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Citation
Rauskolb, C., Sun, S., Sun, G., Pan, Y., Irvine, K.D. (2014). Cytoskeletal Tension Inhibits Hippo Signaling through an Ajuba-Warts Complex.  Cell 158(1): 143--156.
FlyBase ID
FBrf0225521
Publication Type
Research paper
Abstract

Mechanical forces have been proposed to modulate organ growth, but a molecular mechanism that links them to growth regulation in vivo has been lacking. We report that increasing tension within the cytoskeleton increases Drosophila wing growth, whereas decreasing cytoskeletal tension decreases wing growth. These changes in growth can be accounted for by changes in the activity of Yorkie, a transcription factor regulated by the Hippo pathway. The influence of myosin activity on Yorkie depends genetically on the Ajuba LIM protein Jub, a negative regulator of Warts within the Hippo pathway. We further show that Jub associates with α-catenin and that its localization to adherens junctions and association with α-catenin are promoted by cytoskeletal tension. Jub recruits Warts to junctions in a tension-dependent manner. Our observations delineate a mechanism that links cytoskeletal tension to regulation of Hippo pathway activity, providing a molecular understanding of how mechanical forces can modulate organ growth.

Graphical Abstract
Obtained with permission from Cell Press.
PubMed ID
PubMed Central ID
PMC4082802 (PMC) (EuropePMC)
Related Publication(s)
Note

Development. Mechanical forces linked to organ growth.
Baumann, 2014, Nat. Rev. Mol. Cell Biol. 15(8): 501 [FBrf0226350]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference