FB2021_02, released April 13, 2021

Allele: Dmel\TrpA1UAS.C.cZa

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General Information
Symbol
Dmel\TrpA1UAS.C.cZa
Species
D. melanogaster
Name
FlyBase ID
FBal0267192
Feature type
allele
Associated gene
Dmel\TrpA1
Associated Insertion(s)
Carried in Construct
P{UAS-TrpA1-C.Z}
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
in vitro construct - regulatory fusion
(Zhong et al., 2012)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Carried in construct
      P{UAS-TrpA1-C.Z}
      Cytology
      Nature of the lesion
      Statement
      Reference

      UAS regulatory sequences drive expression of the "TRPA1-C" isoform (GenBank:JN400354) of TrpA1.

      (Zhong et al., 2012)
      Allele components
      Product class / Tool use(s)
      Regulatory region(s)
      UAS
      Encoded product / tool
      TrpA1
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      TrpA1UAS.C.cZa/Scer\GAL4ppk.1.9 rescues TrpA1W903

      (Zhong et al., 2012)
      Comments

      Expression of TrpA1Scer\UAS.C.cZa under the control of Scer\GAL4ppk.1.9 rescues the thermal nociception phenotypes seen in TrpA1W903/Df(3L)ED4415 mutant larvae. In addition, expression of TrpA1Scer\UAS.C.cZa does not lower the behavioural threshold for thermal nociception. The mechanical nociception phenotypes seen in TrpA1W903/Df(3L)ED4415 mutants are not rescued.

      (Zhong et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      TrpA1C.Scer\UAS
      TrpA1Scer\UAS.C.cZa
      TrpA1UAS.C.cZa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)