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Citation
Kotarski, M.A., Leonard, D.A., Bennett, S.A., Bishop, C.P., Wahn, S.D., Sedore, S.A., Shrader, M. (1998). The Drosophila gene asteroid encodes a novel protein and displays dosage-sensitive interactions with Star and Egfr.  Genome 41(2): 295--302.
FlyBase ID
FBrf0102955
Publication Type
Research paper
Abstract

The asteroid gene of Drosophila was found to lie within 189 bp of Star. Asteroid cDNA clones were isolated and sequenced and a single putative open reading frame was identified that encodes a novel protein of 815 amino acids with a calculated molecular mass of 93 kilodaltons. Using cDNA probes, asteroid transcripts were localized to the proliferative tissues of embryos and to the mitotically active tissue anterior to the morphogenetic furrow in eye imaginal discs. Ribonuclease protection assays identified a mutation of asteroid that acts as a dominant enhancer of Star mutations and also enhances the Ellipse mutation, EgfrE1. Based on these data, a model for asteroid gene function in EGF receptor signaling is presented.

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    Language of Publication
    English
    Additional Languages of Abstract
    French
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genome
    Title
    Genome
    Publication Year
    1987-
    ISBN/ISSN
    0831-2796
    Data From Reference
    Aberrations (4)
    Alleles (13)
    Genes (7)
    Insertions (1)