FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\tap
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General Information
Symbol
Dmel\tap
Species
D. melanogaster
Name
target of Poxn
Annotation Symbol
CG7659
Feature Type
protein_coding_gene
FlyBase ID
FBgn0015550
Gene Model Status
Current
Stock Availability
11 publicly available
Gene Summary
May play a role in the specification of the sugar-sensitive adult gustatory neuron and affect the response to sugar and salt. Regulated by POXN. (UniProt, O16867)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

biparous, bps

Key Links
Genomic Location
Cytogenetic map
74A5-74A5
Sequence location
Recombination map
3-45
RefSeq locus
NT_037436 REGION:17359682..17361811
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from direct assay
(Liu et al., 2024)
enables E-box binding
inferred from direct assay
(Liu et al., 2024)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN001060907
(GO Reference Genome Project, 2011-)
enables E-box binding
inferred from biological aspect of ancestor with PANTHER:PTN000446010
(GO Reference Genome Project, 2011-)
enables protein dimerization activity
inferred from electronic annotation with InterPro:IPR011598, InterPro:IPR036638
(InterPro Project Members, 2004-)
Biological Process (8 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
involved_in axon guidance
inferred from mutant phenotype
(Yuan et al., 2016)
involved_in molting cycle, chitin-based cuticle
inferred from mutant phenotype
(Liu et al., 2024)
involved_in mushroom body development
inferred from mutant phenotype
(Yuan et al., 2016)
involved_in negative regulation of axon extension involved in axon guidance
inferred from mutant phenotype
(Yuan et al., 2016)
involved_in positive regulation of transcription by RNA polymerase II
inferred from direct assay
(Liu et al., 2024)
involved_in pupation
inferred from mutant phenotype
(Liu et al., 2024)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in axon development
inferred from biological aspect of ancestor with PANTHER:PTN000446010
(GO Reference Genome Project, 2011-)
involved_in positive regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000446010
(GO Reference Genome Project, 2011-)
involved_in sensory organ development
traceable author statement
(Skaer et al., 2002)
inferred from biological aspect of ancestor with PANTHER:PTN000446010
(GO Reference Genome Project, 2011-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Gautier et al., 1997)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000446010
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS -
Basic helix-loop-helix (bHLH) transcription factors are sequence-specific DNA-binding proteins that regulate transcription. They are characterized by a 60 amino acid region comprising a basic DNA binding domain followed by a HLH motif formed from two amphipathic α-helices connected by a loop. bHLH transcription factors form homo- and hetero-dimeric complexes, which bind to a E box consensus sequence. (Adapted from PMID:15186484).
Protein Function (UniProtKB)
May play a role in the specification of the sugar-sensitive adult gustatory neuron and affect the response to sugar and salt. Regulated by POXN.
(UniProt, O16867)
Summary (Interactive Fly)

bHLH transcription factor - Neurogenin/NeuroD homolog - a neural differentiation gene, acting later in the hierarchy of gene activation than the proneural genes - functionally interacts with the Wnt-PCP pathway to regulate neuronal extension and guidance.

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\tap for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry O16867)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.45

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
tap-RA
FBtr0075216
NM_079400
2130
398
Additional Transcript Data and Comments
Reported size (kB)

1.392 (longest cDNA)

(Gautier et al., 1997)

2.106 (compiled cDNA)

(Bush et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
tap-PA
FBpp0074978
44.9
398
7.01
O16867
NP_524124
AAF49352
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

398 (aa)

(Gautier et al., 1997)

407 (aa)

(Bush et al., 1996)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\tap using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.27

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
presumptive embryonic/larval nervous system | restricted
(Gautier et al., 1997)
presumptive embryonic/larval peripheral nervous system | restricted
(Gautier et al., 1997)
embryonic stage 4 -- 6
anlage in statu nascendi
(Fisher et al., 2012)
central brain anlage in statu nascendi
(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 9 -- 12
midline primordium | subset
(Kearney et al., 2004)
embryonic stage 10 -- 11
neuroblast NB4-1
(Bush et al., 1996)
embryonic stage 10 -- 15
larval ventral nerve cord | restricted
(Bush et al., 1996)
embryonic stage 11
neuroblast
(Bush et al., 1996)
embryonic ganglion mother cell
(Bush et al., 1996)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
midline primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
larval nervous system
(Fisher et al., 2012)
sensory nervous system primordium
(Fisher et al., 2012)
ventral midline of embryo
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
lineage MNB primary interneuron
(Kearney et al., 2004)
larval MP1 neuron
(Kearney et al., 2004)
Additional Descriptive Data

tap is expressed in two clusters of cells in each segment, one dorsal and one ventral that also express Poxn. In contrast to Poxn, it is expressed only at or near the onset of differentiation. The expression is very transient, lasting less than an hour. While Poxn is expressed in most or all of the progeny of a sensory mother cell, tap is expressed in only one cell of each organ. The expression of tap is dependent on Poxn.

(Gautier et al., 1997)

tap transcripts are first observed at stage 10 by in situ hybridization. At that time they are present in 5 cells per segment, one unpaired cell on the midline thought to be the median neuroblast and two pairs lateral to the midline one of which is probably neuroblast 4-1. During germ band extension, there is a large burst of tap expression in the ganglion mother cell (gmc) layer of the ventral nerve cord. An estimated 12-18 cells per hemisegment express tap in the gmc layer. After this, expression is restricted to progressively fe er cells. By stage 14, expression is found in cells at the lateral edge of the CNS. By stage 15, expression is maintained in two large cells per hemisegment. The sites of tap expression do not appear to overlap with elav or repo expression indicating that tap is not expressed in post-mitotic neurons or glia. Some tap-positive cells are synthesizing DNA, suggesting that they are progenitor cells of either neurons or glia.

(Bush et al., 1996)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
v'es2 neuron
(Gautier et al., 1997)
Additional Descriptive Data

Based on a series of double labelling experiments, the site of expression of tap protein in the chemosensory lineage was determined to be the anterior v'es2 neuron.

(Gautier et al., 1997)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Gautier et al., 1997)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\tap in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of tap
Transgenic constructs containing regulatory region of tap
Aberrations (Deficiencies and Duplications) ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | recessive
lethal - all die before end of larval stage
lethal - all die before end of larval stage, with Scer\GAL4phtm.PO
partially lethal - majority die, with Scer\GAL4phtm.PO
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal developmental rate, with Scer\GAL4phtm.PO
abnormal developmental rate, with Scer\GAL4spok.1.45
abnormal neuroanatomy | adult stage, with Scer\GAL4Mef2.247
abnormal neuroanatomy | adult stage, with Scer\GAL4tap-Gal4
abnormal neuroanatomy | adult stage | dominant
abnormal neuroanatomy | adult stage | somatic clone
abnormal neuroanatomy | P-stage | dominant
abnormal tarsal response | heat sensitive
decreased size | larval stage, with Scer\GAL4phtm.PO
decreased size | larval stage, with Scer\GAL4spok.1.45
increased mortality, with Scer\GAL4spok.1.45
majority die during embryonic stage
short lived | heat sensitive, with Scer\GAL4tin.CΔ4
some die during larval stage, with Scer\GAL4phtm.PO
some die during P-stage, with Scer\GAL4spok.1.45
visible, with Scer\GAL4Bx-MS1096
Phenotype manifest in
Allele
adult mushroom body alpha-lobe | adult stage
adult mushroom body alpha-lobe | adult stage, with Scer\GAL4tap-Gal4
adult mushroom body beta-lobe | adult stage
adult mushroom body beta-lobe | adult stage, with Scer\GAL4Mef2.247
adult mushroom body beta-lobe | adult stage, with Scer\GAL4tap-Gal4
adult mushroom body beta-lobe | adult stage | somatic clone
adult mushroom body beta-lobe | P-stage
axon | adult stage
axon | adult stage, with Scer\GAL4tap-Gal4
axon | adult stage | somatic clone
axon | P-stage
nucleus | decreased number | larval stage, with Scer\GAL4phtm.PO
prothoracic gland | larval stage, with Scer\GAL4phtm.PO
prothoracic gland | larval stage, with Scer\GAL4spok.1.45
wing, with Scer\GAL4Bx-MS1096
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (55)
Hsap\NEUROG1
8 of 14
Yes
Yes
2  
Hsap\NEUROG2
8 of 14
Yes
Yes
Hsap\NEUROG3
8 of 14
Yes
Yes
1  
Hsap\OLIG1
4 of 14
No
Yes
Hsap\OLIG2
4 of 14
No
Yes
Hsap\OLIG3
4 of 14
No
Yes
Hsap\BHLHA15
3 of 14
No
No
1  
Hsap\BHLHE22
3 of 14
No
No
2  
Hsap\BHLHE23
3 of 14
No
No
1  
Hsap\NEUROD1
3 of 14
No
Yes
Hsap\NEUROD2
3 of 14
No
Yes
Hsap\NEUROD6
3 of 14
No
Yes
Hsap\ATOH1
2 of 14
No
No
2  
Hsap\ATOH7
2 of 14
No
No
Hsap\ATOH8
2 of 14
No
No
Hsap\NEUROD4
2 of 14
No
Yes
Hsap\ASCL1
1 of 14
No
No
2  
Hsap\ASCL2
1 of 14
No
No
Hsap\ASCL3
1 of 14
No
No
Hsap\ASCL4
1 of 14
No
No
1  
Hsap\ASCL5
1 of 14
No
No
Hsap\BHLHA9
1 of 14
No
No
Hsap\FERD3L
1 of 14
No
No
1  
Hsap\FIGLA
1 of 14
No
No
Hsap\HAND1
1 of 14
No
No
Hsap\HAND2
1 of 14
No
No
1  
Hsap\ID1
1 of 14
No
No
Hsap\ID2
1 of 14
No
No
1  
Hsap\ID3
1 of 14
No
No
Hsap\ID4
1 of 14
No
No
Hsap\LYL1
1 of 14
No
No
Hsap\MESP1
1 of 14
No
No
Hsap\MESP2
1 of 14
No
No
Hsap\MSC
1 of 14
No
No
Hsap\MSGN1
1 of 14
No
No
Hsap\MYC
1 of 14
No
No
6  
Hsap\MYCL
1 of 14
No
No
Hsap\MYCN
1 of 14
No
No
Hsap\MYF5
1 of 14
No
No
Hsap\MYF6
1 of 14
No
No
1  
Hsap\MYOD1
1 of 14
No
No
Hsap\MYOG
1 of 14
No
No
1  
Hsap\NHLH1
1 of 14
No
No
Hsap\NHLH2
1 of 14
No
No
1  
Hsap\PTF1A
1 of 14
No
No
Hsap\SCX
1 of 14
No
No
Hsap\TAL1
1 of 14
No
No
1  
Hsap\TAL2
1 of 14
No
No
1  
Hsap\TCF15
1 of 14
No
No
Hsap\TCF21
1 of 14
No
No
Hsap\TCF23
1 of 14
No
No
Hsap\TCF24
1 of 14
No
No
Hsap\TFAP4
1 of 14
No
No
Hsap\TWIST1
1 of 14
No
No
1  
Hsap\TWIST2
1 of 14
No
No
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (52)
Rnor\Neurog1
8 of 14
Yes
Yes
Rnor\Neurog2
8 of 14
Yes
Yes
Rnor\Neurog3
8 of 14
Yes
Yes
Rnor\Olig1
4 of 14
No
Yes
Rnor\Olig2
4 of 14
No
Yes
Rnor\Olig3
4 of 14
No
Yes
Rnor\Bhlha15
3 of 14
No
No
Rnor\Bhlhe22
3 of 14
No
No
Rnor\Bhlhe23
3 of 14
No
No
Rnor\Neurod1
3 of 14
No
Yes
Rnor\Neurod4
3 of 14
No
Yes
Rnor\Neurod6
3 of 14
No
Yes
Rnor\Atoh1
2 of 14
No
No
Rnor\Atoh7
2 of 14
No
No
Rnor\Atoh8
2 of 14
No
No
Rnor\Ascl1
1 of 14
No
No
Rnor\Ascl2
1 of 14
No
No
Rnor\Ascl4
1 of 14
No
No
Rnor\Ascl5
1 of 14
No
No
Rnor\Bhlha9
1 of 14
No
No
Rnor\Ferd3l
1 of 14
No
No
Rnor\Figla
1 of 14
No
No
Rnor\Hand1
1 of 14
No
No
Rnor\Hand2
1 of 14
No
No
Rnor\Id1
1 of 14
No
No
Rnor\Id2
1 of 14
No
No
Rnor\Id3
1 of 14
No
No
Rnor\Id4
1 of 14
No
No
Rnor\Lyl1
1 of 14
No
No
Rnor\Mesp1
1 of 14
No
No
Rnor\Mesp2
1 of 14
No
No
Rnor\Msc
1 of 14
No
No
Rnor\Msgn1
1 of 14
No
No
Rnor\Mycn
1 of 14
No
No
Rnor\Mycs
1 of 14
No
No
Rnor\Myf5
1 of 14
No
No
Rnor\Myf6
1 of 14
No
No
Rnor\Myod1
1 of 14
No
No
Rnor\Myog
1 of 14
No
No
Rnor\Neurod2
1 of 14
No
Yes
Rnor\Nhlh1
1 of 14
No
No
Rnor\Ptf1a
1 of 14
No
No
Rnor\Scx
1 of 14
No
No
Rnor\Tal1
1 of 14
No
No
Rnor\Tal2
1 of 14
No
No
Rnor\Tcf15
1 of 14
No
No
Rnor\Tcf21
1 of 14
No
No
Rnor\Tcf23
1 of 14
No
No
Rnor\Tcf24
1 of 14
No
No
Rnor\Tfap4
1 of 14
No
No
Rnor\Twist1
1 of 14
No
No
Rnor\Twist2
1 of 14
No
No
Mus musculus (laboratory mouse) (53)
Mmus\Neurog1
8 of 14
Yes
Yes
3  
Mmus\Neurog2
8 of 14
Yes
Yes
1  
Mmus\Neurog3
8 of 14
Yes
Yes
Mmus\Olig1
4 of 14
No
Yes
Mmus\Olig2
4 of 14
No
Yes
Mmus\Olig3
4 of 14
No
Yes
Mmus\Bhlha15
3 of 14
No
No
Mmus\Bhlhe22
3 of 14
No
No
Mmus\Bhlhe23
3 of 14
No
No
Mmus\Neurod1
3 of 14
No
Yes
Mmus\Neurod2
3 of 14
No
Yes
Mmus\Neurod4
3 of 14
No
Yes
1  
Mmus\Neurod6
3 of 14
No
Yes
Mmus\Atoh1
2 of 14
No
No
6  
Mmus\Atoh7
2 of 14
No
No
4  
Mmus\Atoh8
2 of 14
No
No
Mmus\Ascl1
1 of 14
No
No
Mmus\Ascl2
1 of 14
No
No
Mmus\Ascl3
1 of 14
No
No
Mmus\Ascl4
1 of 14
No
No
Mmus\Ascl5
1 of 14
No
No
Mmus\Bhlha9
1 of 14
No
No
Mmus\Ferd3l
1 of 14
No
No
Mmus\Figla
1 of 14
No
No
Mmus\Hand1
1 of 14
No
No
Mmus\Hand2
1 of 14
No
No
Mmus\Id1
1 of 14
No
No
Mmus\Id2
1 of 14
No
No
Mmus\Id3
1 of 14
No
No
Mmus\Id4
1 of 14
No
No
Mmus\Lyl1
1 of 14
No
No
Mmus\Mesp1
1 of 14
No
No
Mmus\Mesp2
1 of 14
No
No
Mmus\Msc
1 of 14
No
No
Mmus\Msgn1
1 of 14
No
No
Mmus\Mycn
1 of 14
No
No
Mmus\Myf5
1 of 14
No
No
Mmus\Myf6
1 of 14
No
No
Mmus\Myod1
1 of 14
No
No
Mmus\Myog
1 of 14
No
No
Mmus\Nhlh1
1 of 14
No
No
Mmus\Ptf1a
1 of 14
No
No
Mmus\Scx
1 of 14
No
No
Mmus\Srebf2
1 of 14
No
No
Mmus\Tal1
1 of 14
No
No
Mmus\Tal2
1 of 14
No
No
Mmus\Tcf15
1 of 14
No
No
Mmus\Tcf21
1 of 14
No
No
Mmus\Tcf23
1 of 14
No
No
Mmus\Tcf24
1 of 14
No
No
Mmus\Tfap4
1 of 14
No
No
Mmus\Twist1
1 of 14
No
No
Mmus\Twist2
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (38)
Xtro\neurog1
6 of 13
Yes
Yes
Xtro\neurog2
6 of 13
Yes
Yes
Xtro\neurog3
6 of 13
Yes
Yes
Xtro\bhlha15
2 of 13
No
No
Xtro\olig3
2 of 13
No
Yes
Xtro\olig4
2 of 13
No
Yes
Xtro\ascl1
1 of 13
No
No
Xtro\atmin
1 of 13
No
No
Xtro\atoh1
1 of 13
No
No
Xtro\atoh7
1 of 13
No
No
Xtro\atoh8
1 of 13
No
No
Xtro\bhlhe22
1 of 13
No
No
Xtro\figla
1 of 13
No
No
Xtro\hand2
1 of 13
No
No
Xtro\id2
1 of 13
No
No
Xtro\id3
1 of 13
No
No
Xtro\id4
1 of 13
No
No
Xtro\ilrun
1 of 13
No
No
Xtro\LOC100489188
1 of 13
No
No
Xtro\LOC100493338
1 of 13
No
No
Xtro\LOC101732842
1 of 13
No
No
Xtro\med29
1 of 13
No
No
Xtro\mespa
1 of 13
No
No
Xtro\mespb
1 of 13
No
No
Xtro\msgn1
1 of 13
No
No
Xtro\mycl
1 of 13
No
No
Xtro\myf6
1 of 13
No
No
Xtro\neurod1
1 of 13
No
Yes
Xtro\neurod4
1 of 13
No
Yes
Xtro\neurod6
1 of 13
No
Yes
Xtro\pnpo
1 of 13
No
No
Xtro\ptf1a
1 of 13
No
No
Xtro\tal1
1 of 13
No
No
Xtro\tcf21
1 of 13
No
No
Xtro\tcf24
1 of 13
No
No
Xtro\tfap4
1 of 13
No
No
Xtro\twist1
1 of 13
No
No
Xtro\ube2e2
1 of 13
No
No
Danio rerio (Zebrafish) (60)
Drer\neurog1
8 of 14
Yes
Yes
Drer\neurog3
8 of 14
Yes
Yes
Drer\olig1
4 of 14
No
Yes
Drer\olig2
4 of 14
No
Yes
Drer\olig4
4 of 14
No
Yes
Drer\bhlha15
3 of 14
No
No
Drer\bhlhe23
3 of 14
No
No
Drer\neurod1
3 of 14
No
Yes
Drer\neurod2
3 of 14
No
Yes
Drer\neurod4
3 of 14
No
Yes
Drer\neurod6a
3 of 14
No
Yes
Drer\neurod6b
3 of 14
No
Yes
Drer\olig3
3 of 14
No
Yes
Drer\si:ch211-196c10.13
3 of 14
No
No
Drer\atoh1a
2 of 14
No
No
Drer\atoh1b
2 of 14
No
No
Drer\atoh1c
2 of 14
No
No
Drer\atoh7
2 of 14
No
No
Drer\atoh8
2 of 14
No
No
Drer\bhlhe22
2 of 14
No
No
Drer\ascl1a
1 of 14
No
No
Drer\ascl1b
1 of 14
No
No
Drer\bhlha9
1 of 14
No
No
Drer\ferd3l
1 of 14
No
No
Drer\figla
1 of 14
No
No
Drer\hand2
1 of 14
No
No
Drer\id1
1 of 14
No
No
Drer\id2a
1 of 14
No
No
Drer\id2b
1 of 14
No
No
Drer\id3
1 of 14
No
No
Drer\id4
1 of 14
No
No
Drer\LOC110440056
1 of 14
No
No
Drer\lyl1
1 of 14
No
No
Drer\mespaa
1 of 14
No
No
Drer\mespab
1 of 14
No
No
Drer\mespba
1 of 14
No
No
Drer\mespbb
1 of 14
No
No
Drer\mlxip
1 of 14
No
No
Drer\msc
1 of 14
No
No
Drer\msgn1
1 of 14
No
No
Drer\myf5
1 of 14
No
No
Drer\myf6
1 of 14
No
No
Drer\myod1
1 of 14
No
No
Drer\myog
1 of 14
No
No
Drer\nhlh2
1 of 14
No
No
Drer\ptf1a
1 of 14
No
No
Drer\scxa
1 of 14
No
No
Drer\scxb
1 of 14
No
No
Drer\si:ch211-246m6.4
1 of 14
No
No
Drer\tal1
1 of 14
No
No
Drer\tal2
1 of 14
No
No
Drer\tcf12
1 of 14
No
No
Drer\tcf15
1 of 14
No
No
Drer\tcf21
1 of 14
No
No
Drer\tcf23
1 of 14
No
No
Drer\tfap4
1 of 14
No
No
Drer\twist1a
1 of 14
No
No
Drer\twist1b
1 of 14
No
No
Drer\twist2
1 of 14
No
No
Drer\twist3
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (22)
Cele\ngn-1
8 of 14
Yes
Yes
Cele\hlh-16
3 of 14
No
Yes
Cele\cnd-1
2 of 14
No
Yes
Cele\hlh-17
2 of 14
No
No
Cele\hlh-31
2 of 14
No
No
Cele\hlh-32
2 of 14
No
No
Cele\hlh-1
1 of 14
No
No
Cele\hlh-3
1 of 14
No
No
Cele\hlh-4
1 of 14
No
No
Cele\hlh-6
1 of 14
No
No
Cele\hlh-8
1 of 14
No
No
Cele\hlh-10
1 of 14
No
No
Cele\hlh-11
1 of 14
No
No
Cele\hlh-12
1 of 14
No
No
Cele\hlh-13
1 of 14
No
No
Cele\hlh-14
1 of 14
No
No
Cele\hlh-15
1 of 14
No
No
Cele\hlh-19
1 of 14
No
No
Cele\hlh-30
1 of 14
No
No
Cele\hnd-1
1 of 14
No
No
Cele\lin-32
1 of 14
No
No
Cele\Y7A9D.1
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (24)
Agam\AgaP_AGAP005930
9 of 12
Yes
Yes
Agam\AgaP_AGAP007241
2 of 12
No
No
Agam\AgaP_AGAP009227
2 of 12
No
No
Agam\AgaP_AGAP009983
2 of 12
No
No
Agam\AgaP_AGAP013335
2 of 12
No
No
Agam\AgaP_AGAP000076
1 of 12
No
No
Agam\AgaP_AGAP000876
1 of 12
No
No
Agam\AgaP_AGAP000878
1 of 12
No
No
Agam\AgaP_AGAP001448
1 of 12
No
No
Agam\AgaP_AGAP001740
1 of 12
No
No
Agam\AgaP_AGAP001741
1 of 12
No
No
Agam\AgaP_AGAP003739
1 of 12
No
No
Agam\AgaP_AGAP003756
1 of 12
No
No
Agam\AgaP_AGAP003876
1 of 12
No
No
Agam\AgaP_AGAP004299
1 of 12
No
No
Agam\AgaP_AGAP004386
1 of 12
No
No
Agam\AgaP_AGAP004907
1 of 12
No
No
Agam\AgaP_AGAP007124
1 of 12
No
No
Agam\AgaP_AGAP007696
1 of 12
No
No
Agam\AgaP_AGAP007822
1 of 12
No
No
Agam\AgaP_AGAP007824
1 of 12
No
No
Agam\AgaP_AGAP007944
1 of 12
No
No
Agam\AgaP_AGAP011985
1 of 12
No
No
Agam\AgaP_AGAP013406
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (1)
Atha\UNE10
1 of 13
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:tap. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (26)
dimm
4 of 13
net
4 of 13
Oli
4 of 13
amos
3 of 13
ato
3 of 13
cato
2 of 13
sage
2 of 13
tx
2 of 13
ac
1 of 13
bigmax
1 of 13
crp
1 of 13
da
1 of 13
emc
1 of 13
Fer1
1 of 13
Fer2
1 of 13
Fer3
1 of 13
Hand
1 of 13
HLH3B
1 of 13
HLH4C
1 of 13
HLH54F
1 of 13
l(1)sc
1 of 13
Mnt
1 of 13
nau
1 of 13
sc
1 of 13
soul
1 of 13
twi
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 4 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    NEUROG1; neurogenin 1
    8 of 14
    601726
       
      NEUROG2; neurogenin 2
      8 of 14
      606624
          NEUROG3; neurogenin 3
          8 of 14
          604882
           
          OLIG1; oligodendrocyte transcription factor 1
          4 of 14
          606385
              OLIG2; oligodendrocyte transcription factor 2
              4 of 14
              606386
                  OLIG3; oligodendrocyte transcription factor 3
                  4 of 14
                  609323
                      BHLHA15; basic helix-loop-helix family member a15
                      3 of 14
                      608606
                           
                          BHLHE22; basic helix-loop-helix family member e22
                          3 of 14
                          613483
                               
                              BHLHE23; basic helix-loop-helix family member e23
                              3 of 14
                              609331
                                   
                                  NEUROD1; neuronal differentiation 1
                                  3 of 14
                                  601724
                                  NEUROD2; neuronal differentiation 2
                                  3 of 14
                                  601725
                                  NEUROD6; neuronal differentiation 6
                                  3 of 14
                                  611513
                                      Functional Complementation Data
                                      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                      Interactions
                                      Summary of Physical Interactions
                                      Summary of Genetic Interactions
                                      Interaction Browsers
                                      View in FlyBase Interactions Browser   View in MIST tool (external link)
                                      Please look at the allele data for full details of the genetic interactions
                                      Starting gene(s)
                                      Interaction type
                                      Interacting gene(s)
                                      Reference
                                      tap
                                      enhanceable
                                      dsh
                                      (Yuan et al., 2016)
                                      tap
                                      suppressible
                                      pdm3|Cpr49Ah
                                      (Liu et al., 2024)
                                      Starting gene(s)
                                      Interaction type
                                      Interacting gene(s)
                                      Reference
                                      Nab2
                                      suppressible
                                      tap
                                      (Lee et al., 2020)
                                      External Data
                                      Linkouts
                                      BioGRID - A database of protein and genetic interactions.
                                      DroID - A comprehensive database of gene and protein interactions.
                                      MIST (protein-protein) - An integrated Molecular Interaction Database
                                      Pathways
                                      Signaling Pathways (FlyBase)
                                      Metabolic Pathways
                                      FlyBase
                                      External Links
                                      External Data
                                      Linkouts
                                      Class of Gene
                                      Genomic Location and Detailed Mapping Data
                                      Chromosome (arm)
                                      3L
                                      Recombination map
                                      3-45
                                      Cytogenetic map
                                      74A5-74A5
                                      Sequence location
                                      FlyBase Computed Cytological Location
                                      Cytogenetic map
                                      Evidence for location
                                      74A5-74A5
                                      Limits computationally determined from genome sequence between P{PZ}Baldspot02281 and P{PZ}blot01658
                                      Experimentally Determined Cytological Location
                                      Cytogenetic map
                                      Notes
                                      References
                                      74B1-74B5
                                      (Ledent, 1996.2.16)
                                      74A-74A
                                      (Bush, 1997.9.5)
                                      74B-74B
                                      (determined by in situ hybridisation)
                                      (Gautier et al., 1997)
                                      74B1-74B2
                                      (determined by in situ hybridisation)
                                      (Perrimon et al., 1996)
                                      73D1-73D2
                                      (determined by in situ hybridisation) 74B1--2 (determined by in situ hybridisation)
                                      (BDGP Project Members, 1994-1999)
                                      Experimentally Determined Recombination Data
                                      Location

                                      3-45

                                      (FlyBase, 2016)

                                      3-40.6

                                      (Comeron et al., 2012)
                                      Left of (cM)
                                      Right of (cM)
                                      Notes
                                      Stocks and Reagents
                                      Stocks (11)
                                      Genomic Clones (20)
                                      cDNA Clones (76)
                                       

                                      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                      cDNA clones, fully sequenced
                                      BDGP DGC clones
                                      Other clones
                                        Drosophila Genomics Resource Center cDNA clones

                                        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                        cDNA Clones, End Sequenced (ESTs)
                                        BDGP DGC clones
                                        Other clones
                                        RNAi and Array Information
                                        Linkouts
                                        DRSC - Results frm RNAi screens
                                        Antibody Information
                                        Laboratory Generated Antibodies
                                         

                                        monoclonal

                                        (Gautier et al., 1997)
                                        Commercially Available Antibodies
                                         
                                        Cell Line Information
                                        Publicly Available Cell Lines
                                         
                                          Other Stable Cell Lines
                                           
                                            Other Comments

                                            tap is expressed in a small subset of neurons when they undergo differentiation. In the peripheral nervous system, tap is expressed exclusively in one of the neurons that innervates each larval chemosensory organ, possibly controlling the specific properties of that neuron. Expression of tap is regulated by Poxn.

                                            (Gautier et al., 1997)

                                            tap is expressed in both neuronal and glial precursors after they have progressed beyond the ectodermal vs neuronal decision but before they differentiate into mature neurons or glia. Unlike other neural bHLH genes, expression persists until very late stages of embryogenesis.

                                            (Bush et al., 1996)

                                            The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation. tap gene expression during oogenesis is not critical to embryonic development, but the gene function may be essential for fertilisation and/or completion of meiosis.

                                            (Perrimon et al., 1996)

                                            The expression of tap, which encodes a basic HLH protein, is dependent on Poxn.

                                            (Ledent et al., 1995)
                                            Relationship to Other Genes
                                            Source for database merge of

                                            Source for merge of: tap bps

                                            (Dambly-Chaudiere and Vervoort, 1998)

                                            Source for merge of: tap bps l(3)01658

                                            (Ledent et al., 1998)
                                            Additional comments
                                            Nomenclature History
                                            Source for database identify of
                                            Nomenclature comments
                                            Etymology

                                            'biparous' means producing two offspring, based on its expression in progenitor cells that give rise to two types of cells.

                                            (Bush et al., 1996)
                                            Synonyms and Secondary IDs (11)
                                            Datasets (0)
                                            Study focus (0)
                                            Experimental Role
                                            Project
                                            Project Type
                                            Title
                                            Study result (0)
                                            Result
                                            Result Type
                                            Title
                                            External Crossreferences and Linkouts ( 36 )
                                            Sequence Crossreferences
                                            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                            Other crossreferences
                                            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                            FlyMine - An integrated database for Drosophila genomics
                                            InterPro - A database of protein families, domains and functional sites
                                            KEGG Genes - Molecular building blocks of life in the genomic space.
                                            MARRVEL_MODEL - MARRVEL (model organism gene)
                                            Linkouts
                                            BioGRID - A database of protein and genetic interactions.
                                            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                            DroID - A comprehensive database of gene and protein interactions.
                                            DRSC - Results frm RNAi screens
                                            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                            Flygut - An atlas of the Drosophila adult midgut
                                            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                                            MIST (protein-protein) - An integrated Molecular Interaction Database
                                            References (90)