FlyBase Allele Report: Dmel\puc[B48]

General Information

Symbol

Dmel\puc^B48

Species

D. melanogaster

Name

FlyBase ID

FBal0086368

Feature type

allele

Associated gene

Dmel\puc

Associated Insertion(s)

P{lacZ}puc^B48

Carried in Construct

Also Known As

puc^B48-lacZ

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Dobens et al., 2001, Martin-Blanco et al., 1998)

Progenitor genotype

Associated Insertion(s)

P{lacZ}puc^B48

Cytology

Description

P{lacZ} insertion in the first intron.

(Martin-Blanco et al., 1998)

Allele components

Component

Use(s)

Inserted element

P{lacZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

chemical resistant | dominant

(Tang et al., 2013)

lethal | recessive

(Martin-Blanco et al., 1998)

Phenotype Manifest In

Detailed Description

Statement

Reference

Flies heterozygous for puc^B48 show increased resistance to paraquat and Ecc15-induced oxidative stress than control animals.

(Tang et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

puc^B48 has chemical resistant | dominant phenotype, suppressible by Scer\GAL4^Act5C.PU/Atg9^GD2029

(Tang et al., 2013)

puc^B48 has chemical resistant | dominant phenotype, suppressible by Traf6^GD7146/Scer\GAL4^Act5C.PU

(Tang et al., 2013)

puc^B48 has chemical resistant | dominant phenotype, suppressible by Scer\GAL4^Act5C.PU/Atg12^RNAi.UAS

(Tang et al., 2013)

Other

Statement

Reference

Atg9^GD2029, Scer\GAL4^Act5C.PU, puc^B48 has chemical sensitive phenotype

(Tang et al., 2013)

Scer\GAL4^Act5C.PU, Traf6^GD7146, puc^B48 has chemical sensitive phenotype

(Tang et al., 2013)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Atg9^GD2029 under the control of Scer\GAL4^Act5C.PU suppresses the resistance to paraquat seen in puc^B48/+ mutant flies. Mortality rates are increased compared to controls.

Expression of Traf6^GD7146 under the control of Scer\GAL4^Act5C.PU suppresses the resistance to paraquat seen in puc^B48/+ mutant flies. Mortality rates are increased compared to controls.

Expression of Atg12^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Act5C.PU does not suppress the resistance to paraquat seen in puc^B48/+ mutant flies.

(Tang et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

puc^E69

(Martin-Blanco et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Puc^B48

(Tang et al., 2013)

puc^B48

(Tang et al., 2013)

pucB48

(Tang et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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