FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

G protein activity

ID (Ontology)

GO:0003925 (Gene Ontology)

Definition

A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP).[ PubMed:16923326 PubMed:24470015 ]

Also Known As

"signaling G protein activity"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Results list data from multiple species. Choose a record type above to open its HitList.

Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
G protein activity (all annotations which use CV term, excluding "NOT" statements)
enables \| G protein activity

Spanning Tree (Parents/Children)

molecular_function
 |__molecular function regulator activity_________
ribonucleoside triphosphate phosphatase activity  |
 |__GTPase activity_______________________________|
                                                  G protein activity  11 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	GTPase activity molecular function regulator activity
Part of
Synonyms & Secondary IDs
Synonyms
	"heterotrimeric G-protein GTPase activity" NARROW "large G-protein activity" NARROW "large G-protein GTPase activity" NARROW "Ras superfamily protein" NARROW "signaling G protein activity" EXACT "small G-protein" NARROW "small GTPase" NARROW "small GTPase activity" NARROW "small monomeric G protein activity" NARROW "small monomeric GTPase activity" NARROW
Secondary IDs

External Crossreferences & Linkouts
	EC:3.6.5.1 EC:3.6.5.2 Reactome:R-HSA-400027 "Gq alpha:G beta:G gamma dissociates to Gq alpha:GTP and G beta:G gamma" Reactome:R-HSA-422320 "Heterotrimeric G(s) complex dissociates"