FlyBase Allele Report: Dmel\jub[GD7185]

General Information

Symbol

Dmel\jub^GD7185

Species

D. melanogaster

Name

FlyBase ID

FBal0261094

Feature type

allele

Associated gene

Dmel\jub

Associated Insertion(s)

Carried in Construct

P{GD7185}

Also Known As

UAS-RNAi-Jub, UAS-jub RNAi^GD

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Rauskolb et al., 2011)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Rauskolb et al., 2011)

Mutagen

in vitro construct

(Rauskolb et al., 2011)

Progenitor genotype

Carried in construct

P{GD7185}

Cytology

Description

UASt drives expression of an RNAi construct targeting jub.

(Rauskolb et al., 2011)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD7185

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size, with Scer\GAL4^nub-AC-62

(Rauskolb et al., 2011)

increased cell size | larval stage, with Scer\GAL4^hth-GETDB

(Ku and Sun, 2017)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

antennal disc | larval stage, with Scer\GAL4^hth-GETDB

(Ku and Sun, 2017)

wing, with Scer\GAL4^nub-AC-62

(Rauskolb et al., 2011)

Detailed Description

Statement

Reference

Expression of jub^GD7185 under the control of Scer\GAL4^hth-GETDB in larval antennal discs does not lead to any obvious defects in the formation of the A1 fold or segregation of cells with respect to the field boundary at the A1 fold, but mutant cells exhibit some morphological defects, such as swelling, enlargement, or delamination, as compared to controls.

(Ku and Sun, 2017)

Expression of jub^GD7185 (together with Dcr-2^Scer\UAS.cDa) using Scer\GAL4^nub-AC-62 reduces wing size.

(Rauskolb et al., 2011)

Expression under the control of Scer\GAL4^pnr-MD237 results in the absence of 0% or 0-10% of the Scer\GAL4^pnr-MD237-expressing area of the notum, depending on the insertion line used.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

7185

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^nub-AC-62, jub^GD7185 has abnormal size phenotype, enhanceable by Zyx^NIG.32018R/Scer\GAL4^nub-AC-62

(Rauskolb et al., 2011)

Enhancer of

Statement

Reference

Scer\GAL4^nub-AC-62/jub^GD7185 is an enhancer of abnormal size phenotype of Scer\GAL4^nub-AC-62, Zyx^NIG.32018R

(Rauskolb et al., 2011)

Suppressor of

Statement

Reference

Scer\GAL4^nub-AC-62/jub^GD7185 is a suppressor of abnormal size phenotype of Scer\GAL4^nub-AC-62, ft^GD881

(Rauskolb et al., 2011)

Scer\GAL4^nub-AC-62/jub^GD7185 is a suppressor of abnormal size phenotype of Scer\GAL4^nub-AC-62, ex^GD12782

(Rauskolb et al., 2011)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^nub-AC-62, jub^GD7185 has wing phenotype, enhanceable by Zyx^NIG.32018R/Scer\GAL4^nub-AC-62

(Rauskolb et al., 2011)

Enhancer of

Statement

Reference

Scer\GAL4^nub-AC-62/jub^GD7185 is an enhancer of wing phenotype of Scer\GAL4^nub-AC-62, Zyx^NIG.32018R

(Rauskolb et al., 2011)

Suppressor of

Statement

Reference

Scer\GAL4^nub-AC-62/jub^GD7185 is a suppressor of wing phenotype of Scer\GAL4^nub-AC-62, ft^GD881

(Rauskolb et al., 2011)

Scer\GAL4^nub-AC-62/jub^GD7185 is a suppressor of wing phenotype of Scer\GAL4^nub-AC-62, ex^GD12782

(Rauskolb et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of both jub^GD7185 and Zyx102EF^NIG.32018R (together with Dcr-2^Scer\UAS.cDa) using Scer\GAL4^nub-AC-62 induces a greater reduction in wing size than when either is expressed individually.

The wing overgrowth phenotype associated with Scer\GAL4^nub-AC-62-mediated expression of ft^GD881 (together with Dcr-2^Scer\UAS.cDa) is suppressed by co-expression of jub^GD7185.

The wing overgrowth phenotype associated with Scer\GAL4^nub-AC-62-mediated expression of ex^GD12782 (together with Dcr-2^Scer\UAS.cDa) is suppressed by co-expression of jub^GD7185.

(Rauskolb et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v38442

w¹¹¹⁸; P{GD7185}v38442

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

7185

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

jub^GD7185

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

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