18.7% of ommatidia have an R7 cell in sev6; SosJC2 flies. This partial rescue of sev6 by SosJC2 is relieved by rin1 or rin2; 13.9% and 18.2% of ommatidia have an R7 cell in sev6 ; SosJC2/+ ; rin1/+ and sev6; SosJC2/+ ; rin2/+ flies respectively.
28.7% of ommatidia have an R7 cell in sev6 ; SosJC2 flies. This partial rescue of sev6 by SosJC2 is relieved by rin1 or rin2; 13.9% and 18.2% of ommatidia have an R7 cell in sev6 ; SosJC2/+ ; rin1/+ and sev6 ; SosJC2/+ ; rin2/+ flies respectively.
In sev6/Y;SosJC2/+ flies. all outer photoreceptor cells form normally whereas the R7 cells form in only 21% of the ommatidia. The addition of sag13L enhances this phenotype so that R7 cells form in only 0.7% of ommatidia.
In sev6 hemizygotes that are also heterozygous for SosJC2, 14.7% of ommatidia contain R7 cells. This phenotype is dominantly enhanced by Egfrf2, ebiE4 and ebiE90, and dominantly suppressed by ttk1 and ttk00219.
Some ommatidia of male hemizygotes or heterozygotes with SosJC2 contain R7 cells, this rough eye phenotype can be rescued by the rlhs.PB construct. Removing one copy of rl enhances this phenotype but is suppressed by increase in copy number of other members of the sev signalling pathway.
Partially suppressed the R7 phenotype of SosJC2 : Double mutants have R7 cells in 16% of ommatidia, in contrast to 0% in sev6 alone. This suppression is almost entirely reversed if the flies are also made hetozygous for ast1 or ast4.
The homozygous phenotype is partly suppressed by SosJC2; homozygous flies carrying one copy of SosJC2 have R7 cells in 16% of their ommatidia. Flies doubly homozygous for sev6 and boss1 and also heterozygous for SosJC2 have no R7 photoreceptor cells. Flies homozygous for sev6, heterozygous for SosJC2 and heterozygous for either Df(3R)by62 or Df(3R)by10 have no R7 photoreceptor cells.
Dominant suppression of the sev6 phenotype when in combination with SosJC2, a fraction of the ommatidia contain R7 cells. This suppression is repressed by one copy of boss1 due to loss of the boss-dependent ligand of the sev receptor. Wild type Sos gene product provides lower levels of suppression and loss of function Sos alleles even lower.