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Citation
Higson, T.S., Tessiatore, J.E., Bennett, S.A., Derk, R.C., Kotarski, M.A. (1993). The molecular organization of the Star/asteroid region, a region necessary for proper eye development in Drosophila melanogaster.  Genome 36(2): 356--366.
FlyBase ID
FBrf0058632
Publication Type
Research paper
Abstract

The Star/asteroid (S/ast) region of Drosophila melanogaster has been cloned by P element transposon tagging using the snw chromosome as a source of defective P elements. In each mutation examined, the element integrated into the region was a 0.5-kb element from a region proximal to sn and not one of the head-to-head elements from the sn locus. Previously described spontaneous and X-ray induced mutations of S and ast were located on the molecular map by Southern analysis and restriction endonuclease mapping of genomic clones. S mutations are either large deletions of the cloned region or DNA breaks located near the P element insertions that cause ast mutations. Both S and ast mutations reduce the steady-state amounts of a 3.4-kb RNA. The molecular data, together with the phenotypic interactions observed for S and ast alleles, are consistent with the interpretation that S and ast mutations are lesions within the same gene or within genes that are functionally related.

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    Language of Publication
    English
    Additional Languages of Abstract
    French
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genome
    Title
    Genome
    Publication Year
    1987-
    ISBN/ISSN
    0831-2796
    Data From Reference