FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\RokGD1522
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General Information
Symbol
Dmel\RokGD1522
Species
D. melanogaster
Name
FlyBase ID
FBal0210486
Feature type
allele
Associated gene
Dmel\Rok
Associated Insertion(s)
Carried in Construct
P{GD1522}
Also Known As
UAS-rok-RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
in vitro construct
(Dickson et al., 2007.7.18)
Progenitor genotype
Carried in construct
P{GD1522}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD1522
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  cancer
      modeled by RhoGEF2RE.UAS, RafUAS.F179
      (Khoo et al., 2013)
      exacerbates  carcinoma
      modeled by scrib1
      (Kong et al., 2022)
      ameliorates  Huntington's disease
      modeled by Hsap\HTT128Q.1-336.UAS
      (Al-Ramahi et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of RokGD1522 under the control of Scer\GAL4GMR.PU does not lead to significant changes in eye size, as compared to controls.

      (Llavero Hurtado et al., 2017)

      Expression of RokGD1522 under the control of Scer\GAL4Bx-MS1096 results in central wing blisters.

      (Bilousov et al., 2014)

      Eye-antennal disc clones expressing RokGD1522 under the control of Scer\GAL4tub.PU do not exhibit size difference or changes in photoreceptor differentiation as compared to wild type clones, although they do exhibit some minor cell morphology defects.

      (Khoo et al., 2013)

      Adults expressing RokGD1522 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

      (Neely et al., 2010)

      Expression under the control of Scer\GAL4pnr-MD237 results in planar polarity defects in the orientation of bristles of the notum in 40-50% of the Scer\GAL4pnr-MD237 expression domain.

      Expression under the control of Scer\GAL4pnr-MD237 results in an enlarged notum.

      (Mummery-Widmer et al., 2009)
      External Data
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The small eye induced by the expression of Cln3UAS.cTa under the control of Scer\GAL4GMR.PU is partially suppressed by the co-expression of RokGD1522.

      (Llavero Hurtado et al., 2017)

      Co-expression of RokGD1522 suppresses the small clone size, differentiation and cell morphology defects seen in eye-antennal disc clones expressing RhoGEF2RE.Scer\UAS under the control of Scer\GAL4tub.PU.

      Co-expression of RokGD1522 suppresses the formation of undifferentiated clonal masses and partially suppresses the reduction of differentiation seen in eye-antennal disc clones expressing both RhoGEF2RE.Scer\UAS and RafScer\UAS.F179 under the control of Scer\GAL4tub.PU, and also suppresses the developmental delay shown by larvae containing these clones.

      Co-expression of RokGD1522 fails to suppress the ectopic differentiation of seen in eye-antennal disc clones expressing RafScer\UAS.F179 under the control of Scer\GAL4tub.PU.

      (Khoo et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 1 )
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      RokGD1522
      rokGD1522
      (Al-Ramahi et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (20)