrane potential
inferred from genetic interaction with FLYBASE:Itpr; FB:FBgn0010051
(Banerjee et al., 2006)
involved_in thermotaxis
inferred from mutant phenotype
(Shen et al., 2011)
inferred from direct assay
(Kwon et al., 2008)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN000026392
(GO Reference Genome Project, 2011-)
involved_in G protein-coupled receptor signaling pathway
inferred from electronic annotation with InterPro:IPR000654, InterPro:IPR001019
(InterPro Project Members, 2004-)
involved_in phototransduction
traceable author statement
(Montell, 1999)
involved_in signal transduction
inferred from electronic annotation with InterPro:IPR011025
(InterPro Project Members, 2004-)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
part_of inaD signaling complex
inferred from direct assay
(Bahner et al., 2000)
located_in plasma membrane
inferred from high throughput direct assay
(Tan et al., 2009)
located_in rhabdomere
inferred from direct assay
(Lee et al., 1994)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000026392
(GO Reference Genome Project, 2011-)
part_of heterotrimeric G-protein complex
inferred from sequence or structural similarity with MGI:MGI:95776
(Strathmann and Simon, 1990)
inferred from biological aspect of ancestor with PANTHER:PTN000026392
(GO Reference Genome Project, 2011-)
located_in rhabdomere
traceable author statement
(Montell, 1999)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the G-alpha family. G(q) subfamily. (P23625)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
GTPase activity
RHEA 19669: G protein activity
Summaries
Gene Snapshot
G protein α q subunit (Gαq) encodes an alpha subunit of a heterotrimeric G-protein that functions downstream of GPCR signaling. It contributes to neuronal development, olfaction, flight, learning and memory. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
HETEROTRIMERIC G-PROTEIN ALPHA SUBUNITS -
The Heterotrimeric G-protein alpha subunits (Gα) can bind guanine nucleotide. When inactive, Gα is bound to GDP and associates with Gβγ forming an heterotrimer. Upon GTP binding, Gα dissociates from the heterotrimer Gαβγ. Gα has an intrinsic guanosine triphosphatase (GTPase) activity. (Adapted from FBrf0209904 and FBrf0183798).
Protein Function (UniProtKB)
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Could be the transducin analog, an amplifier and one of the transducers of a visual impulse that performs the coupling between opsin and cGMP-phosphodiesterase. Could mediate a subset of olfactory and gustatory responses.
(UniProt, P23625)
Summary (Interactive Fly)

splice variants play roles in phototransduction, retinal integrity and function in rhodopsin synthesis - regulation of wing growth - regulation of nociceptor sensitivity in larvae - DAMB signals via Gq to mediate forgetting in Drosophila - regulation of dendritic growth - regulation of sensitivity to ethanol - control of body fat storage - Regulates of dual oxidase activity in Drosophila gut immunity - modulation of axonal pathfinding

Gene Model and Products
Number of Transcripts
7
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\Gαq for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P23625)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Stage-specific extension of 3' UTRs observed during embryogenesis (FBrf0215804); all variants may not be annotated.

5' UTR contains an ORF described as a putative conserved uORF (FBrf0204849); potential peptide 31aa in length.

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.46

Gene model reviewed during 5.54

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Gαq-RA
FBtr0087829
NM_165919
3050
353
Gαq-RC
FBtr0087831
NM_165921
3660
353
Gαq-RD
FBtr0087832
NM_165924
1615
353
Gαq-RE
FBtr0087833
NM_165922
3509
353
Gαq-RG
FBtr0087830
NM_165923
3017
353
Gαq-RJ
FBtr0333101
NM_165920
1813
396
Gαq-RK
FBtr0304955
NM_165925
5648
353
Additional Transcript Data and Comments
Reported size (kB)

3.549 (longest cDNA)

(Talluri et al., 1995)

1.8 (northern blot)

(Lee et al., 1990)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Gαq-PA
FBpp0086942
41.6
353
4.83
NP_725191
AAF58485
Gαq-PC
FBpp0086944
41.6
353
4.83
NP_725193
AAM68627
Gαq-PD
FBpp0086945
41.3
353
4.94
P23625
NP_725196
AAM68631
Gαq-PE
FBpp0086946
41.6
353
4.83
NP_725194
AAM68628
Gαq-PG
FBpp0086943
41.6
353
4.83
NP_725195
AAM68629
Gαq-PJ
FBpp0305314
46.4
396
4.64
NP_725192
AAG22276
Gαq-PK
FBpp0293494
41.6
353
4.83
NP_725197
AAM68632
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

353 aa isoforms: Gαq-PA, Gαq-PC, Gαq-PE, Gαq-PG, Gαq-PK
Additional Polypeptide Data and Comments
Reported size (kDa)

353 (aa)

(Talluri et al., 1995)

317 (aa); 41.3, 37.2 (kD predicted)

(Lee et al., 1990)
Comments

Gβ76C protein, Gα49B protein, and Gγ30A protein are all expressed in the same pattern supporting the hypothesis that Gγ30A is part of a heterotrimeric eye-specific G protein.

(Schulz et al., 1999)
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gαq using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.03

Transcript Expression
expression microarray
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
eye
(Xu et al., 2004)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
head mesoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 9 -- 17
organism

Comment: extended 3' UTR isoform

(Hilgers et al., 2011)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
Bolwig organ
(Fisher et al., 2012)
embryonic brain
(Fisher et al., 2012)
embryonic foregut
(Fisher et al., 2012)
embryonic head sensory system
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
larval nervous system
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
embryonic stage 13 -- 17
presumptive embryonic/larval central nervous system
(Ratnaparkhi et al., 2002)
embryonic stage 16 -- 17
Bolwig organ
(Ratnaparkhi et al., 2002)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
retina
(Lee et al., 1990)
adult head
(Lee et al., 1990)
ocellus
(Lee et al., 1990)
pcr
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain
(Alvarez et al., 1996)
eye
(Alvarez et al., 1996)
ocellus
(Alvarez et al., 1996)
(Alvarez et al., 1996)
spermatogenesis & adult stage
testis
(Alvarez et al., 1996)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism
(Ratnaparkhi et al., 2002)
adult stage | male
organism
(Ratnaparkhi et al., 2002)
testis
(McGurk et al., 2008)
adult stage | female
organism
(Ratnaparkhi et al., 2002)
adult stage
adult head

Comment: all isoforms

(Boto et al., 2010, Ratnaparkhi et al., 2002)
appendage
(Ratnaparkhi et al., 2002)
third segment of antenna

Comment: all isoforms except Gq-RD (Gα49B-RD)

(Boto et al., 2010)
maxillary palp

Comment: all isoforms except Gq-RD (Gα49B-RD)

(Boto et al., 2010)
antenna
(Yao and Carlson, 2010)
labellum
(Bredendiek et al., 2011)
Additional Descriptive Data

Zygotic-specific isoforms of Gαq with long 3' UTR extensions were observed.

(Hilgers et al., 2011)

RT-PCR analysis shows that the isoforms -RA, -RB, -RC, -RE, -RG and -RH of G-iα65A are expressed in the adult head, third segment of the antenna and maxillary palps. The isoform Gα49B-RD is only detected in the adult head.

(Boto et al., 2010)

Eye-enriched transcripts determined by ratio of expression level in wild-type heads. versus expression level in so heads.

(Xu et al., 2004)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 12 -- 13
epithelium of embryonic/larval midgut primordium
(Ratnaparkhi et al., 2002)
embryonic stage 12 -- 17
presumptive embryonic/larval central nervous system
(Ratnaparkhi et al., 2002)
embryonic stage 13 -- 17
embryonic fiber tract
(Ratnaparkhi et al., 2002)
pupal stage P6 -- adult stage
adult olfactory receptor neuron
(Kain et al., 2008)
antenna | restricted
(Kain et al., 2008)
third segment of antenna | restricted
(Kain et al., 2008)
adult stage
rhabdomere
(Lee et al., 1994)
lamina
(Astorga et al., 2012, Schulz et al., 1999, Talluri et al., 1995)
eye
(Lee et al., 1994)
ocellus
(Lee et al., 1994)
photoreceptor neuron
(Bernardo-Garcia et al., 2016, Schulz et al., 1999)
third segment of antenna
(Talluri et al., 1995)
proboscis | restricted
(Talluri et al., 1995)
maxillary palp
(Talluri et al., 1995)
medulla
(Schulz et al., 1999)
third segment of antenna | restricted
(Boto et al., 2010)
olfactory sensory organ | subset
(Boto et al., 2010)
photoreceptor
(Astorga et al., 2012)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 5 of adulthood | male -- day 7 of adulthood | male
spermatozoon
(Dorus et al., 2006)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism
(Ratnaparkhi et al., 2002)
adult stage
head
(Ratnaparkhi et al., 2002)
adult head
(Tian et al., 2013)
Additional Descriptive Data

Gα49B protein is expressed in the neurons, neuronal processes and non-neuronal tissues of the third segment of the antenna. It co-localises with G-iα65A protein.

(Boto et al., 2010)

Gα49B protein is localized to the photoreceptor cells of the retina. It is also detected in the lamina and the medulla, presumably in axons of the photoreceptor cells that project to these optic ganglia.

(Schulz et al., 1999)

In adult head sections, this Gα49B protein isoform localizes to the third antennal segment, the maxillary palps, the tip of the proboscis, and the lamina. A subset of the staining detected in the third antennal segment localizes to olfactory neurons.

(Talluri et al., 1995)

Gα49B proteins are detected in all rhabdomeres of the eye, and in ocelli.

(Lee et al., 1994)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of inaD signaling complex
inferred from direct assay
(Bahner et al., 2000)
located_in plasma membrane
inferred from high throughput direct assay
(Tan et al., 2009)
located_in rhabdomere
inferred from direct assay
(Lee et al., 1994)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Gαq in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 9-10
  • Stages(s) 11-12
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 13 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 31 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Gαq
Transgenic constructs containing regulatory region of Gαq
Aberrations (Deficiencies and Duplications) ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal (with Df(2R)vg-C)
lethal (with Gαq221c)
lethal (with Gαq1370)
lethal | recessive
lethal - all die before end of first instar larval stage
lethal - all die before end of larval stage | recessive
partially lethal - majority die, with Scer\GAL4phtm.PO
viable (with Gαq1)
viable (with Gαq221c)
viable (with Gαq1370)
Other Phenotypes
Allele
abnormal behavior | recessive
abnormal chemosensory behavior | adult stage
abnormal chemosensory behavior | adult stage, with Scer\GAL4Orco.2.642.Hsim\VP22
abnormal chemosensory behavior | adult stage, with Scer\GAL4TrpA1.PR
abnormal immune response
abnormal neuroanatomy, with Scer\GAL4ap-md544
abnormal neuroanatomy, with Scer\GAL4elav-C155
abnormal neuroanatomy, with Scer\GAL4ftz.ng
abnormal neuroanatomy | embryonic stage, with Scer\GAL415J2
abnormal neuroanatomy | third instar larval stage
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4unspecified
abnormal neurophysiology
abnormal neurophysiology, with Scer\GAL4GMR.PF
abnormal neurophysiology, with Scer\GAL4Gαq.PS
abnormal neurophysiology, with Scer\GAL4hs.PB
abnormal neurophysiology, with Scer\GAL4Orco.2.642.Hsim\VP22
abnormal neurophysiology (with Df(2R)Exel7121)
abnormal neurophysiology (with Gαq1)
abnormal neurophysiology (with Gαq961)
abnormal neurophysiology | adult stage
abnormal neurophysiology | adult stage (with Df(2R)Exel7121)
abnormal neurophysiology | adult stage (with Df(2R)Gαq1.3)
abnormal neurophysiology | adult stage (with Gαq1)
abnormal neurophysiology | adult stage (with GαqV303D)
abnormal neurophysiology | dominant
abnormal neurophysiology | heat sensitive, with Scer\GAL4hs.PU
abnormal neurophysiology | recessive, with Scer\GAL4Gr21a.PC
abnormal neurophysiology | somatic clone
abnormal sensory perception, with Scer\GAL4Gr21a.9.323
abnormal smell perception, with Scer\GAL4c309
abnormal smell perception, with Scer\GAL4Gr21a.PC
abnormal smell perception, with Scer\GAL4Mef2.247
abnormal smell perception, with Scer\GAL4Tab2-201Y
abnormal smell perception, with Scer\GAL4VP16.Orco
abnormal smell perception | heat sensitive, with Scer\GAL4hs.PU
abnormal smell perception | heat sensitive, with Scer\GAL80ts.αTub84B
abnormal thermotaxis
abnormal thermotaxis, with Scer\GAL4TrpA1.PR
abnormal thermotaxis | larval stage, with Scer\GAL4ninaE.PT
abnormal thermotaxis | third instar larval stage
abnormal thermotaxis | third instar larval stage, with Scer\GAL4Rh5-G
abnormal thermotaxis | third instar larval stage, with Scer\GAL4Rh6-G
abnormal thermotaxis | third instar larval stage, with Scer\GAL4TrpA1-AB-G4
abnormal thermotaxis | third instar larval stage, with Scer\GAL4TrpA1-CD-G4
abnormal visual behavior | recessive
flightless | partially, with Scer\GAL4Ddc.PL
majority die during larval stage, with Scer\GAL4phtm.PO
short lived | nutrition conditional
some die during first instar larval stage
some die during larval stage | recessive
visible | adult stage | light conditional | progressive, with Scer\GAL4ninaE.PT
wild-type
Phenotype manifest in
Allele
adult antennal lobe receptor neuron
adult olfactory receptor neuron Gr21a/63a, with Scer\GAL4Gr21a.9.323
adult olfactory receptor neuron Gr21a/63a | heat sensitive, with Scer\GAL4hs.PU
adult olfactory receptor neuron Or22, with Scer\GAL4VP16.Orco
adult olfactory receptor neuron Or42b, with Scer\GAL4VP16.Orco
adult olfactory receptor neuron Or59b, with Scer\GAL4Gαq.PS
adult olfactory receptor neuron Or59b, with Scer\GAL4VP16.Orco
adult olfactory receptor neuron Or59b | somatic clone
axon | third instar larval stage
axon | third instar larval stage, with Scer\GAL4unspecified
dMP2 neuron, with Scer\GAL415J2
embryonic/larval neuromuscular junction | third instar larval stage
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4unspecified
eye photoreceptor cell
fascicle | embryonic stage, with Scer\GAL4ap-md544
fascicle | embryonic stage, with Scer\GAL4elav-C155
fascicle | embryonic stage, with Scer\GAL4ftz.ng
neuropil | embryonic stage, with Scer\GAL4elav-C155
ommatidium | light conditional, with Scer\GAL4ninaE.PT
pCC neuron, with Scer\GAL4ftz.ng
photoreceptor
photoreceptor neuron
photoreceptor neuron, with Scer\GAL4GMR.PF
pupa, with Scer\GAL4CCAP.PP
pupa, with Scer\GAL4Lk.PM
retina | adult stage
retina | conditional
rhabdomere
rhabdomere | adult stage
rhabdomere | decreased number | light conditional, with Scer\GAL4ninaE.PT
symmetrical commissure | embryonic stage, with Scer\GAL4elav-C155
wing, with Scer\GAL4Ddc.PL
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (22)
Hsap\GNAQ
11 of 14
Yes
Yes
Hsap\GNA11
10 of 14
No
Yes
1  
Hsap\GNA14
10 of 14
No
Yes
Hsap\GNA15
5 of 14
No
No
Hsap\GNAI2
5 of 14
No
No
Hsap\GNAI3
5 of 14
No
No
Hsap\GNAO1
5 of 14
No
No
4  
Hsap\GNAT1
5 of 14
No
No
Hsap\GNAT2
5 of 14
No
No
Hsap\GNAT3
5 of 14
No
No
Hsap\GNAZ
5 of 14
No
No
1  
Hsap\GNA12
4 of 14
No
No
Hsap\GNA13
4 of 14
No
No
1  
Hsap\GNAI1
4 of 14
No
No
Hsap\GNAL
2 of 14
No
No
Hsap\GNAS
2 of 14
No
No
2  
Hsap\ARF4
1 of 14
No
No
Hsap\ARF5
1 of 14
No
No
1  
Hsap\ARF6
1 of 14
No
No
1  
Hsap\ARL1
1 of 14
No
No
Hsap\ARL2
1 of 14
No
No
Hsap\SAR1B
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (16)
Rnor\Gnaq
12 of 14
Yes
Yes
Rnor\Gna11
10 of 14
No
Yes
Rnor\Gna14
10 of 14
No
Yes
Rnor\Gna15
5 of 14
No
No
Rnor\Gnai2
5 of 14
No
No
Rnor\Gnai3
5 of 14
No
No
Rnor\Gnao1
5 of 14
No
No
Rnor\Gnat1
5 of 14
No
No
Rnor\Gnat2
5 of 14
No
No
Rnor\Gnat3
5 of 14
No
No
Rnor\Gnaz
5 of 14
No
No
Rnor\Gna12
4 of 14
No
No
Rnor\Gna13
4 of 14
No
No
Rnor\Gnai1
4 of 14
No
No
Rnor\Gnal
1 of 14
No
No
Rnor\Gnas
1 of 14
No
No
Mus musculus (laboratory mouse) (16)
Mmus\Gnaq
12 of 14
Yes
Yes
Mmus\Gna11
10 of 14
No
Yes
Mmus\Gna14
10 of 14
No
Yes
Mmus\Gna15
5 of 14
No
No
Mmus\Gnai1
5 of 14
No
No
Mmus\Gnai2
5 of 14
No
No
Mmus\Gnai3
5 of 14
No
No
Mmus\Gnat1
5 of 14
No
No
Mmus\Gnat2
5 of 14
No
No
Mmus\Gnat3
5 of 14
No
No
Mmus\Gnaz
5 of 14
No
No
Mmus\Gna12
4 of 14
No
No
Mmus\Gna13
4 of 14
No
No
Mmus\Gnao1
4 of 14
No
No
Mmus\Gnal
2 of 14
No
No
Mmus\Gnas
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (18)
Xtro\gnaq
9 of 13
Yes
Yes
Xtro\vwa1
6 of 13
No
Yes
Xtro\gna11
5 of 13
No
Yes
Xtro\gna14
5 of 13
No
Yes
Xtro\mcoln2
5 of 13
No
No
Xtro\gna15
4 of 13
No
No
Xtro\gnai3
4 of 13
No
No
Xtro\gnao1
4 of 13
No
No
Xtro\gnat1
4 of 13
No
No
Xtro\gnat2
4 of 13
No
No
Xtro\gna13
3 of 13
No
No
Xtro\gnai1
2 of 13
No
No
Xtro\gnai2
2 of 13
No
No
Xtro\gnaz
2 of 13
No
No
Xtro\slc66a1
2 of 13
No
No
Xtro\fdx1
1 of 13
No
No
Xtro\lyve1
1 of 13
No
Yes
Xtro\sar1b
1 of 13
No
No
Danio rerio (Zebrafish) (28)
Drer\gna11a
11 of 14
Yes
Yes
Drer\gna11b
11 of 14
Yes
Yes
Drer\gnaq
11 of 14
Yes
Yes
Drer\gna14a
5 of 14
No
No
Drer\gna14
5 of 14
No
No
Drer\gnai1
5 of 14
No
No
Drer\gnai2a
5 of 14
No
No
Drer\gnai2b
5 of 14
No
No
Drer\gnai3
5 of 14
No
No
Drer\gnaia
5 of 14
No
No
Drer\gnao1b
5 of 14
No
No
Drer\gnat1
5 of 14
No
No
Drer\gnat2
5 of 14
No
No
Drer\gnav1
5 of 14
No
No
Drer\gna12a
4 of 14
No
No
Drer\gna13a
4 of 14
No
No
Drer\gna13b
4 of 14
No
No
Drer\gna15.1
4 of 14
No
No
Drer\gna15.3
4 of 14
No
No
Drer\gnao1a
4 of 14
No
No
Drer\gnaz
4 of 14
No
No
Drer\gna15.4
3 of 14
No
No
Drer\gnal
2 of 14
No
No
Drer\LOC797518
2 of 14
No
No
Drer\gnal2
1 of 14
No
Yes
Drer\gnas
1 of 14
No
No
Drer\LOC108179047
1 of 14
No
No
Drer\si:ch211-207c7.2
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (26)
Cele\egl-30
10 of 14
Yes
Yes
Cele\goa-1
5 of 14
No
No
Cele\gpa-2
5 of 14
No
No
Cele\gpa-3
5 of 14
No
No
Cele\gpa-4
5 of 14
No
No
Cele\gpa-7
5 of 14
No
No
Cele\gpa-8
5 of 14
No
No
Cele\gpa-15
5 of 14
No
No
Cele\gpa-16
5 of 14
No
No
Cele\odr-3
5 of 14
No
No
Cele\gpa-1
4 of 14
No
No
Cele\gpa-6
4 of 14
No
No
Cele\gpa-10
4 of 14
No
No
Cele\gpa-12
4 of 14
No
No
Cele\gpa-5
3 of 14
No
No
Cele\gpa-9
3 of 14
No
No
Cele\gpa-11
3 of 14
No
No
Cele\gpa-13
2 of 14
No
No
Cele\gpa-14
2 of 14
No
No
Cele\gpa-17
2 of 14
No
No
Cele\gpa-18
2 of 14
No
No
Cele\gsa-1
2 of 14
No
No
Cele\arf-1
1 of 14
No
No
Cele\arf-5
1 of 14
No
No
Cele\arl-13
1 of 14
No
Yes
Cele\sar-1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (8)
Agam\AgaP_AGAP005079
10 of 12
Yes
Yes
Agam\AgaP_AGAP005904
5 of 12
No
No
Agam\AgaP_AGAP005773
4 of 12
No
No
Agam\AgaP_AGAP009457
4 of 12
No
No
Agam\AgaP_AGAP006521
2 of 12
No
No
Agam\GNAS_ANOGA
2 of 12
No
No
Agam\AgaP_AGAP004098
1 of 12
No
No
Agam\AgaP_AGAP006890
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (14)
Atha\GP ALPHA 1
9 of 13
Yes
No
Atha\XLG1
3 of 13
No
No
Atha\XLG2
3 of 13
No
No
Atha\XLG3
3 of 13
No
No
Atha\ARF1
1 of 13
No
No
Atha\ARFA1D
1 of 13
No
No
Atha\ARFA1E
1 of 13
No
No
Atha\ARFA1F
1 of 13
No
No
Atha\ARFB1B
1 of 13
No
No
Atha\AT3G62560
1 of 13
No
No
Atha\AT5G05670
1 of 13
No
No
Atha\SAR1B
1 of 13
No
No
Atha\SAR2
1 of 13
No
No
Atha\SARA1A
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (8)
Scer\GPA2
7 of 13
Yes
No
Scer\GPA1
5 of 13
No
No
Scer\ARF1
1 of 13
No
No
Scer\ARF2
1 of 13
No
No
Scer\ARF3
1 of 13
No
No
Scer\ARL3
1 of 13
No
No
Scer\CIN4
1 of 13
No
No
Scer\SAR1
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\gpa1
7 of 12
Yes
No
Spom\gpa2
7 of 12
Yes
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Gαq. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (9)
CG17760
9 of 13
Gαi
9 of 13
Gαo
9 of 13
CG30054
8 of 13
Gαs
7 of 13
cta
5 of 13
Gαf
4 of 13
Arf6
1 of 13
dnd
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
GαqJF02464
model of  obesity
CEA
(Baumbach et al., 2014)
Potential Models Based on Orthology ( 4 )
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
GNAQ; G protein subunit alpha q
11 of 14
600998
GNA11; G protein subunit alpha 11
10 of 14
139313
 
GNA14; G protein subunit alpha 14
10 of 14
604397
      GNA15; G protein subunit alpha 15
      5 of 14
      139314
          GNAI2; G protein subunit alpha i2
          5 of 14
          139360
            GNAI3; G protein subunit alpha i3
            5 of 14
            139370
              GNAO1; G protein subunit alpha o1
              5 of 14
              GUANINE NUCLEOTIDE-BINDING PROTEIN, ALPHA-ACTIVATING ACTIVITY POLYPEPTIDE O; GNAO1
               
              GNAT1; G protein subunit alpha transducin 1
              5 of 14
              139330
              GNAT2; G protein subunit alpha transducin 2
              5 of 14
              139340
              GNAT3; G protein subunit alpha transducin 3
              5 of 14
              139395
                  GNAZ; G protein subunit alpha z
                  5 of 14
                  139160
                       
                      GNA12; G protein subunit alpha 12
                      4 of 14
                      604394
                          GNA13; G protein subunit alpha 13
                          4 of 14
                          604406
                               
                              GNAI1; G protein subunit alpha i1
                              4 of 14
                              139310
                                Functional Complementation Data
                                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                Interactions
                                Summary of Physical Interactions
                                Summary of Genetic Interactions
                                Interaction Browsers
                                View in FlyBase Interactions Browser   View in MIST tool (external link)
                                Please look at the allele data for full details of the genetic interactions
                                Starting gene(s)
                                Interaction type
                                Interacting gene(s)
                                Reference
                                rdgC|Gαq
                                enhanceable
                                Arr2
                                (Kiselev et al., 2000)
                                Gαq|rdgC
                                suppressible
                                Arr2
                                (Kiselev et al., 2000)
                                Gαq
                                suppressible
                                fra
                                (Hiramoto and Hiromi, 2006, Ratnaparkhi et al., 2002)
                                Gαq
                                enhanceable
                                fra
                                (Ratnaparkhi et al., 2002)
                                Gαq
                                suppressible
                                Gβ76C
                                (Elia et al., 2005)
                                Gαq
                                suppressible
                                Itpr
                                (Yamanaka et al., 2015)
                                Gαq
                                suppressible
                                PIP5K59B
                                (Kumari et al., 2022)
                                Gαq
                                enhanceable
                                Plc21C
                                (Kain et al., 2008)
                                Itpr|Gαq
                                enhanceable
                                Plc21C
                                (Banerjee et al., 2006)
                                Gαq
                                suppressible
                                Rab3
                                (Yamanaka et al., 2015)
                                Gαq
                                suppressible
                                rdgA
                                (Hardie et al., 2002)
                                Gαq
                                suppressible
                                robo1
                                (Hiramoto and Hiromi, 2006, Ratnaparkhi et al., 2002)
                                Gαq
                                enhanceable
                                robo1
                                (Ratnaparkhi et al., 2002)
                                Itpr|Gαq
                                suppressible
                                SERCA
                                (Banerjee et al., 2006)
                                Plc21C|Itpr|Gαq
                                suppressible
                                SERCA
                                (Banerjee et al., 2006)
                                Gαq
                                suppressible
                                stac
                                (Yamanaka et al., 2015)
                                Gαq
                                suppressible
                                Syt1
                                (Yamanaka et al., 2015)
                                Starting gene(s)
                                Interaction type
                                Interacting gene(s)
                                Reference
                                Arr2
                                suppressible
                                Gαq
                                (Kiselev et al., 2000)
                                cac
                                enhanceable
                                Gαq
                                (Brusich et al., 2018)
                                Camta
                                suppressible
                                Gαq
                                (Han et al., 2006)
                                Gβ76C
                                suppressible
                                Gαq
                                (Elia et al., 2005)
                                Itpr
                                enhanceable
                                Gαq
                                (Banerjee et al., 2006)
                                ninaE
                                suppressible
                                Gαq|Arr2
                                (Iakhine et al., 2004)
                                ninaE
                                suppressible
                                Gαq
                                (Iakhine et al., 2004)
                                Plc21C
                                enhanceable
                                Gαq
                                (Kain et al., 2008)
                                rdgA
                                suppressible
                                Gαq
                                (Kain et al., 2008, Georgiev et al., 2005)
                                robo1
                                enhanceable
                                Gαq
                                (Ratnaparkhi et al., 2002)
                                tadr
                                suppressible
                                Gαq
                                (Ni et al., 2008)
                                External Data
                                Linkouts
                                BioGRID - A database of protein and genetic interactions.
                                DroID - A comprehensive database of gene and protein interactions.
                                MIST (genetic) - An integrated Molecular Interaction Database
                                MIST (protein-protein) - An integrated Molecular Interaction Database
                                Pathways
                                Signaling Pathways (FlyBase)
                                Metabolic Pathways
                                FlyBase
                                External Links
                                Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
                                External Data
                                Class of Gene
                                Genomic Location and Detailed Mapping Data
                                Chromosome (arm)
                                2R
                                Recombination map
                                2-67
                                Cytogenetic map
                                49B8-49B9
                                Sequence location
                                FlyBase Computed Cytological Location
                                Cytogenetic map
                                Evidence for location
                                49B8-49B9
                                Limits computationally determined from genome sequence between P{EP}AmphEP2175&P{lacW}spt4k05316 and P{PZ}ox1
                                Experimentally Determined Cytological Location
                                Cytogenetic map
                                Notes
                                References
                                49B-49B
                                (determined by in situ hybridisation)
                                (Lee et al., 1990)
                                Experimentally Determined Recombination Data
                                Location

                                2-67

                                (FlyBase, 2016)

                                2-69.7

                                (Comeron et al., 2012)
                                Left of (cM)
                                Right of (cM)
                                Notes
                                Stocks and Reagents
                                Stocks (30)
                                Genomic Clones (19)
                                cDNA Clones (227)
                                 

                                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                cDNA clones, fully sequenced
                                BDGP DGC clones
                                Other clones
                                Drosophila Genomics Resource Center cDNA clones

                                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                cDNA Clones, End Sequenced (ESTs)
                                BDGP DGC clones
                                Other clones
                                RNAi and Array Information
                                Linkouts
                                DRSC - Results frm RNAi screens
                                Antibody Information
                                Laboratory Generated Antibodies
                                 

                                polyclonal

                                (Katz and Minke, 2012, Rosenbaum et al., 2012, Talluri et al., 1995, Lee et al., 1994)
                                Commercially Available Antibodies
                                 
                                Cell Line Information
                                Publicly Available Cell Lines
                                 
                                  Other Stable Cell Lines
                                   
                                    Other Comments

                                    Galpha49B signaling mediates odor identity discrimination in naive flies.

                                    (Xia and Tully, 2007)

                                    Excess of Gβ76C over Gα49B prevents dark, spontaneous activity of photoreceptors.

                                    (Elia et al., 2005)

                                    Gα49B is necessary for light-dependent architectural changes in the eye.

                                    (Kosloff et al., 2003)

                                    dsRNA made from templates generated with primers against this gene tested in a cl-8 cell reporter assay to examine any role of Gα49B in the hh signalling pathway.

                                    (Lum, 2003)

                                    Alternative splicing of Gα49B RNA and the distribution of the various isoforms has been analysed.

                                    (Alvarez et al., 1996)

                                    Gα49B is essential for photoreceptor cell function, and functions as a molecular switch, reporting activity upstream in the signalling pathway.

                                    (Scott et al., 1995)

                                    Gα49B mediates the stimulation by light-activated rhodopsin of the norpA-encoded phospholipase C in the visual transduction cascade.

                                    (Lee et al., 1994)

                                    Gα49B has been cloned and sequenced.

                                    (Lee et al., 1990)

                                    A Gα49B cDNA has been cloned and sequenced.

                                    (Strathmann and Simon, 1990)
                                    Relationship to Other Genes
                                    Source for database merge of
                                    Additional comments

                                    One or more of the processed transcripts for this gene contain(s) two non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by Gαq and CG45086.

                                    (FlyBase Genome Annotators, 2013)
                                    Nomenclature History
                                    Source for database identify of

                                    Source for identity of: Gα49B CG17759

                                    (Gabrielian, 1999.11)

                                    Source for identity of: Gαq Gα49B

                                    (FlyBase, 2009-)
                                    Nomenclature comments

                                    Genes encoding Gα subunits that have been named for their molecular function/orthology have had their symbols and names standardized following the format used in FBrf0220456, which also reflects popular usage in the Drosophila literature.

                                    (FlyBase, 2009-)
                                    Etymology
                                    Synonyms and Secondary IDs (55)
                                    Reported As
                                    Symbol Synonym
                                    CG17759
                                    (Aradska et al., 2015, Hanlon and Andrew, 2015, Rosa-Ferreira et al., 2015, Chen et al., 2012, Jaspers et al., 2012, Cammarato et al., 2011, Ni et al., 2011.7.19, Boto et al., 2010, Khanna et al., 2010, Ni et al., 2010.12.1, Zhang et al., 2010, Keleman et al., 2009.8.5, Ni et al., 2009, Perkins et al., 2009, Hayden and Bosco, 2008, Ni et al., 2008, Goldman and Arbeitman, 2007, Colicelli, 2004, Adams, 2002, Labourier et al., 2002)
                                    DGq
                                    (Huber et al., 1999, Hasan, 1998, Running Deer et al., 1995, Hyde et al., 1991)
                                    DGqα
                                    (Kosloff et al., 2003, Hyde et al., 1991, Strathmann and Simon, 1990)
                                    DGαq
                                    DGαq
                                    (Hyde et al., 1993)
                                    Dgq
                                    (Tsunoda et al., 2001, Vinos et al., 1997, Yarfitz et al., 1994, Yarfitz et al., 1993)
                                    DmGαq
                                    (Bahner et al., 2000)
                                    Dromel_CG17759_galpha49b_mORF
                                    (Hayden and Bosco, 2008)
                                    G alpha 49B
                                    (Adams, 2002)
                                    Gaq
                                    (Kosloff et al., 2003)
                                    Gq
                                    (Astorga et al., 2012, Boto et al., 2010, Georgiev et al., 2005, Hardie, 2003, Voets and Nilius, 2003, Venkatachalam et al., 2002, Hardie, 2001, Liu et al., 2000)
                                    Gqα
                                    (Rosenbaum et al., 2014, Rosenbaum et al., 2011, Frechter et al., 2007, Cronin et al., 2004, Iakhine et al., 2004, Hardie, 2001)
                                    Gqα
                                    (Tsunoda et al., 1997)
                                    Gαq
                                    (Leung et al., 2020, Vasiliauskas et al., 2011, Ni et al., 2008, Han et al., 2007, Xia and Tully, 2007, Knox et al., 2003)
                                    Gq
                                    (Delmas et al., 2004)
                                    G?q
                                    (Pinal and Pichaud, 2007)
                                    GNAQ/11/14
                                    (Krishnan et al., 2015)
                                    Galpha
                                    (Ni et al., 2009)
                                    Galpha49B
                                    (Tsai et al., 2019, Ashwal-Fluss et al., 2014, Riveron et al., 2013, Sen et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Friedman et al., 2011, Tan et al., 2009, Hayden and Bosco, 2008, Haerty et al., 2007, Dorus et al., 2006, Dorus et al., 2006, Reiter et al., 2001)
                                    Galpha49b
                                    (Lum, 2003)
                                    Galphaq
                                    (Liu et al., 2022, Kline et al., 2017, Transgenic RNAi Project members, 2017-)
                                    Gaq
                                    (Liang et al., 2024, Brodskiy et al., 2019, Chorna and Hasan, 2012, Pinal and Pichaud, 2007, Elia et al., 2005, Hardie et al., 2002)
                                    Gq
                                    (Soundarrajan et al., 2021, Musselman and Kühnlein, 2018, Ogueta et al., 2018, Himmelreich et al., 2017, Jayakumar et al., 2016, Thakur et al., 2016, Wang et al., 2016, Chen et al., 2015, Tian et al., 2013, Boto et al., 2010, Kain et al., 2009, Boto et al., 2007, Kwon and Montell, 2006, Kain et al., 2005)
                                    Gqa-3
                                    (Zelhof et al., 2001)
                                    Gqalpha
                                    (Voolstra et al., 2015, Riveron et al., 2013)
                                    Gqα
                                    (Gutorov et al., 2022, Hodge et al., 2022, Balakrishnan et al., 2018, Katz and Minke, 2018, Katz et al., 2017, Leung and Montell, 2017, Yasin et al., 2017, Hanlon and Andrew, 2015, Pak et al., 2012, Rosenbaum et al., 2012, Bredendiek et al., 2011, Kain et al., 2010, Sanxaridis et al., 2007, Rosenbaum et al., 2006, Montell, 2005, Xu et al., 2004, Montell, 1999, Wes et al., 1999)
                                    Gqαe
                                    (Elia et al., 2005)
                                    Gqαe
                                    (Pinal and Pichaud, 2011)
                                    Gqα{e}
                                    (Elia et al., 2005)
                                    Gα
                                    (Yamashita et al., 2005, Lee and Montell, 2004, Zemelman et al., 2002, Tsunoda et al., 2001, Burack and Shaw, 2000)
                                    Gα49B
                                    (Al-Ramahi et al., 2018, Sokabe et al., 2016, Im et al., 2015, Shen et al., 2011, Kwon et al., 2008, McGurk et al., 2008, Meyer et al., 2008, Bakal et al., 2007, Landry et al., 2007, Dorus et al., 2006, Taraszka et al., 2005, Yang et al., 2005)
                                    Gα49b
                                    (Hanlon and Andrew, 2015)
                                    Gαq
                                    (Hu et al., 2012, Elsaesser et al., 2010, Yao and Carlson, 2010, Wang et al., 2008, Lee et al., 2004, Harris and Lim, 2001, Montell, 2000, Schulz et al., 1999)
                                    Gαq
                                    (Ahmad et al., 2025, Akai et al., 2025, Gujar and Wang, 2025, Berry et al., 2024, Hsu et al., 2024, Lockyer et al., 2024, Nolan et al., 2024, Yin et al., 2024, Davis, 2023, Khan et al., 2023, Križaj et al., 2023, Stevens et al., 2023, Sebastian et al., 2022, Bilder et al., 2021, Heier et al., 2021, Li et al., 2021, Liu et al., 2021, Morris and Jasper, 2021, Noyes et al., 2021, O'Connor et al., 2021, Soundarrajan et al., 2021, Yeates and Frank, 2021, Chvilicek et al., 2020, Gu et al., 2020, Karam et al., 2020, Raghuraman et al., 2020, Toprak et al., 2020, Voolstra and Huber, 2020, Aleyakpo et al., 2019, Cao et al., 2018, Herman et al., 2018, Hori et al., 2018, Kim et al., 2018, Himmelreich et al., 2017, Kamalesh et al., 2017, Bernardo-Garcia et al., 2016, Mishra et al., 2016, Wang et al., 2016, Yadav et al., 2016, Bennett et al., 2015, Brusich et al., 2015, El Chamy et al., 2015, Kim et al., 2015, Krishnan et al., 2015, Rister et al., 2015, Yamanaka et al., 2015, Buchon et al., 2013, Ferrandon, 2013, FlyBase Genome Annotators, 2013, Kuraishi et al., 2013, Rister et al., 2013, Vaqué et al., 2013, Chakrabarti et al., 2012, Deng et al., 2011, Elsaesser et al., 2010, Katanayeva et al., 2010, Voolstra et al., 2010, Buchon et al., 2009, Ha et al., 2009, Han et al., 2006, Hiramoto and Hiromi, 2006, Meyer et al., 2006, Banerjee and Hasan, 2005, Baumann, 2004, Hardie et al., 2004, Roman, 2004, Schillo et al., 2004, Hardie et al., 2003, Hardie et al., 2002, Suh et al., 2001, Agam et al., 2000, Cook et al., 2000, Chyb et al., 1999, Scott and Zuker, 1998, Scott et al., 1997)
                                    dGqα
                                    (Smith, 1996, Talluri et al., 1995)
                                    dGαq
                                    (Xia and Tully, 2006)
                                    dGaα
                                    (Kalidas and Smith, 2002)
                                    dGq
                                    (Zhang et al., 2013, Georgiev et al., 2005)
                                    dGqa-49b
                                    (Kalidas et al., 2001)
                                    dGqalpha-3
                                    (Talluri, 1995.7.5)
                                    dGqα
                                    (Kwon et al., 2010, Kwon et al., 2010, Kwon et al., 2008, Lee and Montell, 2004, Smith et al., 1995)
                                    dGqα-49b
                                    (Smith et al., 2001)
                                    dgq
                                    (Hanlon and Andrew, 2015, Pinal and Pichaud, 2011, Kain et al., 2010, Satoh et al., 2010, Kain et al., 2009, Kain et al., 2008, Pumir et al., 2008, Sanxaridis et al., 2007, Banerjee et al., 2006, Kain et al., 2005, Satoh and Ready, 2005, Cronin et al., 2004, Iakhine et al., 2002, Ratnaparkhi et al., 2002, Zemelman et al., 2002, Banerjee and Hasan, 2001, Hardie, 2001, Iakhine et al., 2001, Kiselev et al., 2000, Ratnaparkhi and Hasan, 1999, Wilkie, 1999, Milligan et al., 1997, Alvarez et al., 1996, Zars and Hyde, 1996, Zuker, 1996, Scott et al., 1995, Talluri et al., 1995, Zars and Hyde, 1995, Lee et al., 1994, Lee, 1993.3.10, Zuker, 1992, Ranganathan et al., 1991, Lee et al., 1990)
                                    dgqα
                                    (Buchner, 1991)
                                    gα49B
                                    (Hilgers et al., 2011)
                                    sast
                                    (Hu et al., 2012)
                                    Name Synonyms
                                    G protein 49B
                                    (Goldman and Arbeitman, 2007)
                                    G protein alpha subunit q
                                    (Hori et al., 2018)
                                    G protein alpha49B
                                    (Jaspers et al., 2012, Cammarato et al., 2011, Khanna et al., 2010)
                                    G protein α q subunit
                                    G protein α49B
                                    G-protein alpha49B
                                    (Hayden and Bosco, 2008)
                                    G-protein α subunit
                                    (Rosenbaum et al., 2014)
                                    G-protein-αq
                                    small amplify and slow termination
                                    (Hu et al., 2012)
                                    Secondary FlyBase IDs
                                    • FBgn0004178
                                    Datasets (0)
                                    Study focus (0)
                                    Experimental Role
                                    Project
                                    Project Type
                                    Title
                                    Study result (0)
                                    Result
                                    Result Type
                                    Title
                                    External Crossreferences and Linkouts ( 77 )
                                    Sequence Crossreferences
                                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                    UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                    Other crossreferences
                                    AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                    DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                    EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                    FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                    FlyMine - An integrated database for Drosophila genomics
                                    InterPro - A database of protein families, domains and functional sites
                                    KEGG Genes - Molecular building blocks of life in the genomic space.
                                    MARRVEL_MODEL - MARRVEL (model organism gene)
                                    Linkouts
                                    BioGRID - A database of protein and genetic interactions.
                                    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                    DroID - A comprehensive database of gene and protein interactions.
                                    DRSC - Results frm RNAi screens
                                    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                    Flygut - An atlas of the Drosophila adult midgut
                                    FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                                    KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                    MIST (genetic) - An integrated Molecular Interaction Database
                                    MIST (protein-protein) - An integrated Molecular Interaction Database
                                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                    Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
                                    References (313)