Open Close
General Information
Symbol
Dmel\aopyan-1
Species
D. melanogaster
Name
FlyBase ID
FBal0034185
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
yan1
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the P-element, deletion extends from within the P-element to flanking genomic DNA causing a small deletion near the insertion site.

Insertion components
P{?'lwB}aopyan-1
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

aopyan-1/aopA141 eye discs show chirality defects in 9.4% of ommatidial clusters.

aopyan-1/aope2d eye discs show chirality defects in ommatidial clusters.

Border cell migration is significantly delayed in egg chambers with aopyan-1 mitotic clones.

Stage 16 aopyan-1 homozygous embryos have more oenocytes per cluster than wild-type. Unlike rhoScer\UAS.cdCa; Scer\GAL4en-e16E the oenocyte clusters in these embryos do not show a multi-modal distribution of cell numbers with peaks corresponding to multiples of 3, suggesting that normal delamination cycles in groups of 3 are not occurring.

Mutant embryos show an increase in the number of lateral adult muscle precursors and the segmental border muscle fibres are enlarged.

Ectopic R7 development, which is precocious relative to the morphogenetic furrow, is seen in third instar eye discs.

In aopyan-1 mutants 90% of the ommatidia contain between one and four (average 2.0) supernumerary R7-like cells. 27% of the ommatidia contain one or two extra outer photoreceptor cells, while 6% of the ommatidia lack one or two outer photoreceptor cells.

14-3-3εS-696 does not show any dominant interaction with aopyan-1.

Embryos exhibit a reduction in number of midline glial cells.

The formation of extra R7 cells in aop mutants is independent of lilli.

Suppressed by phyl2366. The phyl2366 mutation completely suppresses the supernumerary R7 phenotype of aop and Gap1 mutations.

The formation of additional R7 cells requires phyl+.

Adult escapers exhibit a mild rough eye phenotype. Transheterozygotes with Df(2L)dp-79b or aope2d are also semi-lethal with escapers exhibiting a mild rough eye phenotype. Transheterozygotes with aoppok-x8 are viable with mild rough eyes.

Homozygotes have reduced viability and fertility, about 20% reach adulthood. Embryos have abnormalities in germband retraction and tracheal structure. Homozygotes exhibit a rough eye phenotype, 88% ommatidia contain between 1 and 4 supernumerary R7-like cells, at the expense of cone cell precursors, some of the ommatidia also contain extra outer photoreceptor cells and fewer have a reduced number of outer photoreceptor cells. Hemizygotes exhibit the same phenotype. Eye discs exhibit two classes of defects: extra elav-positive cells begin to appear at an early stage of ommatidial development and irregular spacing and orientation of ommatidia. Mosaic analysis demonstrates the mutation acts cell-autonomously to generate supernumerary R7 cells.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

aopyan-1/aop[+] is an enhancer of visible phenotype of fafBX4

Phenotype Manifest In
Suppressed by
Statement
Reference

aopyan-1 has phenotype, suppressible by SosEY2-3

aopyan-1 has phenotype, suppressible by prosJO1

Enhancer of
Statement
Reference

aopyan-1/aop[+] is an enhancer of photoreceptor cell R7 | ectopic phenotype of sty226

aopyan-1/aop[+] is an enhancer of photoreceptor cell R1 | ectopic phenotype of fafBX4

aopyan-1/aop[+] is an enhancer of photoreceptor cell R2 | ectopic phenotype of fafBX4

aopyan-1/aop[+] is an enhancer of photoreceptor cell R3 | ectopic phenotype of fafBX4

aopyan-1/aop[+] is an enhancer of photoreceptor cell R4 | ectopic phenotype of fafBX4

aopyan-1/aop[+] is an enhancer of photoreceptor cell R5 | ectopic phenotype of fafBX4

aopyan-1/aop[+] is an enhancer of photoreceptor cell R6 | ectopic phenotype of fafBX4

aopyan-1 is an enhancer of phenotype of svp2.sev

aopyan-1 is an enhancer of phenotype of svp1.sev

aopyan-1 is an enhancer of phenotype of JraAsp.hs.sev

aopyan-1 is an enhancer of eye phenotype of rhohs.sev

Suppressor of
NOT Suppressor of
Statement
Reference

aopyan-1 is a non-suppressor of ommatidium phenotype of Rac1V12.hs.sev

Other
Additional Comments
Genetic Interactions
Statement
Reference

Enhances the extra-R7 cell eye phenotype of sty226/+ heterozygotes.

Significantly enhances the formation of extra outer photoreceptors caused by B-H1sev.PH. aopyan-1 flies carrying B-H1sev.PH have a considerable number of extra R7-like cells.

The extra outer photoreceptor cell phenotype seen in fafBX4 homozygotes is dominantly enhanced by aopyan-1, with the average number of outer photoreceptor cells per ommatidium being increased to 8.7.

Loss of wild type ttk promotes the formation of rare ectopic R7 cells.

No effect on the faf eye phenotype.

Enhancer of the dosage-dependent (two or more copies of P{sev-svp1} or P{sev-svp2}) transformation of cone cells into R7 photoreceptors and at a lower frequency R7 cells into outer photoreceptors.

sev6/sev+; SosJC2/aoppok-x8 mutants exhibit an increase in the number of R7 cells compared to sev6/SosJC2 mutants with two functional aop copies.

Dominantly enhances the rough eye phenotype of JraAsp.hs.sev.

Reduction in the dose of aop enhances all the defects seen in rhohs.sev eyes.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially complements
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
References (35)