FlyBase Allele Report: Dmel\Rrp4[KK108526]

General Information

Symbol

Dmel\Rrp4^KK108526

Species

D. melanogaster

Name

FlyBase ID

FBal0235627

Feature type

allele

Associated gene

Dmel\Rrp4

Associated Insertion(s)

Carried in Construct

P{KK108526}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK108526}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK108526

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of short stature, hearing loss, retinitis pigmentosa, and distinctive facies

CEC

(Yang et al., 2020)

CEA

(Yang et al., 2020)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of short stature, hearing loss, retinitis pigmentosa, and distinctive facies

is ameliorated by Atg1^UAS.cSa

(Yang et al., 2020)

is ameliorated by Atg17^EY03045

(Yang et al., 2020)

is ameliorated by Hsap\EXOSC2^UAS.cYa

(Yang et al., 2020)

is ameliorated by Mitf^UAS.Tag:HA

(Yang et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response | adult stage, with Scer\GAL4^yolk

(Molleston et al., 2016)

decreased size | adult stage, with Scer\GAL4^ey.PU

(Yang et al., 2020)

lethal - all die before end of first instar larval stage, with Scer\GAL4^da.PU

(Yang et al., 2020)

partially lethal - majority die, with Scer\GAL4^ey.PU

(Yang et al., 2020)

visible | adult stage, with Scer\GAL4^ey.PU

(Yang et al., 2020)

Phenotype Manifest In

adult somatic muscle cell, with Scer\GAL4^Mhc.PU

(Yang et al., 2020)

eye, with Scer\GAL4^ey.PU

(Yang et al., 2020)

mitochondrion | adult stage, with Scer\GAL4^Mhc.PU

(Yang et al., 2020)

Detailed Description

Statement

Reference

Expressing Rrp4^KK108526 under the control of Scer\GAL4^ey.PU induces a rough and small eye, sometimes with small ectopic appendages.

Expression of Rrp4^KK108526 under the control of Scer\GAL4^Mhc.PU leads to mitochondria accumulation in adult muscles.

(Yang et al., 2020)

Expression of Rrp4^KK108526 under the control of Scer\GAL4^yolk and subsequent infection of adults with RVFV results in a significant increase in RVFV replication, but no difference in survival, as compared with control.

(Molleston et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Rrp4^KK108526, Scer\GAL4^ey.PU has increased mortality during development phenotype, enhanceable by Sox102F^HJF, Scer\GAL4^ey.PU

(Yang et al., 2020)

NOT Enhanced by

Statement

Reference

Rrp4^KK108526, Scer\GAL4^ey.PU has partially lethal - majority die phenotype, non-enhanceable by Sox102F^GD4589, Scer\GAL4^ey.PU

(Yang et al., 2020)

Rrp4^KK108526, Scer\GAL4^ey.PU has decreased size | adult stage phenotype, non-enhanceable by Sox102F^GD4589, Scer\GAL4^ey.PU

(Yang et al., 2020)

Rrp4^KK108526, Scer\GAL4^ey.PU has visible | adult stage phenotype, non-enhanceable by Sox102F^GD4589, Scer\GAL4^ey.PU

(Yang et al., 2020)

Rrp4^KK108526, Scer\GAL4^ey.PU has partially lethal - majority die phenotype, non-enhanceable by Atg1^UAS.cSa, Scer\GAL4^ey.PU

(Yang et al., 2020)

Suppressed by

Statement

Reference

Rrp4^KK108526, Scer\GAL4^ey.PU has increased mortality during development phenotype, suppressible | partially by Mitf^UAS.Tag:HA, Scer\GAL4^ey.PU

(Yang et al., 2020)

Rrp4^KK108526, Scer\GAL4^ey.PU has increased mortality during development phenotype, suppressible | partially by Atg17^EY03045, Scer\GAL4^ey.PU

(Yang et al., 2020)

Rrp4^KK108526, Scer\GAL4^ey.PU has decreased size | adult stage phenotype, suppressible | partially by Atg1^UAS.cSa, Scer\GAL4^ey.PU

(Yang et al., 2020)

Rrp4^KK108526, Scer\GAL4^ey.PU has decreased size | adult stage phenotype, suppressible | partially by Atg17^EY03045, Scer\GAL4^ey.PU

(Yang et al., 2020)

Rrp4^KK108526, Scer\GAL4^ey.PU has decreased size | adult stage phenotype, suppressible | partially by Mitf^UAS.Tag:HA, Scer\GAL4^ey.PU

(Yang et al., 2020)

Rrp4^KK108526, Scer\GAL4^ey.PU has visible | adult stage phenotype, suppressible | partially by Mitf^UAS.Tag:HA, Scer\GAL4^ey.PU

(Yang et al., 2020)

Rrp4^KK108526, Scer\GAL4^ey.PU has visible | adult stage phenotype, suppressible | partially by Atg1^UAS.cSa, Scer\GAL4^ey.PU

(Yang et al., 2020)

Rrp4^KK108526, Scer\GAL4^ey.PU has visible | adult stage phenotype, suppressible | partially by Atg17^EY03045, Scer\GAL4^ey.PU

(Yang et al., 2020)

Rrp4^KK108526, Scer\GAL4^ey.PU has decreased size | adult stage phenotype, suppressible | partially by Hsap\EXOSC2^UAS.cYa, Scer\GAL4^ey.PU

(Yang et al., 2020)

Rrp4^KK108526, Scer\GAL4^ey.PU has visible | adult stage phenotype, suppressible | partially by Hsap\EXOSC2^UAS.cYa, Scer\GAL4^ey.PU

(Yang et al., 2020)

NOT suppressed by

Statement

Reference

Rrp4^KK108526, Scer\GAL4^ey.PU has decreased size | adult stage phenotype, non-suppressible by Hsap\EXOSC2^G30V.UAS, Scer\GAL4^ey.PU

(Yang et al., 2020)

Rrp4^KK108526, Scer\GAL4^ey.PU has visible | adult stage phenotype, non-suppressible by Hsap\EXOSC2^G30V.UAS, Scer\GAL4^ey.PU

(Yang et al., 2020)

Rrp4^KK108526, Scer\GAL4^ey.PU has partially lethal - majority die phenotype, non-suppressible by Sox102F^GD4589, Scer\GAL4^ey.PU

(Yang et al., 2020)

Rrp4^KK108526, Scer\GAL4^ey.PU has decreased size | adult stage phenotype, non-suppressible by Sox102F^GD4589, Scer\GAL4^ey.PU

(Yang et al., 2020)

Rrp4^KK108526, Scer\GAL4^ey.PU has visible | adult stage phenotype, non-suppressible by Sox102F^GD4589, Scer\GAL4^ey.PU

(Yang et al., 2020)

Rrp4^KK108526, Scer\GAL4^ey.PU has partially lethal - majority die phenotype, non-suppressible by Atg1^UAS.cSa, Scer\GAL4^ey.PU

(Yang et al., 2020)

Other

Statement

Reference

Atg17^EY03045, Rrp4^KK108526, Scer\GAL4^ey.PU has partially lethal - majority die phenotype

(Yang et al., 2020)

Rrp4^KK108526, Scer\GAL4^ey.PU, Sox102F^HJF has lethal phenotype

(Yang et al., 2020)

Mitf^UAS.Tag:HA, Rrp4^KK108526, Scer\GAL4^ey.PU has partially lethal - majority die phenotype

(Yang et al., 2020)

Hsap\EXOSC2^G30V.UAS, Rrp4^KK108526, Scer\GAL4^ey.PU has visible | adult stage phenotype

(Yang et al., 2020)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Rrp4^KK108526, Scer\GAL4^ey.PU has eye phenotype, non-enhanceable by Sox102F^GD4589, Scer\GAL4^ey.PU

(Yang et al., 2020)

Suppressed by

Statement

Reference

Rrp4^KK108526, Scer\GAL4^ey.PU has eye phenotype, suppressible | partially by Atg17^EY03045, Scer\GAL4^ey.PU

(Yang et al., 2020)

Rrp4^KK108526, Scer\GAL4^ey.PU has eye phenotype, suppressible | partially by Atg1^UAS.cSa, Scer\GAL4^ey.PU

(Yang et al., 2020)

Rrp4^KK108526, Scer\GAL4^ey.PU has eye phenotype, suppressible | partially by Mitf^UAS.Tag:HA, Scer\GAL4^ey.PU

(Yang et al., 2020)

Rrp4^KK108526, Scer\GAL4^ey.PU has eye phenotype, suppressible | partially by Hsap\EXOSC2^UAS.cYa, Scer\GAL4^ey.PU

(Yang et al., 2020)

NOT suppressed by

Statement

Reference

Rrp4^KK108526, Scer\GAL4^ey.PU has eye phenotype, non-suppressible by Sox102F^GD4589, Scer\GAL4^ey.PU

(Yang et al., 2020)

Rrp4^KK108526, Scer\GAL4^ey.PU has eye phenotype, non-suppressible by Hsap\EXOSC2^G30V.UAS, Scer\GAL4^ey.PU

(Yang et al., 2020)

Other

Statement

Reference

Hsap\EXOSC2^G30V.UAS, Rrp4^KK108526, Scer\GAL4^ey.PU has eye phenotype

(Yang et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expressing Hsap\EXOSC2^G30V.UAS does not rescue the small eye phenotype induced by the expression of Rrp4^KK108526 under the control of Scer\GAL4^ey.PU, and even leads to a glossy eye phenotype.

(Yang et al., 2020)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v102375

P{KK108526}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Rrp4^KK108526

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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