evolutionarily conserved modulator of the insulin/PI3K signaling pathway - mutants mimic the effects of nutrient deprivation producing adults with 40% less fat than normal - binds to Tsc1 and modulates TOR activity
Gene model reviewed during 5.46
None of the polypeptides share 100% sequence identity.
Interacts with TSC1 and FOXO.
The PH domain is required for membrane targeting.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\melt using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\melt in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Area matching Drosophila EST AA698011.
Candidate gene for quantitative trait (QTL) locus determining bristle number.