aopyan-1/aopA141 eye discs show chirality defects in 9.4% of ommatidial clusters.
aopyan-1/aope2d eye discs show chirality defects in ommatidial clusters.
Border cell migration is significantly delayed in egg chambers with aopyan-1 mitotic clones.
Stage 16 aopyan-1 homozygous embryos have more oenocytes per cluster than wild-type. Unlike rhoScer\UAS.cdCa; Scer\GAL4en-e16E the oenocyte clusters in these embryos do not show a multi-modal distribution of cell numbers with peaks corresponding to multiples of 3, suggesting that normal delamination cycles in groups of 3 are not occurring.
Mutant embryos show an increase in the number of lateral adult muscle precursors and the segmental border muscle fibres are enlarged.
Ectopic R7 development, which is precocious relative to the morphogenetic furrow, is seen in third instar eye discs.
In aopyan-1 mutants 90% of the ommatidia contain between one and four (average 2.0) supernumerary R7-like cells. 27% of the ommatidia contain one or two extra outer photoreceptor cells, while 6% of the ommatidia lack one or two outer photoreceptor cells.
Embryos exhibit a reduction in number of midline glial cells.
The formation of extra R7 cells in aop mutants is independent of lilli.
Suppressed by phyl2366. The phyl2366 mutation completely suppresses the supernumerary R7 phenotype of aop and Gap1 mutations.
The formation of additional R7 cells requires phyl+.
Adult escapers exhibit a mild rough eye phenotype. Transheterozygotes with Df(2L)dp-79b or aope2d are also semi-lethal with escapers exhibiting a mild rough eye phenotype. Transheterozygotes with aoppok-x8 are viable with mild rough eyes.
Homozygotes have reduced viability and fertility, about 20% reach adulthood. Embryos have abnormalities in germband retraction and tracheal structure. Homozygotes exhibit a rough eye phenotype, 88% ommatidia contain between 1 and 4 supernumerary R7-like cells, at the expense of cone cell precursors, some of the ommatidia also contain extra outer photoreceptor cells and fewer have a reduced number of outer photoreceptor cells. Hemizygotes exhibit the same phenotype. Eye discs exhibit two classes of defects: extra elav-positive cells begin to appear at an early stage of ommatidial development and irregular spacing and orientation of ommatidia. Mosaic analysis demonstrates the mutation acts cell-autonomously to generate supernumerary R7 cells.