FB2026_02 , released June 18, 2026
Allele: Dmel\MondoRNAi.Sym.UAS
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General Information
Symbol
Dmel\MondoRNAi.Sym.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0277859
Feature type
allele
Associated gene
Dmel\Mondo
Associated Insertion(s)
Carried in Construct
P{UAS-Mondo.RNAi.Sym}
Key Links
Transgenic product class
RNAi_reagent
(Sassu et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Sassu et al., 2012)
Mutagen
in vitro construct
(Sassu et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-Mondo.RNAi.Sym}
Cytology
Description

UAS regulatory sequences drive expression of a dsRNA corresponding to positions 1772-2679 of Mondo-RB.

(Sassu et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Mondo
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of MiodsRNA.Sym.Scer\UAS under the control of Scer\GAL4Cg.PA significantly decreases total triglyceride levels in wandering third instar larvae compared to controls.

      Expression of MiodsRNA.Sym.Scer\UAS under the control of Scer\GAL4yolk significantly decreases total triglyceride levels in adult females compared to controls. This appears to be due to a change in the amount of fat per cell rather than changing fat cell number.

      Adults expressing MiodsRNA.Sym.Scer\UAS under the control of Scer\GAL4yolk show reduced food consumption compared to controls. These flies show normal starvation-induced sleep deprivation and the total bout number and average bout length of sleep is comparable to wild type under both fed and starvation conditions.

      Expression of MiodsRNA.Sym.Scer\UAS under the control of Scer\GAL4to.PD significantly decreases total triglyceride levels in adult males compared to controls.

      (Sassu et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      MiodsRNA.Sym.Scer\UAS
      MondoRNAi.Sym.UAS
      MondodsRNA.Sym.Scer\UAS
      MondodsRNA.Sym.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)