Construct: Amino acid replacement: Q303R. Mutation of a cta cDNA, expression is driven a female germ line specific promoter.
Expression causes overall flattening of the embryo surface, disruption of the regular array of cells, interference with the cephalic furrow formation and non-responsiveness of mitotic cells.
ctaGerm.Q303R rescues cta5
Constitutive activation of cta.