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General Information
Symbol
Dmel\ast1
Species
D. melanogaster
Name
FlyBase ID
FBal0000774
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
ast
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference

Mutation is not visible cytologically. Southern blots reveal a breakpoint between coordinates -0 and +4.3.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

ast1/Df(2L)ast4 embryos have defects in the development of a subset of somatic muscles, especially muscles LL1 and DO4.

Mutants have a rough eye phenotype with minor defects in ommatidial assembly.

Transheterozygotes with astB612, astK3 or astK12 exhibit disranged ommatidia in eyes that are one to three quarters wild type size. Wing veins L2, L3, L4 and L5 do not reach the wing margin in the majority of males and occasionally in females. Transheterozygotes with astK11 exhibit disranged ommatidia in nearly wild-type sized eyes. No wing vein abnormalities are found. Transheterozygotes with astK2, astK5, astK7, astK14, astK15, astK16, astK17, astK18, astK19 or astK21 exhibit disranged ommatidia in eyes that are one to three quarters wild type size. Wing veins L2, L3, L4 and L5 do not reach the wing margin in the majority of males and occasionally in females. Transheterozygotes with astK6 or astK20 exhibit disranged ommatidia in nearly wild-type sized eyes. No wing vein abnormalities are found. Transheterozygotes with astK13 exhibit ommatidia that are very jumbled and often fused. Eyes are less than one-quarter wild type size. Wing vein abnormalities are very pronounced and present in nearly all males and females. Transheterozygotes with astK9 exhibit ommatidia that are very jumbled and often fused. Eyes are less than one-quarter wild type size. Wing vein abnormalities are very pronounced and present in nearly all males and females.

Intercalary and terminal gaps in all veins in an erratic fashion and asymmetrically in the two wings of the same individual. Abnormal eye morphology.

Homozygotes have rough eyes. Wings veins L2, L3, L4 and L5 occasionally have terminal gaps. Heterozygotes occasionally have a very slightly roughened eye, but are usually inseparable from wild-type.

Eyes small and rough; wing veins L2, L3, L4 and L5 do not always extend to margin. S1 +/+ ast1 has very small eyes with fused facets; veins L2 to L5 incomplete at tip. S1 ast1/+ ast1 has slightly larger eye than S1 +/+ ast1. S1 ast1/+ + resembles S1 +/+ +. S +/+ ast and ast/ast partially suppress px and net. Eyes of ast1/E(S)1 rough. Enhanced by: E(S). RK2.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

ast1 has visible | dominant phenotype, enhanceable by E(S)1

Enhancer of
Statement
Reference

ast1 is an enhancer of visible phenotype of rux3

ast1 is an enhancer of visible | dominant phenotype of S1

Other
Statement
Reference

S51, ast1 has visible phenotype

Phenotype Manifest In
Enhanced by
Statement
Reference

ast1 has eye phenotype, enhanceable by E(S)1

Enhancer of
Statement
Reference

ast[+]/ast1 is an enhancer of photoreceptor cell R7 phenotype of SosJC2, sev6

ast1 is an enhancer of eye phenotype of rux3

ast1 is an enhancer of eye phenotype of S1

ast1 is an enhancer of ommatidium phenotype of S1

Suppressor of
Statement
Reference

ast1/S1 is a suppressor of phenotype of pxunspecified

ast1 is a suppressor of phenotype of pxunspecified

ast1 is a suppressor of phenotype of netunspecified

ast1/S1 is a suppressor of phenotype of netunspecified

Other
Statement
Reference

S51, ast1 has eye phenotype

Additional Comments
Genetic Interactions
Statement
Reference

The suppression of the sev6 R7 phenotype by SosJC2 is almost entirely reversed if the flies are also made heterozygous for ast1 or ast4. In S1/ast1 transheterozygotes the eyes are reduced in size and many ommatidia are missing.

S51/ast1 flies have an extremely small and narrow eye, with a glasslike effect. The distal ends of wing veins L2 to L5 are missing to various degrees.

Dominantly enhances the S1 eye phenotype: double heterozygotes have extremely small, diamond-shaped eyes in which many of the facets are fused and the remainder are irregular in size and distribution. The phenotype is dominantly enhanced by E(S)1; ast1 E(S)1 double heterozygotes have rough eyes. Partially suppresses the phenotype or netunspecified or pxunspecified homozygotes. S1/ast1 tends to completely suppress the phenotype of netunspecified or pxunspecified homozygotes.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (12)
Notes on Origin
Discoverer

E. B. Lewis, Feb. 1938.

Arose in: S1.

Comments
Comments

Overlaps wild type rarely.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (12)