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Citation
Scholz, H., Sadlowski, E., Klaes, A., Klambt, C. (1997). Control of midline glia development in the embryonic Drosophila CNS.  Mech. Dev. 64(1-2): 137--151.
FlyBase ID
FBrf0096245
Publication Type
Erratum
Abstract

The midline glial cells are required for correct formation of the axonal pattern in the embryonic ventral nerve cord of Drosophila. Initially, six midline cells form an equivalence group with the capacity to develop as glial cells. By the end of embryonic development three to four cells are singled out as midline glial cells. Midline glia development occurs in two steps, both of which depend on the activation of the Drosophila EGF-receptor homolog and subsequent ras1/raf-mediated signal transduction. Nuclear targets of this signalling cascade are the ETS domain transcription factors pointedP2 and yan. In the midline glia pointedP2 in turn activates the transcription of argos, which encodes a diffusible negative regulator of EGF-receptor signalling.

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Related Publication(s)
Research paper

Control of midline glia development in the embryonic Drosophila CNS.
Scholz et al., 1997, Mech. Dev. 62(1): 79--91 [FBrf0093209]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Mech. Dev.
    Title
    Mechanisms of Development
    Publication Year
    1990-
    ISBN/ISSN
    0925-4773
    Data From Reference