FlyBase Gene Report: Dmel\bigmax

General Information

Symbol

Dmel\bigmax

Species

D. melanogaster

Name

bigmax

Annotation Symbol

CG3350

Feature Type

protein_coding_gene

FlyBase ID

FBgn0039509

Gene Model Status

Current

Stock Availability

13 publicly available

Gene Summary

bigmax (bigmax) encodes a basic helix-loop-helix-leucine zipper transcription factor. Together with its binding partner encoded by Mondo, the product of bigmax is involved in sugar-dependent gene regulation. It is involved in transcriptional control of many metabolic pathways, including glycolysis, de novo lipogenesis and the pentose phosphate pathway. Loss of bigmax function produces dietary sugar intolerance. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

mlx

Key Links

Genomic Location

Cytogenetic map

97F1-97F1

Sequence location

3R:27,287,366..27,288,526 [-]

Recombination map

3-93

RefSeq locus

NT_033777 REGION:27287366..27288526

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from biological aspect of ancestor with PANTHER:PTN000761437

(GO Reference Genome Project, 2011-)

enables protein dimerization activity

inferred from electronic annotation with InterPro:IPR011598, InterPro:IPR036638

(InterPro Project Members, 2004-)

enables RNA polymerase II cis-regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN000761437

(GO Reference Genome Project, 2011-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in adult feeding behavior

inferred from mutant phenotype

(Sassu et al., 2012)

involved_in positive regulation of transcription by RNA polymerase II

inferred from mutant phenotype

(Teesalu et al., 2017)

involved_in response to glucose

inferred from mutant phenotype

(Teesalu et al., 2017)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in regulation of DNA-templated transcription

inferred from sequence or structural similarity with FLYBASE:Max; FB:FBgn0017578

(Peyrefitte et al., 2001)

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN000761437

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN001039502

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS -: Basic helix-loop-helix (bHLH) transcription factors are sequence-specific DNA-binding proteins that regulate transcription. They are characterized by a 60 amino acid region comprising a basic DNA binding domain followed by a HLH motif formed from two amphipathic α-helices connected by a loop. bHLH transcription factors form homo- and hetero-dimeric complexes, which bind to a E box consensus sequence. (Adapted from PMID:15186484).

Summary (Interactive Fly)

bHLH transcription factor - binding partner of Mondo a nutrient sensor that functions in the fat body - regulates fatty acid synthesis - facilitates use of sugar-rich nutrient sources - regulates transcription factor Cabut, coordinating energy metabolism

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\bigmax for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VB47)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

bigmax-RA

FBtr0085173

NM_143299

954

254

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

bigmax-PA

FBpp0084543

29.0

254

5.38

Q9VB47

NP_651556

AAF56696

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\bigmax using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

bigmax_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.79

Transcript Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

organism | ubiquitous

Comment: )

(Peyrefitte et al., 2001)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\bigmax in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\bigmax

View exonic expression by tissue for Dmel\bigmax

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0039509

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43293/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039509

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039509

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039509

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3350

Flygut - An atlas of the Drosophila adult midgut

FBgn0039509

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 13 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of bigmax

Transgenic constructs containing regulatory region of bigmax

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | conditional

bigmax¹

partially lethal, with Scer\GAL4^αTub84B.PL

bigmax^KK108056

partially lethal - majority die

bigmax¹

viable

bigmax^d07258

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

bigmax^GD4277

viable, with Scer\GAL4^pnr-MD237

bigmax^GD4277

viable, with Scer\GAL4^tin.CΔ4

bigmax^GD4277

Sterility

Allele

fertile

bigmax^d07258

Other Phenotypes

Allele

abnormal developmental rate

bigmax¹

abnormal developmental rate, with Scer\GAL4^αTub84B.PL

bigmax^KK108056

abnormal developmental rate | conditional

bigmax¹

increased occurrence of cell division | adult stage, with Scer\GAL4^NP0001

bigmax^NIG.3350R

majority die during pharate adult stage

bigmax¹

visible, with Scer\GAL4^Mef2.PR

bigmax^GD4277

Phenotype manifest in

Allele

adult midgut, with Scer\GAL4^NP0001

bigmax^NIG.3350R

wing, with Scer\GAL4^Mef2.PR

bigmax^GD4277

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (52)

Hsap\MLX

14 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (32)

Rnor\Mlx

14 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mus musculus (laboratory mouse) (33)

Mmus\Mlx

13 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (35)

Xtro\mlx

7 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\neurod4

1 of 13

Yes

Xtro\neurod6

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (37)

Drer\mlx

13 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (12)

Cele\mxl-2

9 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (18)

Agam\AgaP_AGAP000682

12 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP013301

1 of 12

Agam\AgaP_AGAP013335

1 of 12

Arabidopsis thaliana (thale-cress) (74)

Atha\AT1G10120

3 of 13

Yes

Atha\PIL1

3 of 13

Yes

Atha\AIB

2 of 13

Yes

Atha\AT1G01260

2 of 13

Yes

Atha\AT2G22760

2 of 13

Yes

Atha\AT3G07340

2 of 13

Yes

Atha\AT4G16430

2 of 13

Yes

Atha\AT4G28815

2 of 13

Yes

Atha\AT4G37850

2 of 13

Yes

Atha\AT5G56960

2 of 13

Yes

Atha\BIM2

2 of 13

Yes

Atha\BPEp

2 of 13

Yes

Atha\CIB5

2 of 13

Yes

Atha\EGL3

2 of 13

Yes

Atha\FRU

2 of 13

Yes

Atha\GL3

2 of 13

Yes

Atha\HBI1

2 of 13

Yes

Atha\MYC2

2 of 13

Yes

Atha\MYC3

2 of 13

Yes

Atha\MYC4

2 of 13

Yes

Atha\NAI1

2 of 13

Yes

Atha\PIF3

2 of 13

Yes

Atha\PIL2

2 of 13

Yes

Atha\PIL5

2 of 13

Yes

Atha\PIL6

2 of 13

Yes

Atha\UNE10

2 of 13

Yes

Atha\ALC

1 of 13

Yes

Atha\AMS

1 of 13

Yes

Atha\APTX

1 of 13

Atha\AT1G03040

1 of 13

Yes

Atha\AT1G05805

1 of 13

Yes

Atha\AT1G68920

1 of 13

Yes

Atha\AT2G14760

1 of 13

Yes

Atha\AT2G22750

1 of 13

Yes

Atha\AT2G42300

1 of 13

Yes

Atha\AT2G43140

1 of 13

Yes

Atha\AT3G21330

1 of 13

Yes

Atha\AT3G23690

1 of 13

Yes

Atha\AT4G00870

1 of 13

Yes

Atha\AT4G28790

1 of 13

Yes

Atha\AT4G28800

1 of 13

Yes

Atha\AT4G28811

1 of 13

Yes

Atha\AT4G29930

1 of 13

Yes

Atha\AT5G43175

1 of 13

Yes

Atha\AT5G48560

1 of 13

Yes

Atha\AT5G50915

1 of 13

Yes

Atha\AT5G57150

1 of 13

Yes

Atha\AT5G62610

1 of 13

Yes

Atha\BEE1

1 of 13

Yes

Atha\BEE2

1 of 13

Yes

Atha\BEE3

1 of 13

Yes

Atha\BIM1

1 of 13

Yes

Atha\CES

1 of 13

Yes

Atha\CIB1

1 of 13

Yes

Atha\FBH1

1 of 13

Yes

Atha\FBH2

1 of 13

Yes

Atha\FBH3

1 of 13

Yes

Atha\FBH4

1 of 13

Yes

Atha\HFR1

1 of 13

Yes

Atha\ICE1

1 of 13

Yes

Atha\IND

1 of 13

Yes

Atha\LRL1

1 of 13

Yes

Atha\LRL2

1 of 13

Yes

Atha\LRL3

1 of 13

Yes

Atha\NIG1

1 of 13

Yes

Atha\PIF4

1 of 13

Yes

Atha\PIF7

1 of 13

Yes

Atha\RHD6

1 of 13

Yes

Atha\RSL1

1 of 13

Yes

Atha\RSL2

1 of 13

Yes

Atha\RSL4

1 of 13

Yes

Atha\SCRM2

1 of 13

Yes

Atha\SPT

1 of 13

Yes

Atha\UNE12

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\CBF1

1 of 13

Yes

Scer\RTG3

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (4)

Spom\SPAC3F10.12c

2 of 12

Yes

Spom\esc1

1 of 12

Spom\sre1

1 of 12

Spom\sre2

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:bigmax. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (19)

Mondo

4 of 13

crp

3 of 13

ato

1 of 13

cato

1 of 13

cwo

1 of 13

Fer2

1 of 13

Fer3

1 of 13

Hand

1 of 13

Hey

1 of 13

HLH3B

1 of 13

HLH4C

1 of 13

Max

1 of 13

Mnt

1 of 13

Myc

1 of 13

net

1 of 13

sage

1 of 13

SREBP

1 of 13

tap

1 of 13

twi

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

MLX; MAX dimerization protein MLX

14 of 14

602976

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

bigmax - Mondo

anti tag coimmunoprecipitation, western blot

(Havula et al., 2013)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

bigmax

suppressible

Aldh-III

(Havula et al., 2013)

bigmax

suppressible

Pepck1

(Bartok et al., 2015)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

68179

DroID - A comprehensive database of gene and protein interactions.

FBgn0039509

MIST (protein-protein) - An integrated Molecular Interaction Database

43293

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-93

Cytogenetic map

97F1-97F1

Sequence location

3R:27,287,366..27,288,526 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

97F1-97F1

Limits computationally determined from genome sequence between P{PZ}sda⁰³⁸⁸⁴ and P{PZ}btz^rL203

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-93

(FlyBase, 2016)

3-90.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (13)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

19268

w¹¹¹⁸; P{XP}bigmax^d07258

29325

y¹ v¹; P{TRiP.JF02487}attP2

42559

y¹ v¹; P{TRiP.HMJ02215}attP40

66448

y¹ w^*; P{bigmax-GFP.FPTB}attP40

35463

y¹ sc^* v¹ sev²¹; P{TRiP.GL00389}attP2

80209

y¹ sc^* v¹ sev²¹; P{TOE.GS02566}attP40

3350R-1

3350R-3

v110630

v11259

w¹¹¹⁸; P{GD4277}v11259/CyO

v341444

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00511}attP40/CyO-GFP

v341915

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD01175}attP40/CyO-GFP

More stocks available...

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (21)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GM14426

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0039509

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0039509

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Havula et al., 2013)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA has been made from templates generated with primers directed against this gene. RNAi of bigmax results in dorsal overextension of primary dendrites and a reduction in lateral branching. RNAi also causes defects in muscle and defects in dendrite morphogenesis.

(Parrish et al., 2006)

Relationship to Other Genes

Source for database merge of

Additional comments

Source for identity of bigmax CG3350 was sequence comparison ( date:001220 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: bigmax CG3350

(FlyBase, 1996-)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

BIGMAX

(Reymond, 1999.12.9)

Bigmax

(Parra-Peralbo et al., 2021, Toprak et al., 2020, Mattila and Hietakangas, 2017, Alic et al., 2011, Deng et al., 2009, Parrish et al., 2006)

CG3350

(Delamotte et al., 2025, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Stevens et al., 2008, Stevens et al., 2008, Gorski et al., 2003, Ledent and Vervoort, 2001, Peyrefitte et al., 2001)

DmMlx

(Peyrefitte et al., 2001)

Mlx

(Hudry et al., 2019, Chng et al., 2017, Chng et al., 2017, Teesalu et al., 2017, Matsuda et al., 2015, Havula et al., 2013)

bHLHd13

(Stevens et al., 2008)

bigmax

(De Groef et al., 2024, Petrosky et al., 2024, Deshpande et al., 2022, Jia et al., 2022, Bonfini et al., 2021, Cho et al., 2020, Muñoz-Soriano et al., 2018, Transgenic RNAi Project members, 2017-, Baëza et al., 2015, Ugrankar et al., 2015, Japanese National Institute of Genetics, 2012.5.21, Malone et al., 2012, Sassu et al., 2012, Zhou et al., 2012, Blanco et al., 2010, Kong et al., 2010)

cg3350

(Havula et al., 2013)

mlx

(Cadena Del Castillo et al., 2025, Melvin et al., 2018, Mattila and Hietakangas, 2017, Bartok et al., 2015, Mattila et al., 2015, Havula et al., 2013)

Name Synonyms

Bigmax

(Manh et al., 2005)

Max-like protein X

(Mattila and Hietakangas, 2017)

big max

(Berger et al., 2012)

bigmax

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 37 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43293

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VB47

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VB47

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0039509

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43293/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039509

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039509

FlyMine - An integrated database for Drosophila genomics

FBgn0039509

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG3350

MARRVEL_MODEL - MARRVEL (model organism gene)

43293

Linkouts

BioGRID - A database of protein and genetic interactions.

68179

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0039509

DroID - A comprehensive database of gene and protein interactions.

FBgn0039509

DRSC - Results frm RNAi screens

FBgn0039509

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

bigmax_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039509

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0039509

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3350

Flygut - An atlas of the Drosophila adult midgut

FBgn0039509

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0039509

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC000954

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

43293

References (78)

The following external sites may use different assemblies or annotations than FlyBase.

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