FlyBase Allele Report: Dmel\pros[JO1]

General Information

Symbol

Dmel\pros^JO1

Species

D. melanogaster

Name

FlyBase ID

FBal0039821

Feature type

allele

Associated gene

Dmel\pros

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Kauffmann et al., 1996)

Mutagen

Delta2-3 transposase

(Vaessin et al., 1991)

P-element activity

(Kolodziej et al., 1995)

Progenitor genotype

pros^W

(Vaessin et al., 1991)

Cytology

Description

Deletion detectable on Southern blot extending into the presumptive pros coding region.

(Vaessin et al., 1991)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Kauffmann et al., 1996, Vaessin et al., 1991)

Phenotype Manifest In

axon

(Vaessin et al., 1991)

chordotonal organ & axon | lateral

(Kolodziej et al., 1995)

photoreceptor cell R7

(Cook et al., 2003)

presumptive embryonic/larval central nervous system

(Vaessin et al., 1991)

Detailed Description

Statement

Reference

Marker and axonal projection analysis of R7 cells in pros^JO1 and mutants indicates partial transformation of R7 photoreceptors cells towards and R8 photoreceptors cell fate.

(Cook et al., 2003)

Clones in the eye cause abnormal R7 morphology and alters the R7 retinotopic map.

(Kauffmann et al., 1996)

Mutant phenotype of lateral chordotonal axons includes: shorter axons or dorsally routed axons.

(Kolodziej et al., 1995)

No outgrowth of motorneuron axons along either the segmental or intersegmental nerve track occurs up to 1.5 hours after they would have exited the CNS in a wild type embryo. Axons from all four clusters of sensory neurons are misrouted. Total number of sensory neurons is normal. The specializations at the tips of the dendrites of neurons with single dendrites is normal in both number and location.

(Vaessin et al., 1991)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

pros^JO1 is an enhancer of phenotype of sina⁴

(Kauffmann et al., 1996)

pros[+]/pros^JO1 is an enhancer of ommatidium phenotype of pnt^T6/pnt^Δ88

(Kauffmann et al., 1996)

Suppressor of

Statement

Reference

pros^JO1 is a suppressor of phenotype of aop^yan-1

(Kauffmann et al., 1996)

Additional Comments

Genetic Interactions

Statement

Reference

pnt^Δ88/pnt^T6 phenotype (25% ommatidia are missing R7 cells) is dominantly enhanced by pros^JO1, leading to roughening of the external eye.

(Kauffmann et al., 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

pros^JO1

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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