FlyBase Allele Report: Dmel\ast[4]

General Information

Symbol

Dmel\ast⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0000777

Feature type

allele

Associated gene

Dmel\ast

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

(Lewis, 1945)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Lewis, 1945)

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

wild-type (with ast^rv1)

(Lewis, 1945)

Phenotype Manifest In

eye

(Kolodkin et al., 1994)

ommatidium

(Kolodkin et al., 1994)

Detailed Description

Statement

Reference

Mutants have a rough eye phenotype with minor defects in ommatidial assembly.

(Kolodkin et al., 1994)

Heterozygotes and homozygotes appear wild-type, although homozygotes can show a phenotype as extreme as ast¹/ast¹ under unfavourable culture conditions.

(Lewis, 1945)

Phenotypically wild-type. Enhances expression of S¹ in heterozygotes. S¹/ast⁴ has smaller eye than S¹/+; resembles ast¹/ast¹ in wing phenotype. RK3.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

S¹, ast⁴ has visible | dominant phenotype

(Lewis, 1945)

E(S)¹, ast⁴ has visible | dominant phenotype

(Lewis, 1945)

Phenotype Manifest In

Enhanced by

Statement

Reference

ast⁴ has eye phenotype, enhanceable by E(S)¹

(Lewis, 1945)

Enhancer of

Statement

Reference

ast⁴/ast[+] is an enhancer of photoreceptor cell R7 phenotype of Sos^JC2, sev⁶

(Kolodkin et al., 1994)

ast⁴ is an enhancer of eye phenotype of S¹

(Lewis, 1945)

ast⁴ is an enhancer of phenotype of S¹

Other

Statement

Reference

S¹, ast⁴ has wing vein phenotype

(Lewis, 1945)

S¹, ast⁴ has eye phenotype

(Lewis, 1945)

Additional Comments

Genetic Interactions

Statement

Reference

The suppression of the sev⁶ R7 phenotype by Sos^JC2 is almost entirely reversed if the flies are also made heterozygous for ast¹ or ast⁴.

(Kolodkin et al., 1994)

S¹/ast⁴ flies have smaller eyes than S¹/+ flies and they also occasionally have gaps at the tips of the longitudinal wing veins. The phenotype is dominantly enhanced by E(S)¹; ast¹ E(S)¹ double heterozygotes have rough eyes.

(Lewis, 1945)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

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