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General Information
Symbol
Dmel\Atg9GD2029
Species
D. melanogaster
Name
FlyBase ID
FBal0198791
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Atg9RNAi, UAS-Atg9-RNAi
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The expression of Atg9GD2029 under the control of Scer\GAL4ap-md544 does not affect the curvature of the wing.

Flies expressing Atg9GD2029 under the control of Scer\GAL4Mef2.PU display progressive heart defects: thicker heart walls and a distorted lumen with a rough surface in older flies, increased systolic dimension throughout adult life, but no change in diastolic dimension and fractional shortening. Mitochondria in cardiomyocytes are abnormally elongated and narrowed, the mitochondrial network appears fused/enlarged and the mitochondrial volume density is significantly increased in 40-day old flies. Alongside, indirect flight muscles display fragmented mitochondria and reduced mitochondrial volume density. Neither males nor females display climbing defects.

Expression of Atg9GD2029 under the control of either Scer\GAL4esg-NP5130 of Scer\GAL4Myo31DF-NP0001 results in impaired intestinal stem cell proliferation in response to paraquat.

Flies expressing Atg9GD2029 under the control of Scer\GAL4GMR.PU show no defects in ommatidial structure.

Adults expressing Atg9GD2029 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Expression of Atg9GD2029 under the control of Scer\GAL4Act5C.PU suppresses the resistance to paraquat seen in pucB48/+ mutant flies. Mortality rates are increased compared to controls.

Expression of Atg9GD2029 suppresses the increase in cell death (cleaved caspase-3 levels) observed in response to paraquat when Atg12dsRNA.Scer\UAS is expressed under the control of Scer\GAL4Act5C.PU.

Xenogenetic Interactions
Statement
Reference

Co-expression of Atg9GD2029 partially suppresses the decreased muscle area, but not the increased apoptosis seen in flies expressing Zzzz\CTGi480.Scer\UAS.cGa under the control of Scer\GAL4hs.PU in response to heat shock.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Atg9GD10045
Atg9GD2029
Name Synonyms
Secondary FlyBase IDs
    References (14)