FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
sav, wts
FlyBase ID
FBig0000098881
Interaction Network
Interactions Browser links
sav network
wts network
Reported Interactions
FBrf0151717-1.PD.WB
Reference
Tapon et al., 2002
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
sav 

Sav

bait

GST tag

sav 
wts 

Wts

prey

Myc tag

wts 
wts 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
sav 
WW domain
sufficient binding region
aa 419-495
wts 
PPXY motif
sufficient binding region
GRQMLPPPPYQSNNN

this peptide blocks the interaction

wts 
PPXY motif
mutation disrupting interaction
aa 550

Y550A mutation renders GRQMLPPPPYQSNNN peptide unable to block the interaction

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; bait produced as a recombinant fusion protein in bacterial system; prey derived from transfected 293T cell extract.

(Tapon et al., 2002)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (1)