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FB2026_01
,
released March 12, 2026
mm, cht, chaste, l(2)01038, l(2)k01212
RNA splice factor involved in terminal muscle and eye differentiation - mutants model features of myotonic dystrophy
Please see the JBrowse view of Dmel\mbl for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Alternative translation stop created by use of multiphasic reading frames within coding region.
Gene model reviewed during 6.02
Gene model reviewed during 6.33
Gene model reviewed during 6.53
Gene model reviewed during 5.47
Gene model reviewed during 5.45
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts may not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.42
Gene model reviewed during 5.48
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
A subset of the transcripts annotated for this gene are postulated to be circular mRNAs (FBrf0193093, FBrf0236596, FBrf0253324).
3.846, 3.037, 2.990, 2.936 (longest cDNA)
None of the polypeptides share 100% sequence identity.
316, 243, 203, 84 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mbl using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
mbl protein is detected in the nuclei of ommatidial precluster cells and at lower levels in the nuclei of all imaginal disc cells.
Comment: subset of neuronal cell bodies in the adult brain cortex
Comment: adult brain cortex, higher around central brain
JBrowse - Visual display of RNA-Seq signals
View Dmel\mbl in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
monoclonal
mbl function is required for tendon matrix deposition at muscle attachments and for Z-band formation.
Molecular analysis reveals the mbl locus is large and complex, giving rise to multiple different proteins with common 5' sequences but different carboxy termini.
Mutant females persistently repel male approaches throughout their life.
Source for merge of: mbl mm
Source for merge of: mm l(2)k01212
Source for merge of: mbl l(2)01038
Source for merge of: mbl chaste
Annotations CG14477, CG10941 merged as CG33197 (mbl) in release 3 of the genome annotation.
"l(2)07129" may correspond to "mm"; the P{PZ} insertion in the "l(2)0712907129" allele maps 61bp upstream of the 5' end of the CT30649 transcript of "mm". However, "l(2)0712907129" complements "mmk07110" (these alleles are caused by P-element insertions at the same site, the elements are P{PZ} and P{lacW} respectively).
Relationship between "chaste" and "mm" is unclear.
Reflecting that the phenotype is the development of the visual system and the muscle the gene is named "mbl", "muscleblind".
