FlyBase Allele Report: Dmel\svp[2.sev]

General Information

Symbol

Dmel\svp^2.sev

Species

D. melanogaster

Name

FlyBase ID

FBal0032837

Feature type

allele

Associated gene

Dmel\svp

Associated Insertion(s)

Carried in Construct

P{sev-svp2}

Also Known As

sev-svp

Key Links

Transgenic product class

cDNA

(Hiromi et al., 1993)

wild_type

(Hiromi et al., 1993)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Hiromi et al., 1993)

wild_type

(Hiromi et al., 1993)

Mutagen

in vitro construct

(Begemann et al., 1995, Kramer et al., 1995, Hiromi et al., 1993)

Progenitor genotype

Carried in construct

P{sev-svp2}

Cytology

Description

svp type 2 cDNA expressed from a sev enhancer/promoter cassette.

(Hiromi et al., 1993)

Allele components

Component

Use(s)

Regulatory region(s)

sev

Encoded product / tool

svp

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Pazman et al., 2000, Begemann et al., 1997)

Phenotype Manifest In

cone cell

(Kramer et al., 1995, Weber et al., 1995)

eye

(Pazman et al., 2000, Zeidler et al., 1996)

eye photoreceptor cell

(Begemann et al., 1997)

photoreceptor cell R7

(Kramer et al., 1995, Weber et al., 1995, Hiromi et al., 1993)

Detailed Description

Statement

Reference

Extra inner R7 photoreceptors in many ommatidia.

(Begemann et al., 1997)

One copy causes mild external eye roughening, two copies enhance the roughening. Dosage-dependent (two or more copies of P{sev-svp2}) transformation of cone cells into R7 photoreceptors and at a lower frequency R7 cells into outer photoreceptors. Also an increasing number of ommatidia have malformed and collapsed lenses.

(Begemann et al., 1995)

Rough eye phenotype. Transformation of cone cells towards R7 neurons. Increased copies of P{sev-svp1} cause ommatidia to contain seven or more outer photoreceptors and one or more R7 cells, this represents a transformation of R7 to an outer photoreceptor.

(Kramer et al., 1995)

Transformation of cone cells and photoreceptor cell 7 to photoreceptor cell 7 or outer photoreceptors.

(Weber et al., 1995)

Eye roughening, due to cone cells being transformed into extra photoreceptor R7-like cells. Extra cells are recruited to become cone cells: there is no depletion of cone cell numbers. sina, but neither sev nor boss, is required for this cone cell transformation.

(Hiromi et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

svp^2.sev has visible phenotype, enhanceable by mbl^A.sev

(Begemann et al., 1997)

Suppressed by

Statement

Reference

svp^2.sev has visible phenotype, suppressible by rin¹/rin[+]

(Pazman et al., 2000)

svp^2.sev has visible phenotype, suppressible by mbl^k05507b

(Begemann et al., 1997)

svp^2.sev has visible phenotype, suppressible by mbl^E27

(Begemann et al., 1997)

Phenotype Manifest In

Enhanced by

Statement

Reference

svp^2.sev has eye photoreceptor cell phenotype, enhanceable by mbl^A.sev

(Begemann et al., 1997)

svp^2.sev has phenotype, enhanceable by mbl^B.sev

(Begemann et al., 1997)

svp^2.sev has phenotype, enhanceable by sev^S11.Tag:MYC

(Begemann et al., 1995)

svp^2.sev has phenotype, enhanceable by RasGAP1^rI533

(Begemann et al., 1995)

svp^2.sev has phenotype, enhanceable by Ras85D^V12.sev

(Begemann et al., 1995)

svp^2.sev has phenotype, enhanceable by Sos^JC2

(Begemann et al., 1995)

svp^2.sev has phenotype, enhanceable by aop^A141

(Begemann et al., 1995)

svp^2.sev has phenotype, enhanceable by aop^yan-1

(Begemann et al., 1995)

svp^2.sev has phenotype, enhanceable by Raf::tor^12D.hs.sev

(Begemann et al., 1995)

svp^2.sev has phenotype, enhanceable by rl^Sem

(Begemann et al., 1995)

Suppressed by

Statement

Reference

svp^2.sev has eye phenotype, suppressible by rin¹/rin[+]

(Pazman et al., 2000)

svp^2.sev has eye photoreceptor cell phenotype, suppressible by mbl^k05507b

(Begemann et al., 1997)

svp^2.sev has eye photoreceptor cell phenotype, suppressible by mbl^E27

(Begemann et al., 1997)

svp^2.sev has eye phenotype, suppressible by TfIIA-S^E73

(Zeidler et al., 1996)

svp^2.sev has phenotype, suppressible by Egfr^f11

(Begemann et al., 1995)

svp^2.sev has phenotype, suppressible by Egfr^t1

(Begemann et al., 1995)

svp^2.sev has phenotype, suppressible by Raf¹

(Begemann et al., 1995)

svp^2.sev has phenotype, suppressible by Raf⁷

(Begemann et al., 1995)

svp^2.sev has phenotype, suppressible by phyl^odin17L1

(Begemann et al., 1995)

svp^2.sev has phenotype, suppressible by phyl^odin3G6

(Begemann et al., 1995)

svp^2.sev has phenotype, suppressible by rl¹⁰

(Begemann et al., 1995)

svp^2.sev has phenotype, suppressible by rl^10a

(Begemann et al., 1995)

svp^2.sev has phenotype, suppressible by Egfr^F15

(Kramer et al., 1995)

svp^2.sev has phenotype, suppressible by Egfr^f3

(Kramer et al., 1995)

svp^2.sev has phenotype, suppressible by Ras85D^C33

(Kramer et al., 1995)

svp^2.sev has phenotype, suppressible by Ras85D^e2F

(Begemann et al., 1995, Kramer et al., 1995)

svp^2.sev has phenotype, suppressible by Sos^F1

(Kramer et al., 1995)

svp^2.sev has phenotype, suppressible by Sos^e4G

(Begemann et al., 1995, Kramer et al., 1995)

svp^2.sev has phenotype, suppressible by csw^Esev1A-eOP

(Begemann et al., 1995, Kramer et al., 1995)

svp^2.sev has phenotype, suppressible by Raf^LQ129

(Kramer et al., 1995)

svp^2.sev has phenotype, suppressible by rl^15M1

(Kramer et al., 1995)

svp^2.sev has phenotype, suppressible by Egfr^A3

(Kramer et al., 1995)

svp^2.sev has phenotype, suppressible by Egfr^B24

(Kramer et al., 1995)

svp^2.sev has phenotype, suppressible by Df(2R)17

(Weber et al., 1995)

svp^2.sev has phenotype, suppressible by Df(2R)27

(Weber et al., 1995)

svp^2.sev has phenotype, suppressible by psq^D91

(Weber et al., 1995)

svp^2.sev has phenotype, suppressible by psq^E39

(Weber et al., 1995)

Other

Statement

Reference

sina¹/sina³, svp^2.sev has photoreceptor cell R7 phenotype

(Hiromi et al., 1993)

Additional Comments

Genetic Interactions

Statement

Reference

Phenotype can be suppressed by mbl^k05507b and mbl^E27, most ommatidia have a wild-type appearance. Phenotype can be enhanced by mbl^A.sev, many ommatidia contain extra photoreceptors of the outer type, up to 11 outer photoreceptors instead of the normal 6.

(Begemann et al., 1997)

TfIIA-S^E73 suppresses the rough eye phenotype of sev^{S11.T:Hsap\MYC}, phl::tor^12D.hs.sev, Ras85D^V12.sev, rl^Sem and svp^2.sev.

(Zeidler et al., 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Phenotype depends on C terminal portion of the protein, see svp^sev.ΔMlu, svp^sev.ΔSal and svp^sev.ΔSal.

(Hiromi et al., 1993)

Cone cell transformation can be dominantly suppressed by mutations in components of the Ras85D signal transduction cascade. Mutations in negative regulators of Ras85D activity act as dominant enhancers.

(Begemann et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

svp^2.sev

Name Synonyms

Secondary FlyBase IDs

References (10)

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