FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
cta, ric8a
FlyBase ID
FBig0000099032
Interaction Network
Interactions Browser links
cta network
ric8a network
Reported Interactions
FBrf0223162-1.coIP.WB
Reference
Peters and Rogers, 2013
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
cta 

Cta

bait

Myc tag

cta 
cta 
ric8a 

Ric-8

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
cta 
region
mutation increasing interaction
aa 302

G302A, locked in inactive GDP-bound state

cta 
region
mutation decreasing interaction
aa 303

Q303L, locked in active GTP-bound state

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from endogenous gene.

(Peters and Rogers, 2013)

ric8a binds constitutively inactive cta more strongly.

(Peters and Rogers, 2013)
FBrf0223162-2.coIP.WB
Reference
Peters and Rogers, 2013
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
ric8a 

Ric-8

bait

GFP tag

ric8a 
ric8a 
cta 

Cta

prey

Myc tag

cta 
cta 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
cta 
region
mutation increasing interaction
aa 302

G302A, locked in inactive GDP-bound state

cta 
region
mutation decreasing interaction
aa 303

Q303L, locked in active GTP-bound state

ric8a 
region
mutation decreasing interaction
aa 71aa 75

R71E

R75E

ric8a 
region
mutation disrupting interaction
aa 414aa 434aa 484aa 485

R414E

E434K

D484K

T485A

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Peters and Rogers, 2013)

ric8a binds constitutively inactive cta more strongly.

(Peters and Rogers, 2013)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (1)