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Citation
Leung, N.Y., Thakur, D.P., Gurav, A.S., Kim, S.H., Di Pizio, A., Niv, M.Y., Montell, C. (2020). Functions of Opsins in Drosophila Taste.  Curr. Biol. 30(8): 1367--1379.e6.
FlyBase ID
FBrf0245471
Publication Type
Research paper
Abstract

Rhodopsin is a light receptor comprised of an opsin protein and a light-sensitive retinal chromophore. Despite more than a century of scrutiny, there is no evidence that opsins function in chemosensation. Here, we demonstrate that three Drosophila opsins, Rh1, Rh4, and Rh7, are needed in gustatory receptor neurons to sense a plant-derived bitter compound, aristolochic acid (ARI). The gustatory requirements for these opsins are light-independent and do not require retinal. The opsins enabled flies to detect lower concentrations of aristolochic acid by initiating an amplification cascade that includes a G-protein, phospholipase Cβ, and the TRP channel, TRPA1. In contrast, responses to higher levels of the bitter compound were mediated through direct activation of TRPA1. Our study reveals roles for opsins in chemosensation and raise questions concerning the original roles for these classical G-protein-coupled receptors.

PubMed ID
PubMed Central ID
PMC7252503 (PMC) (EuropePMC)
Related Publication(s)
Note

Sensory Neuroscience: A Taste for Light and the Origin of Animal Vision.
Pisani et al., 2020, Curr. Biol. 30(13): R773--RR775 [FBrf0248938]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Curr. Biol.
    Title
    Current Biology
    Publication Year
    1991-
    ISBN/ISSN
    0960-9822
    Data From Reference