FlyBase Gene Report: Dmel\Mondo

General Information

Symbol

Dmel\Mondo

Species

D. melanogaster

Name

Mondo

Annotation Symbol

CG18362

Feature Type

protein_coding_gene

FlyBase ID

FBgn0032940

Gene Model Status

Current

Stock Availability

22 publicly available

Gene Summary

Mondo (Mondo) encodes a basic helix-loop-helix-leucine zipper transcription factor involved in lipid and carbohydrate metabolism. Together with its binding partner encoded by bigmax, it controls sugar-dependent gene expression, including activation of genes involved in lipogenesis. Mondo mutants are intolerant to dietary sugars and have impaired muscle function. [Date last reviewed: 2018-10-11] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Mio, ChREBP, Mlx interactor

Key Links

Genomic Location

Cytogenetic map

39C1-39C2

Sequence location

2L:21,286,078..21,310,050 [-]

Recombination map

2-54

RefSeq locus

NT_033779 REGION:21286078..21310050

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

contributes_to DNA binding

inferred from sequence or structural similarity with MGI:MGI:1927999

(Cairo et al., 2001)

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from biological aspect of ancestor with PANTHER:PTN000761437

(GO Reference Genome Project, 2011-)

enables protein dimerization activity

inferred from electronic annotation with InterPro:IPR011598, InterPro:IPR036638

(InterPro Project Members, 2004-)

enables protein heterodimerization activity

inferred from sequence or structural similarity with MGI:MGI:1927999

(Cairo et al., 2001)

enables RNA polymerase II cis-regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN000761437

(GO Reference Genome Project, 2011-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in glucose homeostasis

inferred from mutant phenotype

(Ugrankar et al., 2015, Musselman et al., 2013)

involved_in response to sucrose

inferred from mutant phenotype

(Musselman et al., 2013)

involved_in triglyceride homeostasis

inferred from mutant phenotype

(Musselman et al., 2013)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in regulation of DNA-templated transcription

inferred from sequence or structural similarity with FLYBASE:Max; FB:FBgn0017578

(Peyrefitte et al., 2001)

involved_in regulation of transcription by RNA polymerase II

inferred from sequence or structural similarity with MGI:MGI:1927999

(Cairo et al., 2001)

inferred from biological aspect of ancestor with PANTHER:PTN000761437

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN001039502

(GO Reference Genome Project, 2011-)

part_of transcription regulator complex

inferred from sequence or structural similarity with MGI:MGI:1927999

(Cairo et al., 2001)

Gene Group (FlyBase)

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS -: Basic helix-loop-helix (bHLH) transcription factors are sequence-specific DNA-binding proteins that regulate transcription. They are characterized by a 60 amino acid region comprising a basic DNA binding domain followed by a HLH motif formed from two amphipathic α-helices connected by a loop. bHLH transcription factors form homo- and hetero-dimeric complexes, which bind to a E box consensus sequence. (Adapted from PMID:15186484).

Summary (Interactive Fly)

bHLH leucine zipper transcription factor - coordinates feeding behavior with nutrient availability - controls fat accumulation in fat body

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Mondo for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VID4)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Mondo-RA

FBtr0081525

NM_165367

3837

1119

Mondo-RB

FBtr0081524

NM_136261

4276

1119

Mondo-RE

FBtr0081527

NM_165368

3300

925

Mondo-RF

FBtr0301457

NM_001169561

4834

1119

Mondo-RG

FBtr0301458

NM_001169562

3928

1119

Mondo-RH

FBtr0301459

NM_001169563

4837

1119

Mondo-RI

FBtr0301460

NM_001169564

4349

1119

Mondo-RJ

FBtr0301461

NM_001169565

4276

1119

Mondo-RK

FBtr0301462

NM_001169566

3830

1119

Mondo-RL

FBtr0301463

NM_001169567

3832

1119

Mondo-RM

FBtr0301464

NM_001169568

4068

1119

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Mondo-PA

FBpp0081053

125.2

1119

7.60

FBpp0081052

125.2

1119

7.60

FBpp0081055

103.0

925

8.64

FBpp0290672

125.2

1119

7.60

FBpp0290673

125.2

1119

7.60

FBpp0290674

125.2

1119

7.60

FBpp0290675

125.2

1119

7.60

FBpp0290676

125.2

1119

7.60

FBpp0290677

125.2

1119

7.60

FBpp0290678

125.2

1119

7.60

FBpp0290679

125.2

1119

7.60

Q9VID4

NP_001163039

ACZ94325

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1119 aa isoforms: Mondo-PA, Mondo-PB, Mondo-PF, Mondo-PG, Mondo-PH, Mondo-PI, Mondo-PJ, Mondo-PK, Mondo-PL, Mondo-PM

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mondo using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.68

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

anterior endoderm anlage

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

amnioserosa

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

embryonic stage 10 -- 15

amnioserosa

(Peyrefitte et al., 2001)

embryonic stage 11 -- 12

organism | faint | ubiquitous

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

embryonic stage 13 -- 15

dorsal pharyngeal muscle primordium

(Peyrefitte et al., 2001)

embryonic stage 13 -- 16

amnioserosa

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

embryonic stage 16

embryonic/larval fat body

(Peyrefitte et al., 2001)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

Expression Deduced from Reporters

Reporter: PBac{768.FSVS-0}Mondo^CPTI003395

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain

Comment: expression throughout adult brain, higher in neuropil ( adult subesophageal ganglion, supraesophageal ganglion )

(Knowles-Barley, 2011.8.24)

adult gnathal ganglion

Comment: expression throughout adult brain, higher in neuropil ( adult subesophageal ganglion, supraesophageal ganglion )

(Knowles-Barley, 2011.8.24)

adult gnathal ganglion | restricted

Comment: part of adult subesophageal ganglion

(Knowles-Barley, 2011.8.24)

supraesophageal ganglion

Comment: expression throughout adult brain, higher in neuropil ( adult subesophageal ganglion, supraesophageal ganglion )

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Mondo in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Mondo

View exonic expression by tissue for Dmel\Mondo

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0032940

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35402/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0032940

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0032940

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0032940

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG18362

Flygut - An atlas of the Drosophila adult midgut

FBgn0032940

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Mondo

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 17 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 14 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Mondo

Transgenic constructs containing regulatory region of Mondo

Aberrations (Deficiencies and Duplications) ( 4 )

Inferred from experimentation ( 4 )

Gene disrupted in

Df(2L)crc^R2

(Hewes et al., 2000)

Df(2L)Rev4

(Hewes et al., 2003)

Gene partially disrupted in

Df(2L)crc^E98

(Hewes et al., 2000)

Gene not disrupted in

Df(2L)crc^R6

(Hewes et al., 2000)

Inferred from location ( 12 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

Mondo^YD1036

lethal - all die during larval stage | chemical conditional, with Scer\GAL4^Cg.PA

Mondo^RNAi.UAS.cUa

partially lethal | conditional, with Scer\GAL4^αTub84B.PL

Mondo^KK109174

viable

Mondo^EY00908

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Mondo^GD12723

viable, with Scer\GAL4^tin.CΔ4

Mondo^GD12723

Sterility

Allele

fertile

Mondo^EY00908

Other Phenotypes

Allele

abnormal developmental rate | conditional, with Scer\GAL4^αTub84B.PL

Mondo^KK109174

abnormal feeding behavior | adult stage, with Scer\GAL4^yolk

Mondo^RNAi.Sym.UAS

abnormal stress response | larval stage, with Scer\GAL4^Cg.PA

Mondo^RNAi.UAS.cUa

chemical sensitive | larval stage, with Scer\GAL4^Cg.PA

Mondo^RNAi.UAS.cUa

decreased body size | larval stage, with Scer\GAL4^Cg.PA

Mondo^RNAi.UAS.cUa

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (26)

Hsap\MLXIP

11 of 14

Yes

Hsap\MLXIPL

11 of 14

Yes

Hsap\ARNT2

1 of 14

Hsap\CCDC169-SOHLH2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (20)

Rnor\Mlxip

11 of 14

Yes

Rnor\Mlxipl

9 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (19)

Mmus\Mlxip

11 of 14

Yes

Mmus\Mlxipl

10 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (13)

Xtro\mlxip

8 of 13

Yes

Xtro\mlxipl

6 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (21)

Drer\mlxip

10 of 14

Yes

Drer\LOC100535945

7 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (6)

Cele\mml-1

9 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (7)

Agam\AgaP_AGAP009806

5 of 12

Yes

Agam\AgaP_AGAP009801

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (74)

Atha\AT1G10120

2 of 13

Yes

Atha\AT3G07340

2 of 13

Yes

Atha\AT4G16430

2 of 13

Yes

Atha\AT4G28815

2 of 13

Yes

Atha\AT4G37850

2 of 13

Yes

Atha\BIM2

2 of 13

Yes

Atha\BPEp

2 of 13

Yes

Atha\CIB5

2 of 13

Yes

Atha\FRU

2 of 13

Yes

Atha\GL3

2 of 13

Yes

Atha\HBI1

2 of 13

Yes

Atha\MYC2

2 of 13

Yes

Atha\MYC3

2 of 13

Yes

Atha\MYC4

2 of 13

Yes

Atha\NAI1

2 of 13

Yes

Atha\PIF3

2 of 13

Yes

Atha\PIL1

2 of 13

Yes

Atha\PIL5

2 of 13

Yes

Atha\UNE10

2 of 13

Yes

Atha\AIB

1 of 13

Atha\ALC

1 of 13

Yes

Atha\AMS

1 of 13

Yes

Atha\APTX

1 of 13

Atha\AT1G01260

1 of 13

Atha\AT1G03040

1 of 13

Yes

Atha\AT1G68920

1 of 13

Yes

Atha\AT2G14760

1 of 13

Yes

Atha\AT2G22750

1 of 13

Yes

Atha\AT2G22760

1 of 13

Atha\AT2G42300

1 of 13

Yes

Atha\AT2G43140

1 of 13

Yes

Atha\AT3G21330

1 of 13

Yes

Atha\AT3G23690

1 of 13

Yes

Atha\AT4G00870

1 of 13

Yes

Atha\AT4G28790

1 of 13

Yes

Atha\AT4G28800

1 of 13

Yes

Atha\AT4G28811

1 of 13

Yes

Atha\AT4G29930

1 of 13

Yes

Atha\AT5G43175

1 of 13

Yes

Atha\AT5G48560

1 of 13

Yes

Atha\AT5G50915

1 of 13

Yes

Atha\AT5G56960

1 of 13

Atha\AT5G57150

1 of 13

Yes

Atha\AT5G62610

1 of 13

Yes

Atha\BEE1

1 of 13

Yes

Atha\BEE2

1 of 13

Yes

Atha\BEE3

1 of 13

Yes

Atha\BIM1

1 of 13

Yes

Atha\CES

1 of 13

Yes

Atha\CIB1

1 of 13

Yes

Atha\EGL3

1 of 13

Atha\FBH1

1 of 13

Yes

Atha\FBH2

1 of 13

Yes

Atha\FBH3

1 of 13

Yes

Atha\FBH4

1 of 13

Yes

Atha\HFR1

1 of 13

Yes

Atha\ICE1

1 of 13

Yes

Atha\IND

1 of 13

Yes

Atha\LRL1

1 of 13

Yes

Atha\LRL2

1 of 13

Yes

Atha\LRL3

1 of 13

Yes

Atha\NIG1

1 of 13

Yes

Atha\PIF4

1 of 13

Yes

Atha\PIF7

1 of 13

Yes

Atha\PIL2

1 of 13

Atha\PIL6

1 of 13

Atha\RGE1

1 of 13

Yes

Atha\RHD6

1 of 13

Yes

Atha\RSL1

1 of 13

Yes

Atha\RSL2

1 of 13

Yes

Atha\RSL4

1 of 13

Yes

Atha\SCRM2

1 of 13

Yes

Atha\SPT

1 of 13

Yes

Atha\UNE12

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\CBF1

1 of 13

Yes

Scer\INO4

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\SPAC3F10.12c

1 of 12

Yes

Spom\sre2

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Mondo. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (7)

bigmax

4 of 13

crp

3 of 13

Max

1 of 13

Mitf

1 of 13

Myc

1 of 13

SREBP

1 of 13

twi

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

Mondo^JF02400

model of alcohol use disorder

CEA

(O'Farrell et al., 2023)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

MLXIP; MLX interacting protein

11 of 14

608090

MLXIPL; MLX interacting protein like

11 of 14

605678

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

Mondo - B52

systematic evolution of ligands by exponential enrichment, full identification by DNA sequencing, electrophoretic mobility shift assay, autoradiography

(Kim et al., 2003)

protein-protein

Physical Interaction

Assay

References

Mondo - Hr78

two hybrid array

(Shokri et al., 2019)

Mondo - Pdp1

two hybrid array

(Shokri et al., 2019)

Mondo - Rel

two hybrid array

(Shokri et al., 2019)

Mondo - bigmax

anti tag coimmunoprecipitation, western blot

(Havula et al., 2013)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Ar1|Ar2

suppressible

Mondo

(Sano et al., 2022)

Sord1|Sord2

suppressible

Mondo

(Sano et al., 2022)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

61352

DroID - A comprehensive database of gene and protein interactions.

FBgn0032940

MIST (protein-protein) - An integrated Molecular Interaction Database

35402

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

PKA-mediated phosphorylation of key metabolic factors

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

PKA-mediated phosphorylation of key metabolic factors

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-54

Cytogenetic map

39C1-39C2

Sequence location

2L:21,286,078..21,310,050 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

39C1-39C2

Limits computationally determined from genome sequence between P{lacW}l(2)k14505^k14505&P{lacW}l(2)k05106^k05106 and P{PZ}l(2)05095a^05095a

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-54

(FlyBase, 2016)

2-54.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (22)

Genomic Clones (25)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (79)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

FI20159

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0032940

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0032940

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Source for identity of Mio CG18362 was sequence identity ( date:011221 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: Mio CG18362

(FlyBase, 1996-)

Source for identity of: Mondo Mio

(FlyBase, 2009-)

Nomenclature comments

Renamed from 'Mio' to 'Mondo' (a synonym, and the symbol first used for the Drosophila gene in FBrf0149636) to minimise confusion with the 'mio' ('missing oocyte') gene symbol, from which it differed only by case.

(FlyBase, 2009-)

Etymology

Synonyms and Secondary IDs (15)

Reported As

Symbol Synonym

154826_at

(Kristensen et al., 2005)

CG18362

(Delamotte et al., 2025, National Institute of Genetics Fly Stocks, 2022-, Kim et al., 2015, Musselman et al., 2013, Schertel et al., 2013, Keleman et al., 2009.8.5, Perkins et al., 2009.3.31, Stevens et al., 2008, Stevens et al., 2008, Quinones-Coello, 2007, Quinones-Coello, 2007, Hewes et al., 2003, Ledent and Vervoort, 2001, Peyrefitte et al., 2001)

ChREBP

(Hemba-Waduge et al., 2025, Ugrankar et al., 2018, Kim et al., 2015)

Mio

(Kitatani et al., 2020, Trinh et al., 2019, Ugrankar et al., 2018, Chng et al., 2017, Whon et al., 2017, Alfa and Kim, 2016, Brookheart and Duncan, 2016, Ugrankar et al., 2015, Musselman et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Sassu et al., 2012, Alic et al., 2011, Ren et al., 2011, Quinones-Coello, 2007, Quinones-Coello, 2007, Cairo et al., 2001)

Mondo-Mlx

(Koyama et al., 2020)

anon-39Da

bHLHd12

(Stevens et al., 2008)

dmondo

(Billin et al., 2000)

gene Y

(Hewes et al., 2000)

mio

(Schertel et al., 2013)

mlx

(Bartok et al., 2015)

mondo

(O'Farrell et al., 2023, Bartok et al., 2015)

Name Synonyms

Mlx interactor

(Whon et al., 2017)

Mondo

(Mattila and Hietakangas, 2017, Bartok et al., 2015, Matsuda et al., 2015)

WBSCR14-related

(Cairo et al., 2001)

Secondary FlyBase IDs

FBgn0041170

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 85 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35402

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VID4

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VID4

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0032940

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35402/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0032940

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0032940

FlyMine - An integrated database for Drosophila genomics

FBgn0032940

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG18362

MARRVEL_MODEL - MARRVEL (model organism gene)

35402

Linkouts

BioGRID - A database of protein and genetic interactions.

61352

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0032940

DroID - A comprehensive database of gene and protein interactions.

FBgn0032940

DRSC - Results frm RNAi screens

FBgn0032940

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0032940

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0032940

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG18362

Flygut - An atlas of the Drosophila adult midgut

FBgn0032940

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0032940

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC034695

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

35402

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

PKA-mediated phosphorylation of key metabolic factors

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

PKA-mediated phosphorylation of key metabolic factors

References (102)

The following external sites may use different assemblies or annotations than FlyBase.

-1.68

Report Sections