FlyBase Allele Report: Dmel\wts[RNAi.UAS.cUa]

General Information

Symbol

Dmel\wts^RNAi.UAS.cUa

Species

D. melanogaster

Name

FlyBase ID

FBal0407724

Feature type

allele

Associated gene

Dmel\wts

Associated Insertion(s)

Carried in Construct

P{UAS-wts.RNAi.U}

Also Known As

wts-RNAi, UAS-wts^RNAi

Key Links

Transgenic product class

RNAi_reagent

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

(FlyBase Curators, 2025-)

Progenitor genotype

Carried in construct

P{UAS-wts.RNAi.U}

Cytology

Description

UAS regulatory sequences drive expression of a wts RNA line.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

wts

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of cancer

CEA

(Jang et al., 2017)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates cancer

modeled by scrib^GD11666

(Ding et al., 2021)

modeled by Tao^RNAi.UAS.cUa

(Jang et al., 2017)

model of cancer

is exacerbated by trio^UAS.cUa

(Jang et al., 2017)

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.UAS.cUa}

(Irwin et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage, with Scer\GAL4^GMR.long, Scer\GAL4^ey.PH

(Jukam et al., 2016)

abnormal size | larval stage, with Scer\GAL4^hh.PU

(Sansores-Garcia et al., 2011)

lethal - all die before end of larval stage, with Scer\GAL4^ptc.PU

(Li et al., 2024)

Phenotype Manifest In

photoreceptor cell R8 of yellow ommatidium, with Scer\GAL4^GMR.long, Scer\GAL4^ey.PH

(Jukam et al., 2016)

wing disc, with Scer\GAL4^hh.PU

(Sansores-Garcia et al., 2011)

wing disc posterior compartment, with Scer\GAL4^nub-AC-62

(Rauskolb et al., 2014)

Detailed Description

Statement

Reference

Expression of wts^VDRC.cUa under the control of Scer\GAL4^ey.PH and Scer\GAL4^GMR.long, in combination with a Dicer-2 transgene to enhance RNAi efficiency, causes a decrease in the number of yellow R8 photoreceptors, compared to controls.

(Jukam et al., 2016)

Expression of wts^VDRC.cUa under the control of Scer\GAL4^C587 has no apparent germarium phenotype.

(Li et al., 2015)

Expression of wts^VDRC.cUa under the control of Scer\GAL4^nub-AC-62 results in overgrowth of the posterior compartment of the wing disc.

(Rauskolb et al., 2014)

Expression of wts^{dsRNA.UAS.cUa} under the control of Scer\GAL4^hh.PU causes overgrowth of the expressing region of the wing disc in the larva.

(Sansores-Garcia et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

wts^RNAi.UAS.cUa/Scer\GAL4^C587 is a suppressor | partially of neoplasia | female | adult stage phenotype of Scer\GAL4^C587, ci^{RNAi.UASp.cLa}

(Li et al., 2015)

wts^RNAi.UAS.cUa/Scer\GAL4^C587 is a suppressor | partially of neoplasia | female | adult stage phenotype of Scer\GAL4^C587, ci^{RNAi.UASp.cLa}, hpo^UAS.cWa

(Li et al., 2015)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Scer\GAL4^nub-AC-62, wts^RNAi.UAS.cUa has wing disc posterior compartment phenotype, non-suppressible by Rok^RNAi.UAS.cUa, Scer\GAL4^nub-AC-62

(Rauskolb et al., 2014)

Suppressor of

Statement

Reference

wts^RNAi.UAS.cUa/Scer\GAL4^C587 is a suppressor | partially of germarium phenotype of Scer\GAL4^C587, ci^{RNAi.UASp.cLa}

(Li et al., 2015)

wts^RNAi.UAS.cUa/Scer\GAL4^C587 is a suppressor | partially of germarium phenotype of Scer\GAL4^C587, ci^{RNAi.UASp.cLa}, hpo^UAS.cWa

(Li et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The rather moderate tumorous germarium phenotype characteristic for adult female flies expressing ci^{dsRNA.shRNA.Scer\UAS.P\T} under the control of Scer\GAL4^C587 is significantly improved by co-expression of wts^VDRC.cUa. Co-expression of wts^VDRC.cUa can also partially rescue the aggravated tumorous phenotype of flies expressing both ci^{dsRNA.shRNA.Scer\UAS.P\T} and hpo^Scer\UAS.cWa simultaneously.

(Li et al., 2015)

Expression of Rok^VDRC.cUa does not suppress the wing disc posterior compartment overgrowth seen in flies expressing wts^VDRC.cUa under the control of Scer\GAL4^nub-AC-62.

(Rauskolb et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

wts^RNAi.UAS.cUa

wts^RNAi

(Chen et al., 2020)

wts^TRiP.cUa

wts^VDRC.cUa

wts^{dsRNA.Scer\UAS.cUa}

wts^{dsRNA.UAS.cUa}

Name Synonyms

Secondary FlyBase IDs

FBal0327033
FBal0360175
FBal0297465

References (15)

Report Sections

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