FB2026_02 , released June 18, 2026
Allele: Dmel\exAP49
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General Information
Symbol
Dmel\exAP49
Species
D. melanogaster
Name
FlyBase ID
FBal0217809
Feature type
allele
Associated gene
Dmel\ex
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - genetic evidence

    (Hamaratoglu et al., 2006, Hamaratoglu et al., 2006)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: ?986term.

    (Hamaratoglu et al., 2006)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    2L:445,863..445,863 [+]
    Nucleotide change:

    C445863T

    Amino acid change:

    Q986term | ex-PA; Q986term | ex-PB

    Reported amino acid change:

    ?986term

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Hamaratoglu et al., 2006)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 1 )
        Disease
        Evidence
        References
        model of  cancer
        CEA
        (Hamaratoglu et al., 2006)
        Modifiers Based on Experimental Evidence ( 1 )
        Disease
        Interaction
        References
        model of  cancer
        is exacerbated by wtsx1
        (Hamaratoglu et al., 2006)
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        exAP49 homozygous mutant clones generated in the male germline develop normally. 16 cells are observed per cyst, and cell size and morphology are indistinguishable from neighbouring control cells. However, non-autonomous germline over-proliferation is observed in non-mutant spermatogonial cysts.

        (Sun et al., 2008)

        exAP49 homozygous late third instar larvae have moderately overgrown wing discs.

        (Hamaratoglu et al., 2006)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhanced by
        Statement
        Reference

        exAP49 has hyperplasia | recessive phenotype, enhanceable by wtsx1/wts[+]

        (Hamaratoglu et al., 2006)
        Phenotype Manifest In
        Enhanced by
        Statement
        Reference

        exAP49 has wing disc phenotype, enhanceable by wtsx1/wts[+]

        (Hamaratoglu et al., 2006)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Wing disc overgrowth seen in exAP49 homozygous late third instar larvae is enhanced by wtsx1/+.

        (Hamaratoglu et al., 2006)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        exAP49
        (Sun et al., 2008, Hamaratoglu et al., 2006)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)