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General Information
Symbol
Dmel\sev6
Species
D. melanogaster
Name
FlyBase ID
FBal0015450
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
sevE4
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The R7 photoreceptors fail to develop in homozygous sev6 flies.

R7 photoreceptor cells are absent in hemizygotes. Hemizygotes carrying one copy of SosJC2 have R7 cells in 18.5% of their ommatidia. The proportion of ommatidia containing an R7 cell is reduced if the flies also carry one copy of klgH214, klgE226, klgE1432 or Df(3R)hh.

Hemizygous flies lack R7 photoreceptor cells in the ommatidia.

In sev6; SosJC2 double heterozygotes an R7 cell develops in only 17% of the ommatidia. Raising the level of Cbl using Cblhs.2sev essentially eliminates development of R7 cells.

No R7 cells develop. In sev6/Y;SosJC2/+, 17% of ommatidia have R7 cells. 30% of sev6/Y;SosNCatC.hs.sev ommatidia have R7 cells, 23% of sev6/Y;SosNCat.hs.sev ommatidia have R7 cells.

sev6/SosJC2 is a sensitive genetic background that can be used to analyse the effect on R7 development of aop alleles. In this flies only 16% of R7 cells in the ommatidia develop. Removal of one copy of aop causes an increase in the number of R7 cells.

Homozygous flies have no R7 photoreceptor cells.

Homozygous ommatidia lack photoreceptor cell R7. Ommatidia of double mutants with Gap1sxt-BJ61 display extra R7 cells. R7 cells develop in only 17% of sev6/sev6; SosJC2/Sos+ ommatidia. Loss of one wild type copy of boss or Ras85D reduces the suppression to 0%. Loss of a single copy of Gap1 causes R7 cells to develop in half the ommatidia.

positive phototaxis with Ppb/+

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference

sev6 has visible | recessive phenotype, suppressible by SKojak

Phenotype Manifest In
Enhanced by
Statement
Reference

SosJC2, sev6 has photoreceptor cell R7 phenotype, enhanceable by rin2/rin[+]

SosJC2, sev6 has photoreceptor cell R7 phenotype, enhanceable by rin1/rin[+]

SosJC2, sev6 has ommatidium phenotype, enhanceable by cnksag13L

SosJC2/Sos[+], sev6 has ommatidium phenotype, enhanceable by Egfr[+]/Egfrf2

SosJC2/Sos[+], sev6 has photoreceptor cell R7 phenotype, enhanceable by Egfr[+]/Egfrf2

SosJC2/Sos[+], sev6 has ommatidium phenotype, enhanceable by ebi[+]/ebiE4

SosJC2/Sos[+], sev6 has photoreceptor cell R7 phenotype, enhanceable by ebi[+]/ebiE4

SosJC2/Sos[+], sev6 has ommatidium phenotype, enhanceable by ebiE90/ebi[+]

SosJC2/Sos[+], sev6 has photoreceptor cell R7 phenotype, enhanceable by ebiE90/ebi[+]

SosJC2, sev6 has ommatidium phenotype, enhanceable by Egfr[+]/Egfrf2

SosJC2, sev6 has photoreceptor cell R7 phenotype, enhanceable by Egfr[+]/Egfrf2

SosJC2, sev6 has ommatidium phenotype, enhanceable by ebi[+]/ebiE4

SosJC2, sev6 has photoreceptor cell R7 phenotype, enhanceable by ebi[+]/ebiE4

SosJC2, sev6 has ommatidium phenotype, enhanceable by ebiE90/ebi[+]

SosJC2, sev6 has photoreceptor cell R7 phenotype, enhanceable by ebiE90/ebi[+]

SosJC2, sev6 has photoreceptor cell R7 phenotype, enhanceable by ast[+]/ast1

SosJC2, sev6 has photoreceptor cell R7 phenotype, enhanceable by ast4/ast[+]

SosJC2, sev6 has photoreceptor cell R7 phenotype, enhanceable by S[+]/S104E

Suppressed by
Statement
Reference

sev6 has phenotype, suppressible | partially by SosJC2

SosJC2, sev6 has photoreceptor cell R7 phenotype, suppressible | partially by ttk[+]/ttk1

SosJC2, sev6 has ommatidium phenotype, suppressible | partially by ttk[+]/ttk00219

SosJC2, sev6 has photoreceptor cell R7 phenotype, suppressible | partially by ttk[+]/ttk00219

SosJC2/Sos[+], sev6 has ommatidium phenotype, suppressible | partially by ttk[+]/ttk1

SosJC2/Sos[+], sev6 has photoreceptor cell R7 phenotype, suppressible | partially by ttk[+]/ttk1

SosJC2/Sos[+], sev6 has ommatidium phenotype, suppressible | partially by ttk[+]/ttk00219

SosJC2/Sos[+], sev6 has photoreceptor cell R7 phenotype, suppressible | partially by ttk[+]/ttk00219

SosJC2, sev6 has ommatidium phenotype, suppressible | partially by ttk[+]/ttk1

sev6 has photoreceptor cell R7 phenotype, suppressible by SKojak

sev6 has phenotype, suppressible by Dsor1Su12

sev6 has phenotype, suppressible by Dsor1Su18

sev6 has phenotype, suppressible by Dsor1Su1

sev6 has phenotype, suppressible by Dsor1Su24

sev6 has phenotype, suppressible by Dsor1Su4

sev6 has phenotype, suppressible by Dsor1Su6

sev6 has phenotype, suppressible by Dsor1Su7

SosJC2, sev6 has photoreceptor cell R7 phenotype, suppressible by aop1

SosJC2, sev6 has photoreceptor cell R7 phenotype, suppressible by aop2

SosJC2, sev6 has photoreceptor cell R7 phenotype, suppressible by aope2d

sev6 has phenotype, suppressible by SosJC2

sev6 has photoreceptor cell R7 phenotype, suppressible by SosJC2

Suppressor of
Statement
Reference
Other
Additional Comments
Genetic Interactions
Statement
Reference

18.7% of ommatidia have an R7 cell in sev6; SosJC2 flies. This partial rescue of sev6 by SosJC2 is relieved by rin1 or rin2; 13.9% and 18.2% of ommatidia have an R7 cell in sev6 ; SosJC2/+ ; rin1/+ and sev6; SosJC2/+ ; rin2/+ flies respectively.

28.7% of ommatidia have an R7 cell in sev6 ; SosJC2 flies. This partial rescue of sev6 by SosJC2 is relieved by rin1 or rin2; 13.9% and 18.2% of ommatidia have an R7 cell in sev6 ; SosJC2/+ ; rin1/+ and sev6 ; SosJC2/+ ; rin2/+ flies respectively.

In sev6/Y;SosJC2/+ flies. all outer photoreceptor cells form normally whereas the R7 cells form in only 21% of the ommatidia. The addition of sag13L enhances this phenotype so that R7 cells form in only 0.7% of ommatidia.

In sev6 hemizygotes that are also heterozygous for SosJC2, 14.7% of ommatidia contain R7 cells. This phenotype is dominantly enhanced by Egfrf2, ebiE4 and ebiE90, and dominantly suppressed by ttk1 and ttk00219.

The sev6 phenotype is partly suppressed by SKojak; sev6/sev6 ; SKojak/+ flies have an R7 cell in approximately 50% of the ommatidia.

The lack of R7 photoreceptor cells seen in sev6 hemizygotes is partly suppressed by Dsor1Su1, Dsor1Su4, Dsor1Su6, Dsor1Su7, Dsor1Su12, Dsor1Su18 and Dsor1Su24.

Some ommatidia of male hemizygotes or heterozygotes with SosJC2 contain R7 cells, this rough eye phenotype can be rescued by the rlhs.PB construct. Removing one copy of rl enhances this phenotype but is suppressed by increase in copy number of other members of the sev signalling pathway.

Partially suppressed the R7 phenotype of SosJC2 : Double mutants have R7 cells in 16% of ommatidia, in contrast to 0% in sev6 alone. This suppression is almost entirely reversed if the flies are also made hetozygous for ast1 or ast4.

The homozygous phenotype is partly suppressed by SosJC2; homozygous flies carrying one copy of SosJC2 have R7 cells in 16% of their ommatidia. Flies doubly homozygous for sev6 and boss1 and also heterozygous for SosJC2 have no R7 photoreceptor cells. Flies homozygous for sev6, heterozygous for SosJC2 and heterozygous for either Df(3R)by62 or Df(3R)by10 have no R7 photoreceptor cells.

Dominant suppression of the sev6 phenotype when in combination with SosJC2, a fraction of the ommatidia contain R7 cells. This suppression is repressed by one copy of boss1 due to loss of the boss-dependent ligand of the sev receptor. Wild type Sos gene product provides lower levels of suppression and loss of function Sos alleles even lower.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Weak sev allele.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
References (17)