FlyBase Allele Report: Dmel\mbl[KG08885]

General Information

Symbol

Dmel\mbl^KG08885

Species

D. melanogaster

Name

FlyBase ID

FBal0147019

Feature type

allele

Associated gene

Dmel\mbl

Associated Insertion(s)

P{SUPor-P}mbl^KG08885

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{SUPor-P}mbl^KG08885

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{SUPor-P}

insertional mutagenesis tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:17,344,433..17,344,433 [-]

(Irion, 2012, Sofola et al., 2007, de Haro et al., 2006, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates myotonic dystrophy type 2

modeled by Zzzz\CCTG^UAS.106

(Yenigun et al., 2017)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Heterozygous mbl^KG08885 has no effect on eye morphology.

(de Haro et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

mbl[+]/mbl^KG08885 is an enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.PF, Zzzz\CTG^i480.UAS

(de Haro et al., 2006)

mbl[+]/mbl^KG08885 is an enhancer of abnormal neuroanatomy | adult stage phenotype of Scer\GAL4^GMR.PF, Zzzz\CTG^i480.UAS

(de Haro et al., 2006)

mbl[+]/mbl^KG08885 is an enhancer of abnormal size | adult stage phenotype of Scer\GAL4^GMR.PF, Zzzz\CTG^i480.UAS

(de Haro et al., 2006)

Phenotype Manifest In

Enhancer of

Statement

Reference

mbl[+]/mbl^KG08885 is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, Zzzz\CTG^i480.UAS

(de Haro et al., 2006)

mbl[+]/mbl^KG08885 is an enhancer of ommatidium phenotype of Scer\GAL4^GMR.PF, Zzzz\CTG^i480.UAS

(de Haro et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

One copy of mbl^KG08885 enhances the eye phenotypes seen when Zzzz\CTG^{i480.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PF. The amount of ommatidial disorganisation/fusion is increased and the eye is further reduced in size.

(de Haro et al., 2006)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

15144

y¹; P{SUPor-P}mbl^KG08885/CyO; ry⁵⁰⁶

Kyoto

114407

y^d2 w¹¹¹⁸ P{ey-FLP.N}2; P{neoFRT}42D P{SUPor-P}mbl^KG08885 /CyO y⁺

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

MBNL1^LOF

(de Haro et al., 2006)

mbl^KG08885

(Yenigun et al., 2017)

mbl^P15144

(de Haro et al., 2006)

mbn^P15144

(Sofola et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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