FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ctaGerm.R277C
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General Information
Symbol
Dmel\ctaGerm.R277C
Species
D. melanogaster
Name
FlyBase ID
FBal0086668
Feature type
allele
Associated gene
Dmel\cta
Associated Insertion(s)
Carried in Construct
P{ctaR277C}
Key Links
Transgenic product class
missense_variant
(Morize et al., 1998)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Morize et al., 1998)
Mutagen
in vitro construct
(Morize et al., 1998)
Progenitor genotype
Carried in construct
P{ctaR277C}
Cytology
Description

Construct: Amino acid replacement: R277C. Residue is located at the cholera toxin-sensitive site. Mutation of a cta cDNA, expression is driven a female germ line specific promoter.

(Morize et al., 1998)
Allele components
Component
Use(s)
Encoded product / tool
cta
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression causes overall flattening of the embryo surface, disruption of the regular array of cells, interference with the cephalic furrow formation and non-responsiveness of mitotic cells.

      (Morize et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      ctaGerm.R277C rescues cta5

      (Morize et al., 1998)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Constitutive activation of cta.

      (Morize et al., 1998)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ctaGOF
      (Morize et al., 1998)
      ctaGerm.R277C
      Name Synonyms
      Secondary FlyBase IDs
        References (1)