FlyBase Allele Report: Dmel\mbl[k05507b]

General Information

Symbol

Dmel\mbl^k05507b

Species

D. melanogaster

Name

FlyBase ID

FBal0082448

Feature type

allele

Associated gene

Dmel\mbl

Associated Insertion(s)

P{lacW}mbl^k05507b

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Begemann et al., 1997)

Mutagen

P-element activity

(Begemann et al., 1997)

Progenitor genotype

Associated Insertion(s)

P{lacW}mbl^k05507b

Cytology

Description

P{lacW} insertion in the 5' untranslated region.

(Begemann et al., 1997)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of myotonic dystrophy type 2

CEA

(Machuca-Tzili et al., 2006)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal courtship behavior | female (with mbl^chst)

(Juni and Yamamoto, 2009)

lethal (with mbl^chst-exC3)

(Juni and Yamamoto, 2009)

lethal (with mbl^chst-exC45)

(Juni and Yamamoto, 2009)

lethal (with mbl^chst-exC110)

(Juni and Yamamoto, 2009)

lethal (with mbl^chst-exS31)

(Juni and Yamamoto, 2009)

lethal (with mbl^E27)

(Juni and Yamamoto, 2009)

lethal (with mbl^E127)

(Juni and Yamamoto, 2009)

lethal | recessive

(Spradling et al., 1999)

lethal - all die during embryonic stage | recessive

(Begemann et al., 1997)

partially lethal - majority die (with mbl^E2563-12)

(Juni and Yamamoto, 2009)

partially lethal - majority die (with mbl^k07110)

(Juni and Yamamoto, 2009)

some die during embryonic stage | recessive

(Begemann et al., 1997)

viable (with mbl^chst)

(Juni and Yamamoto, 2009)

viable (with mbl^k07103)

(Juni and Yamamoto, 2009)

Phenotype Manifest In

rhabdomere R2

(Begemann et al., 1997)

rhabdomere R3

(Begemann et al., 1997)

rhabdomere R4

(Begemann et al., 1997)

rhabdomere R5

(Begemann et al., 1997)

Detailed Description

Statement

Reference

mbl^chst/mbl^k05507b females show reduced sexual receptivity compared to controls.

(Juni and Yamamoto, 2009)

Mutant clones in the eye exhibit phenotypic defects in many mutant ommatidia, the rhabdomeres of up to 4 outer photoreceptors have a smaller diameter resembling the rhabdomeres of receptor cell R7. All photoreceptors could be affected with malformed rhabdomeres that frequently do not extend into basal regions of the retina.

(Begemann et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

mbl^k05507b is a suppressor of visible phenotype of svp^2.sev

(Begemann et al., 1997)

Phenotype Manifest In