FlyBase Allele Report: Dmel\aop[e2d]

General Information

Symbol

Dmel\aop^e2d

Species

D. melanogaster

Name

FlyBase ID

FBal0049301

Feature type

allele

Associated gene

Dmel\aop

Associated Insertion(s)

Carried in Construct

Also Known As

yan^e2D

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Gabay et al., 1996, Rogge et al., 1995)

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity (with aop^yan-1)

(Weber et al., 2008)

lethal - all die during embryonic stage | recessive

(Rogge et al., 1995)

partially lethal - majority die (with aop^pok-x8)

(Rogge et al., 1995)

partially lethal - majority die (with aop^yan-1)

(Rogge et al., 1995)

some die during embryonic stage | recessive

(Rogge et al., 1995)

visible (with aop^yan-1)

(Rogge et al., 1995)

Phenotype Manifest In

Bolwig organ

(Rogge et al., 1995)

cephalopharyngeal skeleton | embryonic stage

(Rogge et al., 1995)

dorsal pouch | embryonic stage

(Rogge et al., 1995)

embryonic/first instar larval cuticle | anterior | dorsal

(Rogge et al., 1995)

eye-antennal disc | embryonic stage

(Rogge et al., 1995)

ommatidium

(Rogge et al., 1995)

ommatidium (with aop^pok-x8)

(Rogge et al., 1995)

ommatidium (with aop^yan-1)

(Weber et al., 2008, Rogge et al., 1995)

photoreceptor cell R1

(Rogge et al., 1995)

photoreceptor cell R2

(Rogge et al., 1995)

photoreceptor cell R3

(Rogge et al., 1995)

photoreceptor cell R4

(Rogge et al., 1995)

photoreceptor cell R5

(Rogge et al., 1995)

photoreceptor cell R6

(Rogge et al., 1995)

photoreceptor cell R7

(Rogge et al., 1995)

photoreceptor cell R7 | ectopic (with aop^pok-x8)

(Rogge et al., 1995)

photoreceptor cell R8

(Rogge et al., 1995)

pigment cell (with aop^pok-x8)

(Rogge et al., 1995)

stomatogastric nervous system | embryonic stage

(Rogge et al., 1995)

visual primordium

(Rogge et al., 1995)

Detailed Description

Statement

Reference

aop^yan-1/aop^e2d eye discs show chirality defects in ommatidial clusters.

(Weber et al., 2008)

Heterozygotes with aop^pok-x8 or aop^yan-1 are semi-lethal and the adult escapers have small rough eyes due to fusion of ommatidia, loss of the regular pigment cell array and ectopic R7 cells.

(Rogge et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

aop[+]/aop^e2d is an enhancer of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, dgo^UAS.cFa

(Weber et al., 2012)

Suppressor of

Statement

Reference

aop[+]/aop^e2d is a suppressor of abnormal planar polarity phenotype of dsh^hs.sev.B

(Weber et al., 2008)

Other

Statement

Reference

aop[+]/aop^e2d, kay² has abnormal planar polarity | somatic clone phenotype

(Weber et al., 2008)

Phenotype Manifest In

Enhancer of

Statement

Reference

aop[+]/aop^e2d is an enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, dgo^UAS.cFa

(Weber et al., 2012)

aop[+]/aop^e2d is an enhancer of ommatidium phenotype of Egfr^E1

(Rogge et al., 1995)

NOT Enhancer of

Statement

Reference

aop[+]/aop^e2d is a non-enhancer of wing hair phenotype of Scer\GAL4^hs.2sev, dgo^UAS.cFa

(Weber et al., 2012)

Suppressor of

Statement

Reference

aop[+]/aop^e2d is a suppressor of ommatidium phenotype of dsh^hs.sev.B

(Weber et al., 2008)

aop^e2d is a suppressor of photoreceptor cell R7 phenotype of Sos^JC2, sev⁶

(Rogge et al., 1995)

aop^e2d is a suppressor of ventral denticle belt phenotype of Egfr^f1

(Rogge et al., 1995)

NOT Suppressor of

Statement

Reference

aop[+]/aop^e2d is a non-suppressor of wing hair phenotype of Scer\GAL4^hs.2sev, dgo^UAS.cFa

(Weber et al., 2012)

Other

Statement

Reference

aop[+]/aop^e2d, kay² has ommatidium | somatic clone phenotype

(Weber et al., 2008)

aop[+]/aop^e2d, kay² has eye photoreceptor cell | somatic clone phenotype

(Weber et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

aop^e2d/+ enhances the planar cell polarity (PCP) defects in the eye induced by the overexpression of dgo^Scer\UAS.cFa under the control of Scer\GAL4^hs.2sev.

(Weber et al., 2012)

Homozygous kay² clones in the eye in a aop^e2d/+ background show ommatidial chirality, rotation and photoreceptor number defects (kay² single mutant clones do not show tissue polarity defects by themselves).

One copy of aop^e2d partially suppresses the formation of symmetrical ommatidia that is seen in animals expressing dsh^hs.sev.B.

(Weber et al., 2008)

Loss of wild type ttk promotes the formation of rare ectopic R7 cells.

(Lai et al., 1997)

Heterozygotes with aop^pok-x8 or aop^yan-1 are semi-lethal and the adult escapers have small rough eyes due to fusion of ommatidia, loss of the regular pigment cell array and ectopic R7 cells. sev⁶/sev⁺;Sos^JC2/aop^e2d mutants exhibit an increase in the number of R7 cells compared to sev⁶/Sos^JC2 mutants with two functional aop copies.

sev⁶/sev⁺;Sos^JC2/aop^e2d mutants exhibit an increase in the number of R7 cells compared to sev⁶/Sos^JC2 mutants with two functional aop copies.

(Rogge et al., 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially complements

aop^yan-1

(Rogge et al., 1995)

aop^pok-x8

(Rogge et al., 1995)

Fails to complement

aop²

(Rogge et al., 1995)

aop¹

(Rogge et al., 1995)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

aop^E2d

(Weber et al., 2012)

aop^e2d

e2d

(Rogge et al., 1995)

yan^E2d

(Weber et al., 2008)

yan^e2D

(Chang et al., 2003, Flores et al., 2000)

yan^e2d

(zur Lage et al., 2004, Dumstrei et al., 1998, Lai et al., 1997, Gabay et al., 1996, Rogge et al., 1995)

Name Synonyms

Secondary FlyBase IDs

References (9)

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