Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
457 (aa); 53 (kD)
G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\cta using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\cta in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Variegation of lt and cta is manifest at phenotypic and gene expression levels in the adult eye, and the larval salivary glands and Malpighian tubules. The relative severity of the effect correlates with the chromosomal rearrangement. Larval imaginal discs do not display variegation, but show uniform reduction of transcription, which correlates in magnitude with the degree of variegation.
The cta locus displays reduced variation, the HKA test demonstrates that background selection is not the sole force for reducing variation. Reduction of variation does not extend to the ref(2)P locus.
Sequence analysis suggests that cta encodes an alpha subunit of a G protein. cta has a role in cell-cell communication as a mediator of signals between membrane bound receptors and intracellular effectors during gastrulation.
Mutations in cta block the transition from the first slow stochastic phase of gastrulation to the second rapid phase of constriction in the ventral furrow and the posterior midgut invaginations.
Maternal effect gene required for gastrulation.