FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

ID (Ontology)

GO:0042771 (Gene Ontology)

Definition

The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (all annotations which use CV term, excluding "NOT" statements)
involved_in \| intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

Spanning Tree (Parents/Children)

DNA damage response
 |__intrinsic apoptotic signaling pathway in response to DNA damage__
signal transduction by p53 class mediator                            |
 |__intrinsic apoptotic signaling pathway by p53 class mediator______|
intrinsic apoptotic signaling pathway                                |
 |__intrinsic apoptotic signaling pathway in response to DNA damage__|
 |__intrinsic apoptotic signaling pathway by p53 class mediator______|
                                                                     intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  6 rec.
                                                                      |__regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3 rec.
                                                                          |__negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2 rec.
                                                                          |__positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 1 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway by p53 class mediator
Part of
Synonyms & Secondary IDs
Synonyms
	"DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED
Secondary IDs

External Crossreferences & Linkouts